Fibroma differential diagnosis: Difference between revisions

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__NOTOC__
__NOTOC__
{{Fibroma}}
[[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Fibroma]]
{{CMG}}; {{AE}} {{Simrat}}
{{CMG}}; {{AE}}{{M.N}}, {{Simrat}}
==Overview==
==Overview==
Oral fibroma must be differentiated from squamous papilloma, giant cell fibroma, neurofibroma, peripheral giant cell granuloma, mucocele, and benign and malignant salivary gland tumors. Non-ossifying fibroma must be differentiated from fibrous cortical defect, aneurysmal bone cyst, chondromyxoid fibroma, fibrous dysplasia, desmoplastic fibroma,
Oral fibroma must be differentiated from [[squamous papilloma]], [[giant cell fibroma]], [[neurofibroma]], [[peripheral giant cell]] granuloma, [[mucocele]], and benign and [[malignant salivary gland tumors]]. [[Non-ossifying fibroma]] must be differentiated from [[fibrous cortical defect]], [[aneurysmal bone cyst]], [[chondromyxoid fibroma]], [[fibrous dysplasia]], [[desmoplastic fibroma]], [[giant cell tumor]] of bone, and spindle cell lesions of bone. [[Ossifying fibroma]] must be differentiated from ossifying fibroma, [[fibrous dysplasia]], [[adamantinoma]], and [[osteoid osteoma]]. [[Chondromyxoid fibroma]] must be differentiated from [[aneurysmal bone cyst]] (ABC), [[giant cell tumor]] of bone (GCT), [[non-ossifying fibroma]], [[chondroblastoma]], [[chondrosarcoma]], and phosphaturic mesenchymal tumor. [[Desmoplastic fibroma]] must be differentiated from [[giant cell tumor]] of bone (GCT), [[non- ossifying fibroma]] (NOF), fibrous dysplasia, low grade fibrosarcoma, unicameral bone cyst, chondromyxoid fibroma, periosteal desmoids, eosinophilic granuloma, low-grade intraosseous osteosarcoma, [[adamantinoma]], and distant metastasis.
giant cell tumour of bone, and spindle cell lesions of bone. Ossifying fibroma must be differentiated from ossifying fibroma, fibrous dysplasia, adamantinoma, and osteoid osteoma. Chondromyxoid fibroma must be differentiated from aneurysmal bone cyst (ABC), giant cell tumour of bone (GCT), non ossifying fibroma, chondroblastoma, chondrosarcoma, and phosphaturic mesenchymal tumor. Desmoplastic fibroma must be differentiated from giant cell tumour of bone (GCT), non ossifying fibroma (NOF), fibrous dysplasia, low grade fibrosarcoma, unicameral bone cyst, chondromyxoid fibroma, periosteal desmoids, eosinophilic granuloma, low-grade intraosseous osteosarcoma, adamantinoma, and distant metastasis.<ref name="radio"> Fibroma. Radiopedia(2015) http://radiopaedia.org/search?utf8=%E2%9C%93&q=fibroma&scope=all Accessed on March 12, 2016</ref><ref name="radio"> Fibroma. Radiopedia(2015) http://radiopaedia.org/articles/non-ossifying-fibroma-1 Accessed on March 12, 2016</ref><ref name="radio"> Fibroma. Radiopedia(2015) http://radiopaedia.org/articles/ovarian-fibroma Accessed on March 12, 2016</ref> <ref name="radio"> Fibroma. Radiopedia(2015) http://radiopaedia.org/articles/ossifying-fibroma Accessed on March 12, 2016</ref><ref name="radio"> Fibroma. Radiopedia(2015) http://radiopaedia.org/articles/chondromyxoid-fibroma Accessed on March 12, 2016</ref><ref name="radio"> Fibroma. Radiopedia(2015) http://radiopaedia.org/articles/cemento-ossifying-fibroma Accessed on March 12, 2016</ref><ref name="radio"> Fibroma. Radiopedia(2015) http://radiopaedia.org/articles/uterine-leiomyoma Accessed on March 12, 2016</ref>


==Differential Diagnosis==
==Differential Diagnosis==
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| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Large pedunculated subserosal uterine leiomyoma
*Large pedunculated subserosal uterine leiomyoma
*Thecoma  
*[[Thecoma]]
*Leiomyoma  
*[[Leiomyoma]]
*Fibrosarcoma
*[[Fibrosarcoma]]
*Metastatic metaplastic carcinoma  
*Metastatic metaplastic carcinoma  
*Endometriosis with extensive fibrosis.
*Endometriosis with extensive fibrosis.
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Non-ossifying fibroma
:[[Non-ossifying fibroma]]
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Fibrous cortical defect
*[[Fibrous cortical defect]]
*Aneurysmal bone cyst
*[[Aneurysmal bone cyst]]
*Chondromyxoid fibroma
*[[Chondromyxoid fibroma]]
*Fibrous dysplasia
*Fibrous dysplasia
*Desmoplastic fibroma
*[[Desmoplastic fibroma]]
*Giant cell tumour of bone  
*[[Giant cell tumor]] of bone  
*Spindle cell lesions of bone
*Spindle cell lesions of bone
|-
|-
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:Ossifying Fibroma
:Ossifying Fibroma
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Fibrous dysplasia
*[[Fibrous dysplasia]]
*Adamantinoma
*[[Adamantinoma]]
*Osteoid osteoma
*[[Osteoid osteoma]]
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Chondromyxoid Fibroma
:[[Chondromyxoid Fibroma]]
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Aneurysmal bone cyst (ABC)
*[[Aneurysmal bone cyst]] (ABC)
*Giant cell tumour of bone (GCT)
*[[Giant cell tumor]] of bone (GCT)
*Non ossifying fibroma
*[[Non ossifying fibroma]]
*Chondroblastoma
*[[Chondroblastoma]]
*Chondrosarcoma
*[[Chondrosarcoma]]
*Phosphaturic mesenchymal tumor
*Phosphaturic mesenchymal tumor
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Desmoplastic Fibroma
:[[Desmoplastic Fibroma]]
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Giant cell tumour of bone (GCT)
*[[Giant cell tumor]] of bone (GCT)
*Non ossifying fibroma (NOF)
*[[Non ossifying fibroma]] (NOF)
*Fibrous dysplasia  
*[[Fibrous dysplasia]]
*Low grade fibrosarcoma
*Low grade [[fibrosarcoma]]
*Unicameral bone cyst
*Unicameral bone cyst
*Chondromyxoid fibroma
*[[Chondromyxoid fibroma]]
*Periosteal desmoids
*Periosteal desmoids
*Eosinophilic granuloma
*Eosinophilic granuloma
*Low-grade intraosseous osteosarcoma
*Low-grade intraosseous osteosarcoma
*Adamantinoma
*[[Adamantinoma]]
*Distant metastasis  
*Distant metastasis  
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Pleural Fibroma
:[[Pleural Fibroma]]
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
Considerations for extremely well defined lesions include:
Considerations for extremely well defined lesions include:
*Pleural lipoma
*[[Pleural lipoma]]
*Pleural fibrosarcoma
*Pleural [[fibrosarcoma]]
*Intercostal nerve neurilemoma (schwannoma)
*[[Intercostal nerve neurilemoma]] (schwannoma)
If not extremely well defined, broader considerations include:
If not extremely well defined, broader considerations include:
*Organised inflammation  
*Organised inflammation  
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*Solitary pleural metastasis
*Solitary pleural metastasis
Also consider the differential for a single pleural mass which includes the following:
Also consider the differential for a single pleural mass which includes the following:
*Pleural tumours
*Pleural tumors
**Solitary fibrous tumour of the pleura (pleural fibroma)
**Solitary fibrous tumour of the pleura (pleural fibroma)
**Mesothelioma
**Mesothelioma
**Localised mediastinal malignant mesothelioma
**Localised mediastinal malignant mesothelioma
*Metastatic pleural disease, particularly from adenocarcinomas
*Metastatic pleural disease, particularly from [[adenocarcinomas]]
*Pleural lymphoma
*Pleural lymphoma
*Invasive thymoma
*Invasive thymoma
*Lipoma
*Lipoma
*Pleural effusion  
*[[Pleural effusion]]
*Empyema
*[[Empyema]]
*Haemothorax
*[[Haemothorax]]
*Ewing sarcoma of chest wall, Askin tumour
*[[Ewing sarcoma]] of chest wall, Askin tumor
*Intercostal nerve neurilemmoma
*Intercostal nerve neurilemmoma
*Splenosis
*Splenosis
*Tuberculosis
*[[Tuberculosis]]
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Renal Medullary Fibroma
:[[Renal Medullary Fibroma]]
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Renal myxoma
*Renal myxoma
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:Cemento-ossifying Fibroma
:Cemento-ossifying Fibroma
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Fibrous dysplasia
*[[Fibrous dysplasia]]
*Ameloblastic fibro odontoma
*Ameloblastic fibro odontoma
*Odontoma
*[[Odontoma]]
*Calcifying epithelial odontogenic tumour (Pindborg tumour)
*Calcifying epithelial odontogenic tumour (Pindborg tumour)
*Odontogenic cyst
*Odontogenic cyst
*Calcifying odontogenic cyst (Gorlin cyst)
*Calcifying odontogenic cyst (Gorlin cyst)
*Osteochondroma
*[[Osteochondroma]]
*Osteosarcoma
*[[Osteosarcoma]]
*Chondrosarcoma
*[[Chondrosarcoma]]
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Desmoplastic fibroblastoma (Collagenous fibroma)
:[[Desmoplastic fibroblastoma]] (Collagenous fibroma)
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Fibromatosis
*[[Fibromatosis]]
*Elastofibroma
*[[Elastofibroma]]
*Low-grade fibromyxoid sarcoma.
*Low-grade fibromyxoid sarcoma.
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Ameloblastic Fibroma
:[[Ameloblastic Fibroma]]
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Ameloblastoma
*Ameloblastoma
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Giant cell fibroma
:[[Giant cell fibroma]]
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Squamous Papilloma
*[[Squamous Papilloma]]
*Irritation fibroma
*Irritation fibroma
*Pyogenic granuloma
*Pyogenic granuloma
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:Oral Fibroma
:Oral Fibroma
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Squamous Papilloma
*[[Squamous Papilloma]]
*Giant cell fibroma
*[[Giant cell fibroma]]
*Neurofibroma
*[[Neurofibroma]]
*Peripheral giant cell granuloma
*Peripheral giant cell granuloma
*Mucocele
*[[Mucocele]]
*Benign and malignant salivary gland tumors  
*Benign and [[malignant salivary gland]] tumors  
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Uterine Fibroma
:[[Uterine Fibroma]]
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Uterine leiomyosarcoma
*[[Uterine leiomyosarcoma]]
*Uterine smooth muscle tumours of uncertain malignant potential
*Uterine smooth muscle tumors of uncertain malignant potential
*Uterine lipoleiomyoma
*Uterine lipoleiomyoma
*Ovarian masses
*Ovarian masses
*Focal myometrial contraction (Braxton Hicks contraction): especially if seen during pregnancy
*Focal myometrial contraction (Braxton Hicks contraction): especially if seen during pregnancy
*Focal adenomyosis  
*Focal [[adenomyosis]]
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Peripheral odontogenic fibroma
:[[Peripheral odontogenic fibroma]]
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Inflammatory gingival hyperplasia
*Inflammatory gingival hyperplasia
*Peripheral cemento-ossifying fibroma
*Peripheral [[cemento-ossifying fibroma]]
*Peripheral giant cell granuloma.
*Peripheral [[giant cell granuloma]]
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Peripheral odontogenic fibroma
:[[Elastofibroma]]
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Spindle cell lipoma
*Spindle cell lipoma
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[[Category:Oncology]]  
[[Category:Oncology]]  
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Up-To-Date]]
[[Category:Medicine]]

Latest revision as of 16:36, 5 July 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maneesha Nandimandalam, M.B.B.S.[2], Simrat Sarai, M.D. [3]

Overview

Oral fibroma must be differentiated from squamous papilloma, giant cell fibroma, neurofibroma, peripheral giant cell granuloma, mucocele, and benign and malignant salivary gland tumors. Non-ossifying fibroma must be differentiated from fibrous cortical defect, aneurysmal bone cyst, chondromyxoid fibroma, fibrous dysplasia, desmoplastic fibroma, giant cell tumor of bone, and spindle cell lesions of bone. Ossifying fibroma must be differentiated from ossifying fibroma, fibrous dysplasia, adamantinoma, and osteoid osteoma. Chondromyxoid fibroma must be differentiated from aneurysmal bone cyst (ABC), giant cell tumor of bone (GCT), non-ossifying fibroma, chondroblastoma, chondrosarcoma, and phosphaturic mesenchymal tumor. Desmoplastic fibroma must be differentiated from giant cell tumor of bone (GCT), non- ossifying fibroma (NOF), fibrous dysplasia, low grade fibrosarcoma, unicameral bone cyst, chondromyxoid fibroma, periosteal desmoids, eosinophilic granuloma, low-grade intraosseous osteosarcoma, adamantinoma, and distant metastasis.

Differential Diagnosis

Type of Fibroma Differential Diagnosis
Ovarian fibroma
  • Large pedunculated subserosal uterine leiomyoma
  • Thecoma
  • Leiomyoma
  • Fibrosarcoma
  • Metastatic metaplastic carcinoma
  • Endometriosis with extensive fibrosis.
Non-ossifying fibroma
Ossifying Fibroma
Chondromyxoid Fibroma
Desmoplastic Fibroma
Pleural Fibroma

Considerations for extremely well defined lesions include:

If not extremely well defined, broader considerations include:

  • Organised inflammation
  • Peripheral bronchogenic carcinoma
  • Solitary pleural metastasis

Also consider the differential for a single pleural mass which includes the following:

Renal Medullary Fibroma
  • Renal myxoma
Cemento-ossifying Fibroma
Desmoplastic fibroblastoma (Collagenous fibroma)
Ameloblastic Fibroma
  • Ameloblastoma
Giant cell fibroma
Oral Fibroma
Uterine Fibroma
  • Uterine leiomyosarcoma
  • Uterine smooth muscle tumors of uncertain malignant potential
  • Uterine lipoleiomyoma
  • Ovarian masses
  • Focal myometrial contraction (Braxton Hicks contraction): especially if seen during pregnancy
  • Focal adenomyosis
Peripheral odontogenic fibroma
Elastofibroma
  • Spindle cell lipoma
  • Nuchal-type fibroma
  • Fibromatosis colli

References

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