KLF5

Kruppel-like factor 5 (intestinal)
Identifiers
Symbols	KLF5 ; BTEB2; CKLF; IKLF
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37520
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE KLF5 209211 at tn.png
File:PBB GE KLF5 209212 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Kruppel-like factor 5 (intestinal), also known as KLF5, is a human gene.

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.

See also

• Kruppel-like factors

Further reading

• Ghaleb AM, Nandan MO, Chanchevalap S; et al. (2005). "Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation". Cell Res. 15 (2): 92–6. doi:10.1038/sj.cr.7290271. PMID 15740636.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagai R, Suzuki T, Aizawa K; et al. (2005). "Significance of the transcription factor KLF5 in cardiovascular remodeling". J. Thromb. Haemost. 3 (8): 1569–76. doi:10.1111/j.1538-7836.2005.01366.x. PMID 16102021.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McConnell BB, Ghaleb AM, Nandan MO, Yang VW (2007). "The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology". Bioessays. 29 (6): 549–57. doi:10.1002/bies.20581. PMID 17508399.CS1 maint: Multiple names: authors list (link)
• Sogawa K, Imataka H, Yamasaki Y; et al. (1993). "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2". Nucleic Acids Res. 21 (7): 1527–32. PMID 8479902.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kojima S, Kobayashi A, Gotoh O; et al. (1997). "Transcriptional activation domain of human BTEB2, a GC box-binding factor". J. Biochem. 121 (2): 389–96. PMID 9089417.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Conkright MD, Wani MA, Anderson KP, Lingrel JB (1999). "A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells". Nucleic Acids Res. 27 (5): 1263–70. PMID 9973612.CS1 maint: Multiple names: authors list (link)
• Shi H, Zhang Z, Wang X; et al. (2000). "Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter". Nucleic Acids Res. 27 (24): 4807–15. PMID 10572182.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoshino Y, Kurabayashi M, Kanda T; et al. (2000). "Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis". Circulation. 102 (20): 2528–34. PMID 11076828.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sun R, Chen X, Yang VW (2001). "Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation". J. Biol. Chem. 276 (10): 6897–900. doi:10.1074/jbc.C000870200. PMID 11152667.CS1 maint: Multiple names: authors list (link)
• Dang DT, Zhao W, Mahatan CS; et al. (2002). "Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene". Nucleic Acids Res. 30 (13): 2736–41. PMID 12087155.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shindo T, Manabe I, Fukushima Y; et al. (2002). "Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling". Nat. Med. 8 (8): 856–63. doi:10.1038/nm738. PMID 12101409.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sur I, Undén AB, Toftgård R (2003). "Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles". Eur. J. Cell Biol. 81 (6): 323–34. PMID 12113473.CS1 maint: Multiple names: authors list (link)
• Chen C, Bhalala HV, Qiao H, Dong JT (2002). "A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer". Oncogene. 21 (43): 6567–72. doi:10.1038/sj.onc.1205817. PMID 12242654.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang XO, Doty RT, Hicks JS, Willerford DM (2003). "Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs". Blood. 101 (11): 4492–9. doi:10.1182/blood-2002-08-2579. PMID 12576331.CS1 maint: Multiple names: authors list (link)
• Chen C, Bhalala HV, Vessella RL, Dong JT (2003). "KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer". Prostate. 55 (2): 81–8. doi:10.1002/pros.10205. PMID 12661032.CS1 maint: Multiple names: authors list (link)
• Zhang Z, Teng CT (2003). "Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function". Nucleic Acids Res. 31 (8): 2196–208. PMID 12682370.
• Ohnishi S, Ohnami S, Laub F; et al. (2003). "Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer". Biochem. Biophys. Res. Commun. 308 (2): 251–6. PMID 12901861.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aizawa K, Suzuki T, Kada N; et al. (2004). "Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB". J. Biol. Chem. 279 (1): 70–6. doi:10.1074/jbc.M306621200. PMID 14573617.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sato T, Kanda T, Iida T; et al. (2004). "Immunohistochemical study of surgically excised choroidal neovascular membranes". J. Int. Med. Res. 31 (5): 402–6. PMID 14587307.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• KLF5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.