Intracerebral metastases history and symptoms: Difference between revisions

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==Overview==
==Overview==
When evaluating a patient for intracerebral metastases, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough family and past medical history review. Other specific areas of focus when obtaining the history include review of the primary tumor (lung, brain, melanoma, colorectal cancer).<ref name=causesofintracerebralmetastasis>Causes of brain metastasis. Wikipedia 2015. https://en.wikipedia.org/wiki/Brain_metastasis. Accessed on November 9, 2015</ref><ref name=causesofintracerebralmetastasis2>Epidemiology of brain metastasis. Dr Bruno Di Muzio and Dr Trent Orton et al. Radiopaedia 2015. http://radiopaedia.org/articles/brain-metastases. Accessed on November 9, 2015</ref><ref name="RahmathullaToms2012">{{cite journal|last1=Rahmathulla|first1=Gazanfar|last2=Toms|first2=Steven A.|last3=Weil|first3=Robert J.|title=The Molecular Biology of Brain Metastasis|journal=Journal of Oncology|volume=2012|year=2012|pages=1–16|issn=1687-8450|doi=10.1155/2012/723541}}</ref> 60-75% of patients with intracerebral metastases may be asymptomatic.<ref name=symptomsofbrainmetastasis1>Clinical presentation of brain metastases. Dr Bruno Di Muzio and Dr Trent Orton et al. Radiopaedia 2015. http://radiopaedia.org/articles/brain-metastases. Accessed on November 9, 2015</ref> Symptoms of intracerebral metastases include [[headache]], [[seizures]], [[visual loss|visual disturbances]], [[cognition|cognitive dysfunction]], [[paresthesia]], and [[muscle weakness]].<ref name=symptomsofbrainmetastasis1>Clinical presentation of brain metastases. Dr Bruno Di Muzio and Dr Trent Orton et al. Radiopaedia 2015. http://radiopaedia.org/articles/brain-metastases. Accessed on November 9, 2015</ref><ref name=symptomsofbrainmetastases2>Symptoms of brain metastases. Wikipedia 2015. https://en.wikipedia.org/wiki/Brain_metastasis. Accessed on November 9, 2015</ref><ref name=symptomsofbrainmetastases3>Symptoms of metastatic brain tumor. US national library of medicine 2015. https://www.nlm.nih.gov/medlineplus/ency/article/000769.htm. Accessed on November 9, 2015</ref><ref name=historicalperspectiveofintracerebralmetastases>{{Cite journal
| author = [[Andrew B. Lassman]] & [[Lisa M. DeAngelis]] | title = Brain metastases | journal = [[Neurologic clinics]] | volume = 21 | issue = 1 | pages = 1–23 | year = 2003 | month = February | pmid = 12690643}}</ref>


==History==
==History==
When evaluating a patient for intracerebral metastases, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough family and past medical history review. Other specific areas of focus when obtaining the history include:<ref name=causesofintracerebralmetastasis>Causes of brain metastasis. Wikipedia 2015. https://en.wikipedia.org/wiki/Brain_metastasis. Accessed on November 9, 2015</ref><ref name=causesofintracerebralmetastasis2>Epidemiology of brain metastasis. Dr Bruno Di Muzio and Dr Trent Orton et al. Radiopaedia 2015. http://radiopaedia.org/articles/brain-metastases. Accessed on November 9, 2015</ref><ref name="RahmathullaToms2012">{{cite journal|last1=Rahmathulla|first1=Gazanfar|last2=Toms|first2=Steven A.|last3=Weil|first3=Robert J.|title=The Molecular Biology of Brain Metastasis|journal=Journal of Oncology|volume=2012|year=2012|pages=1–16|issn=1687-8450|doi=10.1155/2012/723541}}</ref>
*Review of the primary tumor (lung, brain, melanoma, colorectal cancer)


==Symptoms==
==Symptoms==
*60-75% of patients with intracerebral metastases may be asymptomatic.<ref name=symptomsofbrainmetastasis>Clinical presentation of brain metastases. Dr Bruno Di Muzio and Dr Trent Orton et al. Radiopaedia 2015. http://radiopaedia.org/articles/brain-metastases. Accessed on November 9, 2015</ref>
*60-75% of patients with intracerebral metastases may be asymptomatic.<ref name=symptomsofbrainmetastasis1>Clinical presentation of brain metastases. Dr Bruno Di Muzio and Dr Trent Orton et al. Radiopaedia 2015. http://radiopaedia.org/articles/brain-metastases. Accessed on November 9, 2015</ref>
*Symptoms of intracerebral metastases include:
*Symptoms of intracerebral metastases include:<ref name=symptomsofbrainmetastasis1>Clinical presentation of brain metastases. Dr Bruno Di Muzio and Dr Trent Orton et al. Radiopaedia 2015. http://radiopaedia.org/articles/brain-metastases. Accessed on November 9, 2015</ref><ref name=symptomsofbrainmetastases2>Symptoms of brain metastases. Wikipedia 2015. https://en.wikipedia.org/wiki/Brain_metastasis. Accessed on November 9, 2015</ref><ref name=symptomsofbrainmetastases3>Symptoms of metastatic brain tumor. US national library of medicine 2015. https://www.nlm.nih.gov/medlineplus/ency/article/000769.htm. Accessed on November 9, 2015</ref><ref name=historicalperspectiveofintracerebralmetastases>{{Cite journal
| author = [[Andrew B. Lassman]] & [[Lisa M. DeAngelis]] | title = Brain metastases | journal = [[Neurologic clinics]] | volume = 21 | issue = 1 | pages = 1–23 | year = 2003 | month = February | pmid = 12690643}}</ref>
:*[[headache|New-onset headache]]
:*[[headache|New-onset headache]]
:*[[Seizure]]
:*[[Seizure]]
:*[[Fever]]
:*[[Lethargy]]
:*[[Dizziness]]
:*[[Speech difficulties]]
:*[[Nausea]]
:*[[Nausea]]
:*[[Vomiting]]
:*[[Vomiting]]
:*[[visual loss|Visual disturbances]].
:*[[Back pain]]
 
:*[[Ataxia|Loss of balance]]
Patients with brain mets have a mean survival of one month without treatment.  With treatment, survival improves, but it is still dismal.  The mean age of survival is still less than one year.
:*[[visual loss|Visual disturbances]]
 
:*[[Vertigo]]
==Physical Examination==
:*[[mood|Mood changes]]
mental status changes, ataxia,
:*[[Personality pathology|Changes in personality]]
:*[[Memory loss]]
:*[[cognition|Cognitive dysfunction]]
:*[[behavioral|Changes in behavior]]
:*[[Paresthesia]]
:*[[Muscle weakness]]


==References==
==References==

Latest revision as of 20:43, 23 November 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

When evaluating a patient for intracerebral metastases, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough family and past medical history review. Other specific areas of focus when obtaining the history include review of the primary tumor (lung, brain, melanoma, colorectal cancer).[1][2][3] 60-75% of patients with intracerebral metastases may be asymptomatic.[4] Symptoms of intracerebral metastases include headache, seizures, visual disturbances, cognitive dysfunction, paresthesia, and muscle weakness.[4][5][6][7]

History

When evaluating a patient for intracerebral metastases, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough family and past medical history review. Other specific areas of focus when obtaining the history include:[1][2][3]

  • Review of the primary tumor (lung, brain, melanoma, colorectal cancer)

Symptoms

  • 60-75% of patients with intracerebral metastases may be asymptomatic.[4]
  • Symptoms of intracerebral metastases include:[4][5][6][7]

References

  1. ↑ 1.0 1.1 Causes of brain metastasis. Wikipedia 2015. https://en.wikipedia.org/wiki/Brain_metastasis. Accessed on November 9, 2015
  2. ↑ 2.0 2.1 Epidemiology of brain metastasis. Dr Bruno Di Muzio and Dr Trent Orton et al. Radiopaedia 2015. http://radiopaedia.org/articles/brain-metastases. Accessed on November 9, 2015
  3. ↑ 3.0 3.1 Rahmathulla, Gazanfar; Toms, Steven A.; Weil, Robert J. (2012). "The Molecular Biology of Brain Metastasis". Journal of Oncology. 2012: 1–16. doi:10.1155/2012/723541. ISSN 1687-8450.
  4. ↑ 4.0 4.1 4.2 4.3 Clinical presentation of brain metastases. Dr Bruno Di Muzio and Dr Trent Orton et al. Radiopaedia 2015. http://radiopaedia.org/articles/brain-metastases. Accessed on November 9, 2015
  5. ↑ 5.0 5.1 Symptoms of brain metastases. Wikipedia 2015. https://en.wikipedia.org/wiki/Brain_metastasis. Accessed on November 9, 2015
  6. ↑ 6.0 6.1 Symptoms of metastatic brain tumor. US national library of medicine 2015. https://www.nlm.nih.gov/medlineplus/ency/article/000769.htm. Accessed on November 9, 2015
  7. ↑ 7.0 7.1 Andrew B. Lassman & Lisa M. DeAngelis (2003). "Brain metastases". Neurologic clinics. 21 (1): 1–23. PMID 12690643. Unknown parameter |month= ignored (help)


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