HEY1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (1 revision imported)
 
(2 intermediate revisions by 2 users not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Hairy/enhancer-of-split related with YRPW motif protein 1''' is a [[protein]] that in humans is encoded by the ''HEY1'' [[gene]].<ref name="pmid10415358">{{cite journal | vauthors = Leimeister C, Externbrink A, Klamt B, Gessler M | title = Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis | journal = Mechanisms of Development | volume = 85 | issue = 1-2 | pages = 173–7 | date = Jul 1999 | pmid = 10415358 | pmc =  | doi = 10.1016/S0925-4773(99)00080-5 }}</ref><ref name="pmid10403790">{{cite journal | vauthors = Kokubo H, Lun Y, Johnson RL | title = Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split | journal = Biochemical and Biophysical Research Communications | volume = 260 | issue = 2 | pages = 459–65 | date = Jul 1999 | pmid = 10403790 | pmc = | doi = 10.1006/bbrc.1999.0880 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23462| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_HEY1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2db7.
| PDB = {{PDB2|2db7}}
| Name = Hairy/enhancer-of-split related with YRPW motif 1
| HGNCid = 4880
| Symbol = HEY1
| AltSymbols =; CHF2; HERP2; HESR1; HRT-1; MGC1274; OAF1
| OMIM = 602953
| ECnumber = 
| Homologene = 7756
| MGIid = 1341800
| GeneAtlas_image1 = PBB_GE_HEY1_44783_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HEY1_218839_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23462
    | Hs_Ensembl = ENSG00000164683
    | Hs_RefseqProtein = NP_001035798
    | Hs_RefseqmRNA = NM_001040708
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 80838801
    | Hs_GenLoc_end = 80842560
    | Hs_Uniprot = Q9Y5J3
    | Mm_EntrezGene = 15213
    | Mm_Ensembl = ENSMUSG00000040289
    | Mm_RefseqmRNA = NM_010423
    | Mm_RefseqProtein = NP_034553
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 8646435
    | Mm_GenLoc_end = 8650112
    | Mm_Uniprot = Q9D0R0
  }}
}}
'''Hairy/enhancer-of-split related with YRPW motif 1''', also known as '''HEY1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23462| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a [[nuclear protein]] belonging to the hairy and enhancer of split-related (HESR) family of [[basic helix-loop-helix]] (bHLH)-type [[Transcription (biology)|transcriptional]] repressors. [[Gene expression|Expression]] of this gene is induced by the [[Notch signaling pathway|Notch]] and [[C-jun|c-Jun]] signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic [[Circulatory system|cardiovascular]] development, and are also implicated in [[neurogenesis]] and [[somitogenesis]]. Alternative splicing results in multiple [[transcript variants]].<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23462| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Iso T, Kedes L, Hamamori Y | title = HES and HERP families: multiple effectors of the Notch signaling pathway | journal = Journal of Cellular Physiology | volume = 194 | issue = 3 | pages = 237–55 | date = Mar 2003 | pmid = 12548545 | doi = 10.1002/jcp.10208 }}
| citations =
* {{cite journal | vauthors = Kokubo H, Miyagawa-Tomita S, Johnson RL | title = Hesr, a mediator of the Notch signaling, functions in heart and vessel development | journal = Trends in Cardiovascular Medicine | volume = 15 | issue = 5 | pages = 190–4 | date = Jul 2005 | pmid = 16165016 | doi = 10.1016/j.tcm.2005.05.005 }}
*{{cite journal | author=Iso T, Kedes L, Hamamori Y |title=HES and HERP families: multiple effectors of the Notch signaling pathway. |journal=J. Cell. Physiol. |volume=194 |issue= 3 |pages= 237-55 |year= 2003 |pmid= 12548545 |doi= 10.1002/jcp.10208 }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Kokubo H, Miyagawa-Tomita S, Johnson RL |title=Hesr, a mediator of the Notch signaling, functions in heart and vessel development. |journal=Trends Cardiovasc. Med. |volume=15 |issue= 5 |pages= 190-4 |year= 2006 |pmid= 16165016 |doi= 10.1016/j.tcm.2005.05.005 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Chin MT, Maemura K, Fukumoto S, Jain MK, Layne MD, Watanabe M, Hsieh CM, Lee ME | title = Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system | journal = The Journal of Biological Chemistry | volume = 275 | issue = 9 | pages = 6381–7 | date = Mar 2000 | pmid = 10692439 | doi = 10.1074/jbc.275.9.6381 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
* {{cite journal | vauthors = Steidl C, Leimeister C, Klamt B, Maier M, Nanda I, Dixon M, Clarke R, Schmid M, Gessler M | title = Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family | journal = Genomics | volume = 66 | issue = 2 | pages = 195–203 | date = Jun 2000 | pmid = 10860664 | doi = 10.1006/geno.2000.6200 }}
*{{cite journal  | author=Kokubo H, Lun Y, Johnson RL |title=Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split. |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 2 |pages= 459-65 |year= 1999 |pmid= 10403790 |doi= 10.1006/bbrc.1999.0880 }}
* {{cite journal | vauthors = Maier MM, Gessler M | title = Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes | journal = Biochemical and Biophysical Research Communications | volume = 275 | issue = 2 | pages = 652–60 | date = Aug 2000 | pmid = 10964718 | doi = 10.1006/bbrc.2000.3354 }}
*{{cite journal  | author=Leimeister C, Externbrink A, Klamt B, Gessler M |title=Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. |journal=Mech. Dev. |volume=85 |issue= 1-2 |pages= 173-7 |year= 1999 |pmid= 10415358 |doi=  }}
* {{cite journal | vauthors = Nakagawa O, McFadden DG, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, Olson EN | title = Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 25 | pages = 13655–60 | date = Dec 2000 | pmid = 11095750 | pmc = 17631 | doi = 10.1073/pnas.250485597 }}
*{{cite journal | author=Chin MT, Maemura K, Fukumoto S, ''et al.'' |title=Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6381-7 |year= 2000 |pmid= 10692439 |doi= }}
* {{cite journal | vauthors = Sun J, Kamei CN, Layne MD, Jain MK, Liao JK, Lee ME, Chin MT | title = Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 21 | pages = 18591–6 | date = May 2001 | pmid = 11279181 | doi = 10.1074/jbc.M101163200 }}
*{{cite journal | author=Steidl C, Leimeister C, Klamt B, ''et al.'' |title=Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. |journal=Genomics |volume=66 |issue= 2 |pages= 195-203 |year= 2000 |pmid= 10860664 |doi= 10.1006/geno.2000.6200 }}
* {{cite journal | vauthors = Iso T, Sartorelli V, Chung G, Shichinohe T, Kedes L, Hamamori Y | title = HERP, a new primary target of Notch regulated by ligand binding | journal = Molecular and Cellular Biology | volume = 21 | issue = 17 | pages = 6071–9 | date = Sep 2001 | pmid = 11486044 | pmc = 87324 | doi = 10.1128/MCB.21.17.6071-6079.2001 }}
*{{cite journal | author=Maier MM, Gessler M |title=Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes. |journal=Biochem. Biophys. Res. Commun. |volume=275 |issue= 2 |pages= 652-60 |year= 2000 |pmid= 10964718 |doi= 10.1006/bbrc.2000.3354 }}
* {{cite journal | vauthors = Taylor KL, Henderson AM, Hughes CC | title = Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression | journal = Microvascular Research | volume = 64 | issue = 3 | pages = 372–83 | date = Nov 2002 | pmid = 12453432 | doi = 10.1006/mvre.2002.2443 }}
*{{cite journal | author=Nakagawa O, McFadden DG, Nakagawa M, ''et al.'' |title=Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 25 |pages= 13655-60 |year= 2001 |pmid= 11095750 |doi= 10.1073/pnas.250485597 }}
* {{cite journal | vauthors = Elagib KE, Xiao M, Hussaini IM, Delehanty LL, Palmer LA, Racke FK, Birrer MJ, Ganapathy-Kanniappan S, Shanmugasundaram G, McDevitt MA, Goldfarb AN | title = Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2 | journal = Molecular and Cellular Biology | volume = 24 | issue = 17 | pages = 7779–94 | date = Sep 2004 | pmid = 15314183 | pmc = 506977 | doi = 10.1128/MCB.24.17.7779-7794.2004 }}
*{{cite journal | author=Sun J, Kamei CN, Layne MD, ''et al.'' |title=Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 18591-6 |year= 2001 |pmid= 11279181 |doi= 10.1074/jbc.M101163200 }}
* {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Research | volume = 14 | issue = 9 | pages = 1711–8 | date = Sep 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
*{{cite journal | author=Iso T, Sartorelli V, Chung G, ''et al.'' |title=HERP, a new primary target of Notch regulated by ligand binding. |journal=Mol. Cell. Biol. |volume=21 |issue= 17 |pages= 6071-9 |year= 2001 |pmid= 11486044 |doi= }}
* {{cite journal | vauthors = Kokubo H, Miyagawa-Tomita S, Nakazawa M, Saga Y, Johnson RL | title = Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system | journal = Developmental Biology | volume = 278 | issue = 2 | pages = 301–9 | date = Feb 2005 | pmid = 15680351 | doi = 10.1016/j.ydbio.2004.10.025 }}
*{{cite journal | author=Taylor KL, Henderson AM, Hughes CC |title=Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression. |journal=Microvasc. Res. |volume=64 |issue= 3 |pages= 372-83 |year= 2003 |pmid= 12453432 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Elagib KE, Xiao M, Hussaini IM, ''et al.'' |title=Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2. |journal=Mol. Cell. Biol. |volume=24 |issue= 17 |pages= 7779-94 |year= 2004 |pmid= 15314183 |doi= 10.1128/MCB.24.17.7779-7794.2004 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Kokubo H, Miyagawa-Tomita S, Nakazawa M, ''et al.'' |title=Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system. |journal=Dev. Biol. |volume=278 |issue= 2 |pages= 301-9 |year= 2005 |pmid= 15680351 |doi= 10.1016/j.ydbio.2004.10.025 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|HEY1+protein,+human}}
* {{MeshName|HEY1+protein,+human}}
* {{FactorBook|HEY1}}


{{NLM content}}
{{PDB Gallery|geneid=23462}}
{{Transcription factors|g1}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-8-stub}}

Latest revision as of 08:42, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Hairy/enhancer-of-split related with YRPW motif protein 1 is a protein that in humans is encoded by the HEY1 gene.[1][2][3]

Function

This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.[3]

References

  1. ↑ Leimeister C, Externbrink A, Klamt B, Gessler M (Jul 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mechanisms of Development. 85 (1–2): 173–7. doi:10.1016/S0925-4773(99)00080-5. PMID 10415358.
  2. ↑ Kokubo H, Lun Y, Johnson RL (Jul 1999). "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split". Biochemical and Biophysical Research Communications. 260 (2): 459–65. doi:10.1006/bbrc.1999.0880. PMID 10403790.
  3. ↑ 3.0 3.1 "Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=HEY1&oldid=1523661"