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:{{dablink|Miosis should not be confused with [[meiosis]], the cellular division process involved in sexual reproduction, or [[mitosis]], the cellular division of somatic body cells.}}
__NOTOC__
{{Infobox_Disease |
{{Infobox_Disease |
   Name          = {{PAGENAME}} |
   Name          = {{PAGENAME}} |
   Image          = Miosis.jpg |
   Image          = Miosis.jpg |
   Caption        = Miosis of the left eye |
   Caption        = Miosis of the left eye |
  DiseasesDB    = 8243 |
  ICD10          = {{ICD10|H|57|0|h55}} |
  ICD9          = {{ICD9|379.42}} |
  ICDO          = |
  OMIM          = |
  MedlinePlus    = |
  eMedicineSubj  = |
  eMedicineTopic = |
  MeshID        = D015877 |
}}
}}
{{SI}}
{{Miosis}}
'''For patient information, click [[Miosis (patient information)|here]]'''
 
{{CMG}}
{{CMG}}


{{SK}}: Pupillary constriction; constricted pupil; miotis
==[[Miosis overview|Overview]]==
==[[Miosis historical perspective|Historical Perspective]]==


==[[Miosis classification|Classifications]]==


==Overview==
==[[Miosis pathophysiology|Pathophysiology]]==
'''Miosis''' is a medical term for constriction of the [[pupil]]. It is the opposite of [[mydriasis]]. It is seen in a variety of medical conditions, and can also be caused by certain drugs and chemicals.  Eye drops used to intentionally cause miosis are known as "miotics". Extreme miosis is commonly called "pinpoint pupils", a situation that can be caused by use of opiates.


==Physiology of the photomotor reflex==
==[[Miosis causes|Causes]]==
Visual stimuli enters the eye,and through the retinal photoceptors is converted into an electric impulse, carried through the optic nerve ([[cranial nerve]] II) to the brain, where it connects to the pretectal nucleus of the high midbrain. It bypasses the lateral geniculate nucleus and the primary visual cortex. From the pretectal nucleus neurons send axons to neurons of the [[Edinger-Westphal nucleus]] whose visceromotor axons run along both the left and right oculomotor nerves. Visceromotor nerve axons (which constitute a portion of the III [[cranial nerve]], along with the somatomotor portion derived from the Edinger-Westphal nucleus) synapse on ciliary ganglion neurons, whose [[parasympathetic]] axons innervate the constrictor muscle of the iris, producing '''[[miosis]]'''.
[http://www.coldbacon.com/mdtruth/pics/netter/fn-oculomotor.jpg]
==Differential diagnosis of causes of miosis==
=== Age ===


The likelihood of suffering miosis increases with age.
==[[Miosis differential diagnosis|Differentiating Miosis from other Disorders]]==


=== Diseases ===
==[[Miosis epidemiology and demographics|Epidemiology and Demographics]]==
* [[Horner syndrome]] (a set of abnormalities in the nervous supply of the face due to damage to the [[sympathetic nervous system]]).
* [[Pancoast tumor]] (a [[lung cancer|tumor]] of the apical [[lung]]), due to damage to the ascending sympathetic tract that would normally cause the pupil to dilate.
* [[Hemorrhage]] into [[pons]] ([[intracranial hemorrhage]])


=== Drugs ===
==[[Miosis natural history, complications and prognosis|Natural History, Complications, and Prognosis]]==
* [[Opioid]]s such as [[tramadol]], [[codeine]], [[morphine]], [[heroin]] and [[methadone]]
* [[Antipsychotics]], including [[haloperidol]], [[thorazine]], [[olanzapine]], [[quetiapine]] and others
* [[Cholinergic]] agents such as those used to treat [[Alzheimer's disease]] and [[nerve gas]]es; cholinergic drugs such as [[carbachol]] (Miostat) and [[neostigmine]]
* Some cancer [[chemotherapy]] drugs, including [[camptothecin]] derivatives
* [[Mirtazapine]], a [[noradrenergic and specific serotonergic antidepressant]] ([[NaSSA]])
* [[Trazodone]]
* Some [[MAO_inhibitor|MAO Inhibitors]].
* In some rare cases, when exposed to [[mustard gas]].


===Miotics===
==Diagnosis==
A '''miotic''' substance causes the constriction of the [[pupil]] of the eye (or [[miosis]]). It is the opposite of a [[Mydriatic]] substance, which causes [[dilation]] of the pupil.
[[Miosis history and symptoms|History and Symptoms]] | [[Miosis physical examination|Physical Examination]] | [[Miosis laboratory findings|Laboratory Findings]] | [[Miosis chest x ray|X Rays]] | [[Miosis CT|CT]] | [[Miosis MRI|MRI]] | [[Miosis other imaging findings|Other Imaging Findings]] | [[Miosis other diagnostic studies|Other Diagnostic Studies]]
 
==Treatment==
[[Miosis medical therapy|Medical Therapy]] | [[Miosis surgery|Surgical]] | [[Miosis primary prevention|Primary Prevention]] | [[Miosis secondary prevention|Secondary Prevention]]
 
==Case Studies==
[[Miosis case study one|Case #1]]


==External links==
* [http://www.fpnotebook.com/EYE35.htm FP Notebook]
* {{GPnotebook|-1254817782}}


{{Antiglaucoma preparations and miotics}}
{{Antiglaucoma preparations and miotics}}
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[[bg:Миоза]]
[[de:Miosis]]
[[es:Miosis]]
[[es:Miosis]]
[[fr:Myosis]]
[[fr:Myosis]]
[[no:Miosis]]
[[pt:Miose]]
[[pt:Miose]]
[[ru:Миоз]]
[[ru:Миоз]]
[[sk:Mióza]]
[[sv:Mios]]
[[pl:Mioza]]
[[pl:Mioza]]




[[Category:Medical signs]]
[[Category:Signs and symptoms]]
[[Category:Physical examination]]
[[Category:Ophthalmology]]
[[Category:Ophthalmology]]
[[Category:Signs and symptoms]]
[[Category:Neurology]]
[[Category:Emergency medicine]]


{{WikiDoc Help Menu}}
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{{WikiDoc Sources}}
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Latest revision as of 15:39, 10 June 2015

Miosis
Miosis of the left eye

Miosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Miosis from other Diseases

Epidemiology and Demographics

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Case Studies

Case #1

Miosis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Miosis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Miosis

CDC on Miosis

Miosis in the news

Blogs on Miosis

Directions to Hospitals Treating Miosis

Risk calculators and risk factors for Miosis

For patient information, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords:: Pupillary constriction; constricted pupil; miotis

Overview

Historical Perspective

Classifications

Pathophysiology

Causes

Differentiating Miosis from other Disorders

Epidemiology and Demographics

Natural History, Complications, and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | X Rays | CT | MRI | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgical | Primary Prevention | Secondary Prevention

Case Studies

Case #1


Template:Antiglaucoma preparations and miotics


Template:WikiDoc Sources