HOXD9

Homeobox D9
File:PBB Protein HOXD9 image.jpg PDB rendering based on 1puf.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1puf​
Identifiers
Symbols	HOXD9 ; HOX4; HOX4C; Hox-4.3; Hox-5.2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8409
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Homeobox D9, also known as HOXD9, is a human gene.

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined.

See also

• Homeobox

Further reading

• Scott MP (1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. PMID 1358459.
• Zappavigna V, Renucci A, Izpisúa-Belmonte JC; et al. (1992). "HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities". EMBO J. 10 (13): 4177–87. PMID 1756725.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. PMID 1973146.
• Oliver G, Sidell N, Fiske W; et al. (1989). "Complementary homeo protein gradients in developing limb buds". Genes Dev. 3 (5): 641–50. PMID 2568311.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Acampora D, D'Esposito M, Faiella A; et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. PMID 2574852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kanzler B, Viallet JP, Le Mouellic H; et al. (1995). "Differential expression of two different homeobox gene families during mouse tegument morphogenesis". Int. J. Dev. Biol. 38 (4): 633–40. PMID 7779685.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zappavigna V, Sartori D, Mavilio F (1994). "Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeo domain". Genes Dev. 8 (6): 732–44. PMID 7926763.CS1 maint: Multiple names: authors list (link)
• Zappavigna V, Falciola L, Helmer-Citterich M; et al. (1996). "HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation". EMBO J. 15 (18): 4981–91. PMID 8890171.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Phelan ML, Featherstone MS (1997). "Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers". J. Biol. Chem. 272 (13): 8635–43. PMID 9079695.
• Del Campo M, Jones MC, Veraksa AN; et al. (1999). "Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster". Am. J. Hum. Genet. 65 (1): 104–10. PMID 10364522.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de la Cruz CC, Der-Avakian A, Spyropoulos DD; et al. (2000). "Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development". Dev. Biol. 216 (2): 595–610. doi:10.1006/dbio.1999.9528. PMID 10642795.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Limongi MZ, Pelliccia F, Gaddini L, Rocchi A (2000). "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1". Cytogenet. Cell Genet. 90 (1–2): 151–3. PMID 11060466.CS1 maint: Multiple names: authors list (link)
• Goodman FR, Majewski F, Collins AL, Scambler PJ (2002). "A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly". Am. J. Hum. Genet. 70 (2): 547–55. PMID 11778160.CS1 maint: Multiple names: authors list (link)
• Kosaki K, Kosaki R, Suzuki T; et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nguyen NC, Hirose T, Nakazawa M; et al. (2002). "Expression of HOXD9 in fibroblast-like synoviocytes from rheumatoid arthritis patients". Int. J. Mol. Med. 10 (1): 41–8. PMID 12060849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Méchine-Neuville A, Lefebvre O, Bellocq JP; et al. (2003). "[Increased expression of HOXA9 gene in Hirschsprung disease]". Gastroenterol. Clin. Biol. 26 (12): 1110–7. PMID 12520199.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu DB, Gu ZD, Cao XZ; et al. (2005). "Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas". World J. Gastroenterol. 11 (10): 1562–6. PMID 15770739.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhao X, Sun M, Zhao J; et al. (2007). "Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome". Am. J. Hum. Genet. 80 (2): 361–71. doi:10.1086/511387. PMID 17236141.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• HOXD9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.