Filariasis natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
If left untreated, patients with lymphatic filariasis may progress to develop [[Lymphedema|chronic lymphedema]], [[hydrocele]], skin pigmentation, and [[chyluria]]. Prognosis is generally good in early cases, but in chronic cases the disease can leave an individual severely disabled with genital damage. | If left untreated, patients with lymphatic filariasis may progress to develop [[lymphatic]] [[dilation]] and impaired [[lymphatic drainage]]. Common complications of filariasis include [[Lymphedema|chronic lymphedema]], [[hydrocele]], [[Skin pigmentation|skin pigmentation,]] and [[renal]] impairment like [[chyluria]]. Prognosis is generally good in early cases, but in chronic cases the disease can leave an individual severely disabled with [[genital]] damage. | ||
==Natural history== | ==Natural history== | ||
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==Complications== | ==Complications== | ||
Complications that may develop as a result of [[lymphatic filariasis]] include: | Complications that may develop as a result of [[lymphatic filariasis]] include: | ||
*[[Lymphedema]]: | *[[Lymphedema]]: | ||
*[[Hydrocele]]: | **[[Lymphedema]] refers to [[Edema|non-pitting edema]] in limbs due to [[chronic inflammation]] and obstruction of lymphatic vessels. | ||
*Renal involvement: Increased intestinal lymph drainage in renal vessels causes loss of lymph fluid in urine giving it milky appearance.<ref name="pmid16607704">{{cite journal| author=Franco-Paredes C, Hidron A, Steinberg J| title=A woman from British Guyana with recurrent back pain and fever. Chyluria associated with infection due to Wuchereria bancrofti. | journal=Clin Infect Dis | year= 2006 | volume= 42 | issue= 9 | pages= 1297, 1340-1 | pmid=16607704 | doi=10.1086/503263 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16607704 }} </ref> | **[[Lymphedema]] commonly occurs in upper limbs and may involve [[breasts]]. | ||
**[[Lower limb]] is a common place for [[lymphedema]] that commonly spares genitalia except [[Wuchereria bancrofti|W.bancrofti]] endemic areas.<ref name="pmid12201590">{{cite journal| author=Supali T, Wibowo H, Rückert P, Fischer K, Ismid IS et al.| title=High prevalence of Brugia timori infection in the highland of Alor Island, Indonesia. | journal=Am J Trop Med Hyg | year= 2002 | volume= 66 | issue= 5 | pages= 560-5 | pmid=12201590 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12201590 }} </ref> | |||
*[[Hydrocele]]: | |||
**[[Hydrocele]] was also reported up to 30 cm in diameter due to [[lymphedema]] in the genitalia that may lead to bacterial infection. | |||
**Some cases of filariasis of the ovary and [[mesosalpinx]] were also reported.<ref name="pmid11776512">{{cite journal| author=Sethi S, Misra K, Singh UR, Kumar D| title=Lymphatic filariasis of the ovary and mesosalpinx. | journal=J Obstet Gynaecol Res | year= 2001 | volume= 27 | issue= 5 | pages= 285-92 | pmid=11776512 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11776512 }} </ref> | |||
*[[Kidney|Renal involvement:]] | |||
**Increased [[intestinal]] lymph drainage in [[Renal veins|renal vessels]] causes loss of lymph fluid in urine giving it milky appearance.<ref name="pmid16607704">{{cite journal| author=Franco-Paredes C, Hidron A, Steinberg J| title=A woman from British Guyana with recurrent back pain and fever. Chyluria associated with infection due to Wuchereria bancrofti. | journal=Clin Infect Dis | year= 2006 | volume= 42 | issue= 9 | pages= 1297, 1340-1 | pmid=16607704 | doi=10.1086/503263 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16607704 }} </ref> | |||
==Prognosis== | ==Prognosis== | ||
* Early or mild filariasis, including acute [[inflammatory]] episodes, typically responds well to treatment. | * Early or mild filariasis, including acute [[inflammatory]] episodes, typically responds well to treatment. | ||
* It can be reduced and prevented with simple measures of hygiene, skin care, exercise, and elevation of affected limbs, chronic infection does not. | * It can be reduced and [[Prevention|prevented]] with simple measures of [[hygiene]], [[Skin|skin care]], [[exercise]], and elevation of affected limbs, chronic infection does not. | ||
* Filariasis does not commonly lead to mortality, however, disease can leave an individual severely disabled with genital damage or elephantiasis. | * Filariasis does not commonly lead to [[mortality]], however, disease can leave an individual severely disabled with [[genital]] damage or [[elephantiasis]]. | ||
* Lymphatic filariasis is the second leading cause of disability worldwide with 40 million persons suffering from complications that limit occupational activities, educational and employment opportunities, and mobility.<ref name="pmid21887884">{{cite journal| author=| title=Global Programme to eliminate lymphatic filariasis: progress report on mass drug administration, 2010. | journal=Wkly Epidemiol Rec | year= 2011 | volume= 86 | issue= 35 | pages= 377-88 | pmid=21887884 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21887884 }} </ref> | * Lymphatic filariasis is the second leading cause of disability worldwide with 40 million persons suffering from complications that limit occupational activities, educational and employment opportunities, and mobility.<ref name="pmid21887884">{{cite journal| author=| title=Global Programme to eliminate lymphatic filariasis: progress report on mass drug administration, 2010. | journal=Wkly Epidemiol Rec | year= 2011 | volume= 86 | issue= 35 | pages= 377-88 | pmid=21887884 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21887884 }} </ref> | ||
Latest revision as of 15:48, 17 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]
Overview
If left untreated, patients with lymphatic filariasis may progress to develop lymphatic dilation and impaired lymphatic drainage. Common complications of filariasis include chronic lymphedema, hydrocele, skin pigmentation, and renal impairment like chyluria. Prognosis is generally good in early cases, but in chronic cases the disease can leave an individual severely disabled with genital damage.
Natural history
Lymphatic filariasis can be asymptomatic or symptomatic. Symptoms may include acute adenolymphangitis, filarial fever, and tropical pulmonary eosinophilia. If left untreated, disease can progress to lymphatic dilatation, abnormalities in lymphatic drainage, and microscopic hematuria and proteinuria.
Complications
Complications that may develop as a result of lymphatic filariasis include:
- Lymphedema:
- Lymphedema refers to non-pitting edema in limbs due to chronic inflammation and obstruction of lymphatic vessels.
- Lymphedema commonly occurs in upper limbs and may involve breasts.
- Lower limb is a common place for lymphedema that commonly spares genitalia except W.bancrofti endemic areas.[1]
- Hydrocele:
- Hydrocele was also reported up to 30 cm in diameter due to lymphedema in the genitalia that may lead to bacterial infection.
- Some cases of filariasis of the ovary and mesosalpinx were also reported.[2]
- Renal involvement:
- Increased intestinal lymph drainage in renal vessels causes loss of lymph fluid in urine giving it milky appearance.[3]
Prognosis
- Early or mild filariasis, including acute inflammatory episodes, typically responds well to treatment.
- It can be reduced and prevented with simple measures of hygiene, skin care, exercise, and elevation of affected limbs, chronic infection does not.
- Filariasis does not commonly lead to mortality, however, disease can leave an individual severely disabled with genital damage or elephantiasis.
- Lymphatic filariasis is the second leading cause of disability worldwide with 40 million persons suffering from complications that limit occupational activities, educational and employment opportunities, and mobility.[4]
References
- ↑ Supali T, Wibowo H, Rückert P, Fischer K, Ismid IS; et al. (2002). "High prevalence of Brugia timori infection in the highland of Alor Island, Indonesia". Am J Trop Med Hyg. 66 (5): 560–5. PMID 12201590.
- ↑ Sethi S, Misra K, Singh UR, Kumar D (2001). "Lymphatic filariasis of the ovary and mesosalpinx". J Obstet Gynaecol Res. 27 (5): 285–92. PMID 11776512.
- ↑ Franco-Paredes C, Hidron A, Steinberg J (2006). "A woman from British Guyana with recurrent back pain and fever. Chyluria associated with infection due to Wuchereria bancrofti". Clin Infect Dis. 42 (9): 1297, 1340–1. doi:10.1086/503263. PMID 16607704.
- ↑ "Global Programme to eliminate lymphatic filariasis: progress report on mass drug administration, 2010". Wkly Epidemiol Rec. 86 (35): 377–88. 2011. PMID 21887884.