Multiple endocrine neoplasia type 2 classification: Difference between revisions
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{{Familytree| | | | | | | | | | B01 | | | | | | | | | | | | | | | | B02 | |B01= Multiple endocrine neoplasia type 2A|B02= Multiple endocrine neoplasia type 2B}} | {{Familytree| | | | | | | | | | B01 | | | | | | | | | | | | | | | | B02 | |B01= Multiple endocrine neoplasia type 2A|B02= Multiple endocrine neoplasia type 2B}} | ||
{{Familytree| | | | | |,|-|-|-|v|^|-|-|-|-|-|-|-|-|v|-|-|-|.| | | | |!| | | | | }} | {{Familytree| | | | | |,|-|-|-|v|^|-|-|-|-|-|-|-|-|v|-|-|-|.| | | | |!| | | | | }} | ||
{{Familytree| | | | | C01 | | C02 | | | | | | | | C03 | | C04 | | | C05 | | |C01= Multiple endocrine neoplasia type 2A classical|C02= Multiple endocrine neoplasia type 2A with cutaneous lichen amyloidosis|C03= Multiple endocrine neoplasia type 2A with [[Hirschsprung disease]]|C04= [[Familial medullary thyroid carcinoma]] without [[pheochromocytoma]] or [[parathyroid]] hyperplasia|C05= [[Medullary thyroid cancer]], [[pheochromocytoma]], [[marfanoid habitus]], and [[mucosal neuroma]]s or intestinal [[ganglioneuroma]]s}} | {{Familytree| | | | | C01 | | C02 | | | | | | | | C03 | | C04 | | | C05 | | |C01= Multiple endocrine neoplasia type 2A classical|C02= Multiple endocrine neoplasia type 2A with cutaneous lichen [[amyloidosis]]|C03= Multiple endocrine neoplasia type 2A with [[Hirschsprung disease]]|C04= [[Familial medullary thyroid carcinoma]] without [[pheochromocytoma]] or [[parathyroid]] hyperplasia|C05= [[Medullary thyroid cancer]], [[pheochromocytoma]], [[marfanoid habitus]], and [[mucosal neuroma]]s or intestinal [[ganglioneuroma]]s}} | ||
{{Familytree/end}} | {{Familytree/end}} | ||
Revision as of 15:42, 23 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Multiple endocrine neoplasia type 2 may be classified according to the types of tumor involved into 2 subtypes: multiple endocrine neoplasia type 2A and multiple endocrine neoplasia type 2B.
Classification
Multiple endocrine neoplasia type 2 (MEN2) can be further divided into three subtypes: type 2A, type 2B, and familial medullary thyroid carcinoma (FMTC).
- These subtypes differ in their characteristic signs and symptoms and risk of specific tumors, but are relatively consistent within any one family.
- Multiple endocrine neoplasia type 2A is characterized by the presence of medullary thyroid carcinoma, pheochromocytoma, and parathyroid hyperplasia or tumor.
- Multiple endocrine neoplasia type 2B is characterized by the presence of pheochromocytoma, mucocutaneous neuroma, and medullary thyroid cancer.[1]
- The following flowchart depicts the classification of multiple endocrine neoplasia type 2.[1]
Multiple endocrine neoplasia type 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Multiple endocrine neoplasia type 2A | Multiple endocrine neoplasia type 2B | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Multiple endocrine neoplasia type 2A classical | Multiple endocrine neoplasia type 2A with cutaneous lichen amyloidosis | Multiple endocrine neoplasia type 2A with Hirschsprung disease | Familial medullary thyroid carcinoma without pheochromocytoma or parathyroid hyperplasia | Medullary thyroid cancer, pheochromocytoma, marfanoid habitus, and mucosal neuromas or intestinal ganglioneuromas | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
References
- ↑ 1.0 1.1 Wells SA, Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF; et al. (2015). "Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma". Thyroid. 25 (6): 567–610. doi:10.1089/thy.2014.0335. PMC 4490627. PMID 25810047.