Multiple endocrine neoplasia type 2 history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Symptoms of multiple endocrine neoplasia type 2 include headache, hoarseness of voice, palpitations, anxiety, and weight loss.

History and Symptoms

Constitutional Symptoms

• Tall, thin, "marfanoid" body build, in which long bones are disproportionately elongated
• Masses beneath mucosal surfaces in the mouth, lips, and eyes. Numerous yellowish-white, sessile, painless nodules on the lips or tongue, with deeper lesions having normal coloration. There may be enough neuromas in the body of the lips to produce enlargement and a "blubbery lip" appearance. Similar nodules may be seen on the sclera and eyelids
• Low muscle mass, sometimes with myopathy
• Weight loss
• Delayed puberty
• Sweating
• Hand tremor
• Sleeping difficulty
• Lethargy

Gastrointestinal Symptoms

• Trouble swallowing
• Diarrhea
• Abdominal pain
• Constipation
• Nausea
• Decreased appetite

Respiratory Symptoms

• Breathing problems
• Continuous cough
• Cough with blood

Cardiovascular Symptoms

• Chest pain
• Palpitations
• Anxiety often resembling that of a panic attack
• Diaphoresis

Neurologic Symptoms

• Headaches
• Irritability
• Nervousness
• Confusion

Ophthalmology Symptoms

• Dry eyes or lack of tears, which is an especially helpful sign in children

References

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