Gallstone disease future or investigational therapies: Difference between revisions

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==Overview==
==Overview==


Electrohydraulic lithotripsy is the latest advancement in the removal of gallstones in a nonsurgical manner boasting success rates of over 90%.<ref name="pmid2335279">{{cite journal |vauthors=Siegel JH, Ben-Zvi JS, Pullano WE |title=Endoscopic electrohydraulic lithotripsy |journal=Gastrointest. Endosc. |volume=36 |issue=2 |pages=134–6 |year=1990 |pmid=2335279 |doi= |url=}}</ref><ref name="pmid8519238">{{cite journal |vauthors=Binmoeller KF, Brückner M, Thonke F, Soehendra N |title=Treatment of difficult bile duct stones using mechanical, electrohydraulic and extracorporeal shock wave lithotripsy |journal=Endoscopy |volume=25 |issue=3 |pages=201–6 |year=1993 |pmid=8519238 |doi=10.1055/s-2007-1010293 |url=}}</ref>
Electrohydraulic lithotripsy (EHL) is the latest advancement in the removal of gallstones in a nonsurgical manner. EHL reportedly has success rates of over 90%.
 
==Future or Investigational Therapies==
==Future or Investigational Therapies==


*Electrohydraulic lithotripsy (EHL) works on the same principle as [[Endoscopic retrograde cholangiopancreatography|ERCP]].  
*Electrohydraulic lithotripsy (EHL) works on the same principle as [[Endoscopic retrograde cholangiopancreatography|ERCP]].<ref name="pmid2335279">{{cite journal |vauthors=Siegel JH, Ben-Zvi JS, Pullano WE |title=Endoscopic electrohydraulic lithotripsy |journal=Gastrointest. Endosc. |volume=36 |issue=2 |pages=134–6 |year=1990 |pmid=2335279 |doi= |url=}}</ref><ref name="pmid8519238">{{cite journal |vauthors=Binmoeller KF, Brückner M, Thonke F, Soehendra N |title=Treatment of difficult bile duct stones using mechanical, electrohydraulic and extracorporeal shock wave lithotripsy |journal=Endoscopy |volume=25 |issue=3 |pages=201–6 |year=1993 |pmid=8519238 |doi=10.1055/s-2007-1010293 |url=}}</ref><ref name="pmid8903562">{{cite journal |vauthors=Lee JG, Leung JW |title=Endoscopic management of difficult common bile duct stones |journal=Gastrointest. Endosc. Clin. N. Am. |volume=6 |issue=1 |pages=43–55 |year=1996 |pmid=8903562 |doi= |url=}}</ref>
*A digital single-operator [[Endoscopy|cholangioscope]] known as "SpyGlass" is passed through a [[Endoscopy|duodenoscope]], which is passed through the oral passage.
*A digital single-operator [[Endoscopy|cholangioscope]] known as "SpyGlass" is passed through a [[Endoscopy|duodenoscope]], which is passed through the oral passage.
*Unlike ERCP, no xrays are needed to visualise the stones.  
*Unlike [[Endoscopic retrograde cholangiopancreatography|ERCP]], no [[X-rays]] are needed to visualize the stones.  
*Once the stones are reached, a powerful burst of electrical currents are released to shatter stones.  
*Once the stones are reached, a powerful burst of electrical currents are released to shatter stones.  
*The main complicaton with EHL is that the common bile duct may be perforated.  
*The main complicaton with EHL is that the common bile duct may be [[Perforation|perforated]].  
*Bleeding may also occur, as well as injury to the surrounding epithelium.<ref name="pmid8903562">{{cite journal |vauthors=Lee JG, Leung JW |title=Endoscopic management of difficult common bile duct stones |journal=Gastrointest. Endosc. Clin. N. Am. |volume=6 |issue=1 |pages=43–55 |year=1996 |pmid=8903562 |doi= |url=}}</ref><ref name="pmid9569358">{{cite journal |vauthors=Craigie JE, Adams DB, Byme TK, Tagge EP, Tarnasky PR, Cunningham JT, Hawes RH |title=Endoscopic electrohydraulic lithotripsy in the management of pancreatobiliary lithiasis |journal=Surg Endosc |volume=12 |issue=5 |pages=405–8 |year=1998 |pmid=9569358 |doi= |url=}}</ref><ref name="pmid8836715">{{cite journal |vauthors=Adamek HE, Maier M, Jakobs R, Wessbecher FR, Neuhauser T, Riemann JF |title=Management of retained bile duct stones: a prospective open trial comparing extracorporeal and intracorporeal lithotripsy |journal=Gastrointest. Endosc. |volume=44 |issue=1 |pages=40–7 |year=1996 |pmid=8836715 |doi= |url=}}</ref><ref name="pmid10582769">{{cite journal |vauthors=Adamek HE, Schneider AR, Adamek MU, Jakobs R, Buttmann A, Benz C, Riemann JF |title=Treatment of difficult intrahepatic stones by using extracorporeal and intracorporeal lithotripsy techniques: 10 years' experience in 55 patients |journal=Scand. J. Gastroenterol. |volume=34 |issue=11 |pages=1157–61 |year=1999 |pmid=10582769 |doi= |url=}}</ref>
*[[Bleeding]] may also occur, as well as injury to the surrounding [[epithelium]].


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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[[Category:Hepatology]]
[[Category:Hepatology]]
[[Category:Surgery]]
[[Category:Surgery]]
[[Category:Primary care]]
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Latest revision as of 21:48, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]

Overview

Electrohydraulic lithotripsy (EHL) is the latest advancement in the removal of gallstones in a nonsurgical manner. EHL reportedly has success rates of over 90%.

Future or Investigational Therapies

  • Electrohydraulic lithotripsy (EHL) works on the same principle as ERCP.[1][2][3]
  • A digital single-operator cholangioscope known as "SpyGlass" is passed through a duodenoscope, which is passed through the oral passage.
  • Unlike ERCP, no X-rays are needed to visualize the stones.
  • Once the stones are reached, a powerful burst of electrical currents are released to shatter stones.
  • The main complicaton with EHL is that the common bile duct may be perforated.
  • Bleeding may also occur, as well as injury to the surrounding epithelium.

References

  1. Siegel JH, Ben-Zvi JS, Pullano WE (1990). "Endoscopic electrohydraulic lithotripsy". Gastrointest. Endosc. 36 (2): 134–6. PMID 2335279.
  2. Binmoeller KF, Brückner M, Thonke F, Soehendra N (1993). "Treatment of difficult bile duct stones using mechanical, electrohydraulic and extracorporeal shock wave lithotripsy". Endoscopy. 25 (3): 201–6. doi:10.1055/s-2007-1010293. PMID 8519238.
  3. Lee JG, Leung JW (1996). "Endoscopic management of difficult common bile duct stones". Gastrointest. Endosc. Clin. N. Am. 6 (1): 43–55. PMID 8903562.

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