Mebendazole
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alberto Plate [2]
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Overview
Mebendazole is a broad-spectrum anthelmintic that is FDA approved for the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections. Common adverse reactions include rash, abdominal pain, constipation, diarrhea and headache.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
The same dosage schedule applies to children and adults. The tablet may be chewed, swallowed, or crushed and mixed with food.
If the patient is not cured three weeks after treatment, a second course of treatment is advised. No special procedures, such as fasting or purging, are required.
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Mebendazole in adult patients.
Non–Guideline-Supported Use
Capilaria Infection
Cestodes Infections
- Dosage
Filariasis
- Dosage: 300 mg/day PO for 28-45 days[4]
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Mebendazole in pediatric patients.
Non–Guideline-Supported Use
Capilaria Infection
Contraindications
There is limited information regarding Mebendazole Contraindications in the drug label.
Warnings
There is limited information regarding Mebendazole Warnings' in the drug label.
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Mebendazole Clinical Trials Experience in the drug label.
Postmarketing Experience
There is limited information regarding Mebendazole Postmarketing Experience in the drug label.
Drug Interactions
There is limited information regarding Mebendazole Drug Interactions in the drug label.
Use in Specific Populations
Pregnancy
Pregnancy Category (FDA):
There is no FDA guidance on usage of Mebendazole in women who are pregnant.
Pregnancy Category (AUS):
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Mebendazole in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Mebendazole during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Mebendazole in women who are nursing.
Pediatric Use
There is no FDA guidance on the use of Mebendazole in pediatric settings.
Geriatic Use
There is no FDA guidance on the use of Mebendazole in geriatric settings.
Gender
There is no FDA guidance on the use of Mebendazole with respect to specific gender populations.
Race
There is no FDA guidance on the use of Mebendazole with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Mebendazole in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Mebendazole in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Mebendazole in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Mebendazole in patients who are immunocompromised.
Administration and Monitoring
Administration
There is limited information regarding Mebendazole Administration in the drug label.
Monitoring
There is limited information regarding Mebendazole Monitoring in the drug label.
IV Compatibility
There is limited information regarding the compatibility of Mebendazole and IV administrations.
Overdosage
There is limited information regarding Mebendazole overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.
Pharmacology
There is limited information regarding Mebendazole Pharmacology in the drug label.
Mechanism of Action
There is limited information regarding Mebendazole Mechanism of Action in the drug label.
Structure
There is limited information regarding Mebendazole Structure in the drug label.
Pharmacodynamics
There is limited information regarding Mebendazole Pharmacodynamics in the drug label.
Pharmacokinetics
There is limited information regarding Mebendazole Pharmacokinetics in the drug label.
Nonclinical Toxicology
There is limited information regarding Mebendazole Nonclinical Toxicology in the drug label.
Clinical Studies
There is limited information regarding Mebendazole Clinical Studies in the drug label.
How Supplied
There is limited information regarding Mebendazole How Supplied in the drug label.
Storage
There is limited information regarding Mebendazole Storage in the drug label.
Images
Drug Images
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Package and Label Display Panel
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Patient Counseling Information
There is limited information regarding Mebendazole Patient Counseling Information in the drug label.
Precautions with Alcohol
Alcohol-Mebendazole interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
There is limited information regarding Mebendazole Brand Names in the drug label.
Look-Alike Drug Names
There is limited information regarding Mebendazole Look-Alike Drug Names in the drug label.
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.
- ↑ 1.0 1.1 1.2 Keystone JS, Murdoch JK (1979). "Mebendazole". Ann Intern Med. 91 (4): 582–6. PMID 484964.
- ↑ 2.0 2.1 "Drugs for parasitic infections". Med Lett Drugs Ther. 34 (865): 17–26. 1992. PMID 1567506.
- ↑ Chavarria AP, Villarejos VM, Zeledón R (1977). "Mebendazole in the treatment of taeniasis solium and taeniasis saginata". Am J Trop Med Hyg. 26 (1): 118–20. PMID 842772.
- ↑ Van Hoegaerden M, Ivanoff B, Flocard F, Salle A, Chabaud B (1987). "The use of mebendazole in the treatment of filariases due to Loa loa and Mansonella perstans". Ann Trop Med Parasitol. 81 (3): 275–82. PMID 3478004.
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]
Overview
Mebendazole is a benzimidazole drug that is used to treat infestations by worms including pinworms,roundworms, tapeworms, hookworms, and whipworms. The active ingredient in Pripsen powder is piperazine.
Category
Anthelmintic
US Brand Names
MEBENDAZOLE®
FDA Package Insert
Description | Clinical Pharmacology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Dosage and Administration | How Supplied | Labels and Packages
Mechanism of Action
Mebendazole (C16H13N3O3) causes slow immobilization and death of the worms by selectively and irreversibly blocking uptake of glucose and other nutrients in susceptible adult intestine where helminths dwell. It is a spindle poison that induces chromosome nondisjunction.