Granulomatosis with polyangiitis laboratory findings: Difference between revisions
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==Overview== | |||
Laboratory findings consistent with the diagnosis of Granulomatosis with polyangiitis include, anti-neutrophil cytoplasmic antibody, elevated blood urea nitrogen, elevated creatinine serum, erythrocyte sedimentation rate, C reactive protein, proteinuria, microscopic hematuria, and red blood casts. | |||
==Laboratory Findings== | |||
Laboratory findings consistent with the diagnosis of Granulomatosis with polyangiitis include, anti-neutrophil cytoplasmic antibody, elevated blood urea nitrogen, elevated creatinine serum, erythrocyte sedimentation rate, C reactive protein, proteinuria, microscopic hematuria, and red blood casts. | |||
===Blood Work-Up=== | |||
* [[Complete blood count]] | |||
* [[Serum Creatinine]] | |||
* [[Blood urea nitrogen]] | |||
* [[Anti-neutrophil cytoplasmic antibody|Anti-neutrophil cytoplasmic antibody test]] | |||
** Anti PR3 | |||
===Urinalysis=== | |||
* [[Proteinuria]] | |||
* [[Microscopic hematuria]] | |||
* Red cell casts | |||
===Renal Biopsy=== | |||
Renal biopsy is the gold standard in establishing Granulomatosis with polyangiitis.<ref name="pmid20616173">{{cite journal| author=Berden AE, Ferrario F, Hagen EC, Jayne DR, Jennette JC, Joh K et al.| title=Histopathologic classification of ANCA-associated glomerulonephritis. | journal=J Am Soc Nephrol | year= 2010 | volume= 21 | issue= 10 | pages= 1628-36 | pmid=20616173 | doi=10.1681/ASN.2010050477 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20616173 }} </ref> Renal biopsy reveals under [[electron microscopy]]: | |||
* Subendothelial [[edema]] | |||
* Microthrombosis, and | |||
* [[Degranulation]] of [[neutrophils]]. | |||
Under light microscopy, necrotizing and crescentic glomerulonephritis is seen. <ref name="pmid11591101">{{cite journal| author=Bajema IM, Hagen EC, Ferrario F, de Heer E, Bruijn JA| title=Immunopathological aspects of systemic vasculitis. | journal=Springer Semin Immunopathol | year= 2001 | volume= 23 | issue= 3 | pages= 253-65 | pmid=11591101 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11591101 }} </ref> | |||
==References== | ==References== | ||
Latest revision as of 20:22, 4 April 2018
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Granulomatosis with polyangiitis Microchapters |
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Differentiating Granulomatosis with polyangiitis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]Amandeep Singh M.D.[4]
Overview
Laboratory findings consistent with the diagnosis of Granulomatosis with polyangiitis include, anti-neutrophil cytoplasmic antibody, elevated blood urea nitrogen, elevated creatinine serum, erythrocyte sedimentation rate, C reactive protein, proteinuria, microscopic hematuria, and red blood casts.
Laboratory Findings
Laboratory findings consistent with the diagnosis of Granulomatosis with polyangiitis include, anti-neutrophil cytoplasmic antibody, elevated blood urea nitrogen, elevated creatinine serum, erythrocyte sedimentation rate, C reactive protein, proteinuria, microscopic hematuria, and red blood casts.
Blood Work-Up
- Complete blood count
- Serum Creatinine
- Blood urea nitrogen
- Anti-neutrophil cytoplasmic antibody test
- Anti PR3
Urinalysis
- Proteinuria
- Microscopic hematuria
- Red cell casts
Renal Biopsy
Renal biopsy is the gold standard in establishing Granulomatosis with polyangiitis.[1] Renal biopsy reveals under electron microscopy:
- Subendothelial edema
- Microthrombosis, and
- Degranulation of neutrophils.
Under light microscopy, necrotizing and crescentic glomerulonephritis is seen. [2]
References
- ↑ Berden AE, Ferrario F, Hagen EC, Jayne DR, Jennette JC, Joh K; et al. (2010). "Histopathologic classification of ANCA-associated glomerulonephritis". J Am Soc Nephrol. 21 (10): 1628–36. doi:10.1681/ASN.2010050477. PMID 20616173.
- ↑ Bajema IM, Hagen EC, Ferrario F, de Heer E, Bruijn JA (2001). "Immunopathological aspects of systemic vasculitis". Springer Semin Immunopathol. 23 (3): 253–65. PMID 11591101.