Fibroma differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Differential Diagnosis

Type of Fibroma Differential Diagnosis
Ovarian fibroma
  • Large pedunculated subserosal uterine leiomyoma
  • Thecoma
  • Leiomyoma
  • Fibrosarcoma
  • Metastatic metaplastic carcinoma
  • Endometriosis with extensive fibrosis.
Non-ossifying fibroma
  • Fibrous cortical defect
  • Aneurysmal bone cyst
  • Chondromyxoid fibroma
  • Fibrous dysplasia
  • Desmoplastic fibroma
Ossifying Fibroma
  • Fibrous dysplasia
  • Adamantinoma
  • Osteoid osteoma
Chondromyxoid Fibroma
  • Aneurysmal bone cyst (ABC)
  • Giant cell tumour of bone (GCT)
  • Non ossifying fibroma
  • Chondroblastoma
  • Chondrosarcoma
  • Phosphaturic mesenchymal tumor
Desmoplastic Fibroma
  • Giant cell tumour of bone (GCT)
  • Non ossifying fibroma (NOF)
  • Fibrous dysplasia
  • Low grade fibrosarcoma.
Pleural Fibroma

Considerations for extremely well defined lesions include:

  • Pleural lipoma
  • Pleural fibrosarcoma
  • Intercostal nerve neurilemoma (schwannoma)

If not extremely well defined, broader considerations include:

  • Organised inflammation
  • Peripheral bronchogenic carcinoma
  • Solitary pleural metastasis

Also consider the differential for a single pleural mass which includes the following:

  • Pleural tumours
    • Solitary fibrous tumour of the pleura (pleural fibroma)
    • Mesothelioma
    • Localised mediastinal malignant mesothelioma
  • Metastatic pleural disease, particularly from adenocarcinomas
  • Pleural lymphoma
  • Invasive thymoma
  • Lipoma
  • Pleural effusion
  • Empyema
  • Haemothorax
  • Ewing sarcoma of chest wall, Askin tumour
  • Intercostal nerve neurilemmoma
  • Splenosis
  • Tuberculosis
Renal Medullary Fibroma
  • Renal myxoma

References

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