High chylomicron causes: Difference between revisions

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Latest revision as of 20:48, 5 February 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Twinkle Singh, M.B.B.S. [2]

Overview

Hyperchylomicronemia occurs more commonly as a result of decreased lipoprotein lipase enzyme activity. The causes of hyperchylomicronemia could either be genetic as in type I and type V hyperlipoproteinemia or secondary to conditions such as alcoholism, chronic renal failure, hypothyroidism, and diabetes mellitus. Secondary causes are more frequent than primary genetic etiologies.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Hyperchylomicronemia does not have life-threatening causes.

Common Causes

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Heparin, oral contraceptives, thiazide diuretics
Ear Nose Throat	No underlying causes
Endocrine	Diabetes mellitus, hypothyroidism
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	Glycogen storage disease type I, lipoprotein lipase deficiency, type 1C hyperlipoproteinemia, mixed hyperlipoproteinemia
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	Familial hypertriglyceridemia, glycogen storage disease type I, lipoprotein lipase deficiency
Obstetric/Gynecologic	Pregnancy
Oncologic	No underlying causes
Ophthalmologic	No underlying causes
Overdose/Toxicity	Alcohol
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	Chronic renal failure
Rheumatology/Immunology/Allergy	Autoimmune hyperchylomicronemia ^[1]
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes by Alphabetical Order

References

↑ ^1.0 ^1.1 Yoshimura, T.; Ito, M.; Sakoda, Y.; Kobori, S.; Okamura, H. (1998). "Rare case of autoimmune hyperchylomicronemia during pregnancy". Eur J Obstet Gynecol Reprod Biol. 76 (1): 49–51. PMID 9481547. Unknown parameter |month= ignored (help)

Template:WikiDoc Sources

[Yoshimura-1998-1] 1.0 ^1.1 Yoshimura, T.; Ito, M.; Sakoda, Y.; Kobori, S.; Okamura, H. (1998). "Rare case of autoimmune hyperchylomicronemia during pregnancy". Eur J Obstet Gynecol Reprod Biol. 76 (1): 49–51. PMID 9481547. Unknown parameter |month= ignored (help)

[1]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Chylomicron}}
-{{CMG}}
+{{CMG}} {{AE}} {{TS}}
 ==Overview==
+Hyperchylomicronemia occurs more commonly as a result of decreased [[lipoprotein lipase]] enzyme activity.  The causes of hyperchylomicronemia could either be [[genetic]] as in [[Hyperlipoproteinemia|type I and type V hyperlipoproteinemia]] or secondary to conditions such as [[alcoholism]], [[chronic renal failure]], [[hypothyroidism]], and [[diabetes mellitus]].  Secondary causes are more frequent than primary genetic etiologies.
 ==Causes==
 ===Life Threatening Causes===
+Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
+Hyperchylomicronemia does not have life-threatening causes.
 ===Common Causes===
+*[[Alcoholism]]
+*[[Chronic renal failure]]
+*[[Diabetes mellitus]]
+*[[Hypothyroidism]]
+*[[Combined oral contraceptive pill|Oral contraceptives]]
+*[[Pregnancy]]
+*[[Thiazide|Thiazide diuretics]]
 ===Causes by Organ System===
@@ Line 29: / Line 40: @@
 |-bgcolor="LightSteelBlue"
 | '''Drug Side Effect'''
-|bgcolor="Beige"| [[Thiazide ]]
+|bgcolor="Beige"| [[Heparin]], [[Combined oral contraceptive pill|oral contraceptives]], [[Thiazide|thiazide diuretics]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 37: / Line 48: @@
 |-bgcolor="LightSteelBlue"
 | '''Endocrine'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Diabetes mellitus]], [[hypothyroidism]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 49: / Line 60: @@
 |-bgcolor="LightSteelBlue"
 | '''Genetic'''
-|bgcolor="Beige"| [[Glycogen storage disease type 1 ]], [[lipoprotein lipase deficiency ]], [[type 1C hyperlipoproteinemia]], [[type V hyperlipoprotenemia ]]
+|bgcolor="Beige"| [[Glycogen storage disease type I]], [[lipoprotein lipase deficiency]], [[familial hyperchylomicronemia|type 1C hyperlipoproteinemia]], [[mixed hyperlipoproteinemia ]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 73: / Line 84: @@
 |-bgcolor="LightSteelBlue"
 | '''Nutritional/Metabolic'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Familial hypertriglyceridemia]], [[glycogen storage disease type I]], [[lipoprotein lipase deficiency]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Obstetric/Gynecologic'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Pregnancy]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 89: / Line 100: @@
 |-bgcolor="LightSteelBlue"
 | '''Overdose/Toxicity'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Alcoholism|Alcohol]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 101: / Line 112: @@
 |-bgcolor="LightSteelBlue"
 | '''Renal/Electrolyte'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Chronic renal failure]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Rheumatology/Immunology/Allergy'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Autoimmune hyperchylomicronemia ]]<ref name="Yoshimura-1998">{{Cite journal  | last1 = Yoshimura | first1 = T. | last2 = Ito | first2 = M. | last3 = Sakoda | first3 = Y. | last4 = Kobori | first4 = S. | last5 = Okamura | first5 = H. | title = Rare case of autoimmune hyperchylomicronemia during pregnancy. | journal = Eur J Obstet Gynecol Reprod Biol | volume = 76 | issue = 1 | pages = 49-51 | month = Jan | year = 1998 | doi =  | PMID = 9481547 }}</ref>
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 128: / Line 139: @@
 {{col-begin|width=80%}}
 {{col-break|width=33%}}
-*[[Alcohol]]
+*[[Alcoholism]]
-*[[Autoimmune hyperchylomicronemia]]
+*Autoimmune hyperchylomicronemia<ref name="Yoshimura-1998">{{Cite journal  | last1 = Yoshimura | first1 = T. | last2 = Ito | first2 = M. | last3 = Sakoda | first3 = Y. | last4 = Kobori | first4 = S. | last5 = Okamura | first5 = H. | title = Rare case of autoimmune hyperchylomicronemia during pregnancy. | journal = Eur J Obstet Gynecol Reprod Biol | volume = 76 | issue = 1 | pages = 49-51 | month = Jan | year = 1998 | doi =  | PMID = 9481547 }}</ref>
 *[[Chronic renal failure]]
 *[[Diabetes mellitus]]
-*[[Familial hyperchylomicronemia|Familial apolipoprotein C-II deficiency, type 1b]]
+*[[Familial hyperchylomicronemia|Type 1B hyperlipoproteinemia]]
 *[[Familial hypertriglyceridemia]]
 *[[Glycogen storage disease type I]]
-*[[Heparin ]]
+*[[Heparin]]
+*[[Hypothyroidism]]
 *[[Familial hyperchylomicronemia|Lipoprotein lipase deficiency]]
-*[[Oral contraceptive]]
+*[[Combined oral contraceptive pill|Oral contraceptives]]
-*[[Pregnancy ]]
+*[[Pregnancy]]
-*[[Thiazide ]]
+*[[Thiazide|Thiazide diuretics]]
 *[[Familial hyperchylomicronemia|Type 1C hyperlipoproteinemia]]
 *[[Mixed hyperlipoproteinemia ]]
 {{col-end}}

v t e Lipopedia
Basic Science	Cholesterol • Triglyceride Lipoprotein metabolism and transport Lipoprotein: Chylomicron • Chylomicron remnant • HDL • IDL • LDL • Lipoprotein(a) • VLDL • Lipoprotein-X Apolipoprotein: APOA (1, 2, 4, 5) • APOB ( Apolipoprotein B-48, Apolipoprotein B-100) • APOC (1, 2, 3, 4) • APOD • APOE • APOH • APOJ • APOL • APOM • Apo(a) Lipoprotein receptor: LDL receptor • Soluble low density lipoprotein receptor-related protein (sLRP) • Apolipoprotein E Receptor 2 • Scavenger receptor • Scavenger receptor A • Scavenger receptor B • VLDL receptor Lipoprotein enzymes: Lipoprotein lipase • Lipoprotein-associated phospholipase A2 (Lp-PLA2) • Cholesterylester transfer protein ( Acetyl-CoA C-acyltransferase, Lecithin-cholesterol acyltransferase) • Microsomal triglyceride transfer protein • ABCA1 Genes: Low density lipoprotein receptor gene family • Microsomal triglyceride transfer protein • ABCA1
Lipoprotein Disorders	Lipoprotein disorders Primary lipoprotein disorders: Familial hyperchylomicronemia (Type I) • Familial hypercholesterolemia (Type IIA) • Familial combined hyperlipidemia (Type IIB) • Dysbetalipoproteinemia (Type III) • Primary hypertriglyceridemia (Type IV) • Mixed hyperlipoproteinemia (Type V) Secondary lipoprotein disorders
Abnormal Laboratory Lipid Profile	Low chylomicron • Low chylomicron remnant • Low HDL • Low IDL • Low LDL • Low lipoprotein(a) • Low VLDL High chylomicron • High chylomicron remnant • High HDL • High IDL • High LDL • High Lipoprotein(a) • High VLDL