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{{Multiple endocrine neoplasia type 1}}
{{Multiple endocrine neoplasia type 1}}
{{CMG}}; {{AE}} {{Ammu}}
{{CMG}}; {{AE}} {{Ammu}}
==Overview==
==Overview==
Common physical examination findings of multiple endocrine neoplasia type 1 include [[rash]], [[lymphadenopathy]], [[fever]] and [[abdominal mass]].
==Physical Examination==
==Physical Examination==
===Appearance of the Patient===
===Appearance of the Patient===
* Appearance of the patients differ depending on the type of tumor and can be obese, thin or cachectic.
The general appearance of patients with multiple endocrine neoplasia type 1 range from normal appearance to [[obese]], thin, and [[Cachexia|cachectic]]. Patient appearance largely depends on the manifestations of the syndrome.<ref name="pmid20833329">{{cite journal |vauthors=Thakker RV |title=Multiple endocrine neoplasia type 1 (MEN1) |journal=Best Pract. Res. Clin. Endocrinol. Metab. |volume=24 |issue=3 |pages=355–70 |year=2010 |pmid=20833329 |doi=10.1016/j.beem.2010.07.003 |url=}}</ref><ref name="pmid23435440">{{cite journal |vauthors=Gaztambide S, Vazquez F, Castaño L |title=Diagnosis and treatment of multiple endocrine neoplasia type 1 (MEN1) |journal=Minerva Endocrinol. |volume=38 |issue=1 |pages=17–28 |year=2013 |pmid=23435440 |doi= |url=}}</ref><ref name="pmid10548885">{{cite journal |vauthors=Marx SJ, Agarwal SK, Kester MB, Heppner C, Kim YS, Skarulis MC, James LA, Goldsmith PK, Saggar SK, Park SY, Spiegel AM, Burns AL, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Emmert-Buck MR, Guru SC, Manickam P, Crabtree J, Erdos MR, Collins FS, Chandrasekharappa SC |title=Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias |journal=Recent Prog. Horm. Res. |volume=54 |issue= |pages=397–438; discussion 438–9 |year=1999 |pmid=10548885 |doi= |url=}}</ref>
 
===Vitals===
===Vitals===
====Temperature====
*A [[fever]] is often present
*A [[fever]] is often present
====Pulse====
=====Rate=====
*[[Tachycardia]] may be present
*[[Tachycardia]] may be present
=====Rhythm=====
*The [[pulse]] is regular
*The pulse is regular
====Respiratory Rate====
*[[Tachypnea]] may be present
*[[Tachypnea]] may be present
===Skin===
===Skin===
* Lesions may be present
* [[Skin]] eruption of red patches with irregular borders, intact and ruptured [[vesicles]], and crust formation
* Rash may be present
 
===Eyes===
===Eyes===
* [[Nystagmus]] may be present.
* [[Nystagmus]] may be present
* Extra-ocular movements may be abnormal
* Extra-ocular movements may be abnormal
===Ears===
===Ears===
* Hearing acuity may be reduced
*Auditory acuity may be reduced
*[[Weber test]] may be positive
 
*[[Rinne test]] may be positive
===Neck===
===Neck===
*[[Jugular venous pressure]] may be elevated
*[[Jugular venous pressure]] may be elevated
*[[Lymph nodes]] may be present.
* [[Lymphadenopathy]]
===Heart===
 
* Shortened QT interval.
===Abdomen===
===Abdomen===
*[[Abdominal tenderness]] may be present
* [[Abdominal tenderness]] may be present
*An [[acute abdomen]] may be present
* An abdominal [[mass]] may be present
*An abdominal mass may be present
 
===Extremities===
===Extremities===
*[[Clubbing]] may be present
*[[Cyanosis]] may be present
*[[Edema]] may be present
*[[Edema]] may be present
===Neurologic===
===Neurologic===
* Mental status may be altered
* Mental status may be altered
* Clonus may be present
* [[Clonus]] may be present
==Reference==
 
{{Reflist}}
==References==
{{reflist|2}}
 
[[Category:Oncology]]
[[Category:Endocrinology]]
 
{{WS}}
{{WH}}
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Endocrinology]]
[[Category:Surgery]]

Latest revision as of 02:45, 27 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Common physical examination findings of multiple endocrine neoplasia type 1 include rash, lymphadenopathy, fever and abdominal mass.

Physical Examination

Appearance of the Patient

The general appearance of patients with multiple endocrine neoplasia type 1 range from normal appearance to obese, thin, and cachectic. Patient appearance largely depends on the manifestations of the syndrome.[1][2][3]

Vitals

Skin

  • Skin eruption of red patches with irregular borders, intact and ruptured vesicles, and crust formation

Eyes

  • Nystagmus may be present
  • Extra-ocular movements may be abnormal

Ears

  • Auditory acuity may be reduced

Neck

Abdomen

Extremities

Neurologic

  • Mental status may be altered
  • Clonus may be present

References

  1. Thakker RV (2010). "Multiple endocrine neoplasia type 1 (MEN1)". Best Pract. Res. Clin. Endocrinol. Metab. 24 (3): 355–70. doi:10.1016/j.beem.2010.07.003. PMID 20833329.
  2. Gaztambide S, Vazquez F, Castaño L (2013). "Diagnosis and treatment of multiple endocrine neoplasia type 1 (MEN1)". Minerva Endocrinol. 38 (1): 17–28. PMID 23435440.
  3. Marx SJ, Agarwal SK, Kester MB, Heppner C, Kim YS, Skarulis MC, James LA, Goldsmith PK, Saggar SK, Park SY, Spiegel AM, Burns AL, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Emmert-Buck MR, Guru SC, Manickam P, Crabtree J, Erdos MR, Collins FS, Chandrasekharappa SC (1999). "Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias". Recent Prog. Horm. Res. 54: 397–438, discussion 438–9. PMID 10548885.

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