Gs alpha subunit
| GNAS complex locus | |
|---|---|
| Identifiers | |
| Symbol | GNAS |
| Alt. symbols | GNAS1 |
| Entrez | 2778 |
| HUGO | 4392 |
| OMIM | 139320 |
| RefSeq | NM_000516 |
| UniProt | Q5JWF2 |
| Other data | |
| Locus | Chr. 20 q13.2-13.3 |
Overview
The Gs alpha subunit (or Gs protein) is a heterotrimeric G protein subunit which activates adenylate cyclase.
Receptors
The G-protein coupled receptors that couple to this kind of G-protein are for example:
- 5-HT receptors type 4 and 7
- D1-like dopamine receptors
- β-adrenergic receptors
- M1 receptor (primarily Gq-coupled)
- Prostaglandin D2 receptor
- Adenosine receptor A2a and A2b
- Calcitonin receptor
- Calcitonin gene-related peptide receptor
Function
The general function of Gs is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of Gs is thus found in function of cAMP-dependent protein kinase.
See also
External links
- G(s)alpha at the US National Library of Medicine Medical Subject Headings (MeSH)
- GNAS+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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