Leprosy other diagnostic studies: Difference between revisions

Jump to navigation Jump to search
Line 12: Line 12:


===Skin Biopsy===
===Skin Biopsy===
A biopsy of the skin lesion should be performed and stained according to the ''Fite-Faraco'' technique (a especially designed protocol for staining the leprosy ''bacilli'').
A [[biopsy]] of the [[skin lesion]] should be performed and [[stained]] according to the ''Fite-Faraco'' technique (a especially designed protocol for [[staining]] the leprosy ''[[bacilli]]'').
According to the pole of leprosy in that patients, typical findings include:
According to the pole of leprosy in that patient, typical findings include:
* Tuberculoid pole -
* '''Tuberculoid pole''':
:* ''Bacilli'' are commonly not observed.
:* ''[[Bacilli]]'' are commonly not observed.
:* Granulomas commonly found.
:* [[Granulomas]] commonly found, containing:
:* Common nerve involvement.  
::* [[Epithelioid cells]].
* Lepromatous pole -
::* [[Lymphocytic infiltrate]].
::* [[Langerhans cells]].
:* Common [[nerve]] involvement.  
 
* Lepromatous pole:
:* [[Inflammatory infiltrate]].
:* [[Virchow cells]] loaded with ''[[bacilli]]''.
:* Loss of [[adnexal structures]].


===Lepromin Test===
===Lepromin Test===

Revision as of 15:57, 6 July 2014

Leprosy Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Leprosy from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Tertiary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Leprosy other diagnostic studies On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Leprosy other diagnostic studies

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Leprosy other diagnostic studies

CDC on Leprosy other diagnostic studies

Leprosy other diagnostic studies in the news

Blogs on Leprosy other diagnostic studies

Directions to Hospitals Treating Leprosy

Risk calculators and risk factors for Leprosy other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]

Overview

Although there are no laboratory studies to help in the diagnosis of leprosy, other studies such as biopsy of skin lesions and skin smear tests have an important contribution for the diagnosis of leprosy in patients in whom the diagnosis is suspected from the clinical presentation.

Other Diagnostic Studies

Smear test

May be obtained from any skin lesion, from the nasal mucosa and/or the ear lobe. This test has a sensitivity of 50% and a specificity of 100%. After collection of the [Laboratory specimen|specimen]], in order to visualize the bacteria, the Ziehl-Neelsen stain should be used.[1][2][3][4]

Skin Biopsy

A biopsy of the skin lesion should be performed and stained according to the Fite-Faraco technique (a especially designed protocol for staining the leprosy bacilli). According to the pole of leprosy in that patient, typical findings include:

  • Tuberculoid pole:
  • Common nerve involvement.
  • Lepromatous pole:

Lepromin Test

Serology

Polymerase Chain Reaction

References

  1. Eichelmann, K.; González González, S.E.; Salas-Alanis, J.C.; Ocampo-Candiani, J. (2013). "Leprosy. An Update: Definition, Pathogenesis, Classification, Diagnosis, and Treatment". Actas Dermo-Sifiliográficas (English Edition). 104 (7): 554–563. doi:10.1016/j.adengl.2012.03.028. ISSN 1578-2190.
  2. Hatta M, van Beers SM, Madjid B, Djumadi A, de Wit MY, Klatser PR (1995). "Distribution and persistence of Mycobacterium leprae nasal carriage among a population in which leprosy is endemic in Indonesia". Trans R Soc Trop Med Hyg. 89 (4): 381–5. PMID 7570870.
  3. Aggarwal A, Pandey A (2010). "Inverse sampling to study disease burden of leprosy". Indian J Med Res. 132: 438–41. PMID 20966523.
  4. Ramaprasad P, Fernando A, Madhale S, Rao JR, Edward VK, Samson PD; et al. (1997). "Transmission and protection in leprosy: indications of the role of mucosal immunity". Lepr Rev. 68 (4): 301–15. PMID 9503866.


Template:WikiDoc Sources