Fibroadenoma natural history, complications and prognosis: Difference between revisions
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* It takes about 12 months for most fibroadenomas to gain a size of 2 to 3 cm, wherefore they remain unchanged for several years.<ref name="pmid9754521">{{cite journal |vauthors=Greenberg R, Skornick Y, Kaplan O |title=Management of breast fibroadenomas |journal=J Gen Intern Med |volume=13 |issue=9 |pages=640–5 |date=September 1998 |pmid=9754521 |pmc=1497021 |doi= |url=}}</ref> | * It takes about 12 months for most fibroadenomas to gain a size of 2 to 3 cm, wherefore they remain unchanged for several years.<ref name="pmid9754521">{{cite journal |vauthors=Greenberg R, Skornick Y, Kaplan O |title=Management of breast fibroadenomas |journal=J Gen Intern Med |volume=13 |issue=9 |pages=640–5 |date=September 1998 |pmid=9754521 |pmc=1497021 |doi= |url=}}</ref> | ||
* The lifetime of a fibroadenoma is about 15 years.<ref name="pmid9754521">{{cite journal |vauthors=Greenberg R, Skornick Y, Kaplan O |title=Management of breast fibroadenomas |journal=J Gen Intern Med |volume=13 |issue=9 |pages=640–5 |date=September 1998 |pmid=9754521 |pmc=1497021 |doi= |url=}}</ref> | * The lifetime of a fibroadenoma is about 15 years.<ref name="pmid9754521">{{cite journal |vauthors=Greenberg R, Skornick Y, Kaplan O |title=Management of breast fibroadenomas |journal=J Gen Intern Med |volume=13 |issue=9 |pages=640–5 |date=September 1998 |pmid=9754521 |pmc=1497021 |doi= |url=}}</ref> | ||
* After 5 years, there is approximately 50% likelihood of resolution of a fibroadenoma. Among the 50% not likely to resolve spontaneously, about 25% will not change and 25% will enlarge in size during follow up<ref name="pmid9754521">{{cite journal |vauthors=Greenberg R, Skornick Y, Kaplan O |title=Management of breast fibroadenomas |journal=J Gen Intern Med |volume=13 |issue=9 |pages=640–5 |date=September 1998 |pmid=9754521 |pmc=1497021 |doi= |url=}}</ref> | * After 5 years, there is approximately 50% likelihood of resolution of a fibroadenoma. Among the 50% not likely to resolve spontaneously, about 25% will not change and 25% will enlarge in size during follow up.<ref name="pmid9754521">{{cite journal |vauthors=Greenberg R, Skornick Y, Kaplan O |title=Management of breast fibroadenomas |journal=J Gen Intern Med |volume=13 |issue=9 |pages=640–5 |date=September 1998 |pmid=9754521 |pmc=1497021 |doi= |url=}}</ref> | ||
* Most fibroadenomas decrease in size via loss of cellularity or infarction with resultant calcification and hyalinization. Some fibroadenomas may remain dormant without any change in size while others may grow slowly in size.<ref name="pmid26366109">{{cite journal |vauthors=Lee M, Soltanian HT |title=Breast fibroadenomas in adolescents: current perspectives |journal=Adolesc Health Med Ther |volume=6 |issue= |pages=159–63 |date=2015 |pmid=26366109 |pmc=4562655 |doi=10.2147/AHMT.S55833 |url=}}</ref> | * Most fibroadenomas decrease in size via loss of cellularity or infarction with resultant calcification and hyalinization. Some fibroadenomas may remain dormant without any change in size while others may grow slowly in size.<ref name="pmid26366109">{{cite journal |vauthors=Lee M, Soltanian HT |title=Breast fibroadenomas in adolescents: current perspectives |journal=Adolesc Health Med Ther |volume=6 |issue= |pages=159–63 |date=2015 |pmid=26366109 |pmc=4562655 |doi=10.2147/AHMT.S55833 |url=}}</ref> | ||
* The risk of [[malignant]] transformation is extremely low, where it has been reported in only 0.0125% of the cases. | * The risk of [[malignant]] transformation is extremely low, where it has been reported in only 0.0125% of the cases. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Most patients with fibroadenoma are asymptomatic. If left untreated, patients with fibroadenoma may progress to develop a painless, mobile, and well-circumscribe breast lump. Fibroadenoma is a benign tumor that rarely develops any complications. Fibroadenomas commonly enlarge during pregnancy and involute after the age of menopause. The prognosis is generally excellent, and the 5-year survival rate of patients with fibroadenoma is almost equal to the normal population.[1]
Natural History
- It takes about 12 months for most fibroadenomas to gain a size of 2 to 3 cm, wherefore they remain unchanged for several years.[2]
- The lifetime of a fibroadenoma is about 15 years.[2]
- After 5 years, there is approximately 50% likelihood of resolution of a fibroadenoma. Among the 50% not likely to resolve spontaneously, about 25% will not change and 25% will enlarge in size during follow up.[2]
- Most fibroadenomas decrease in size via loss of cellularity or infarction with resultant calcification and hyalinization. Some fibroadenomas may remain dormant without any change in size while others may grow slowly in size.[3]
- The risk of malignant transformation is extremely low, where it has been reported in only 0.0125% of the cases.
- Fibroadenomas commonly enlarge during pregnancy and involute after the age of menopause.
- More than 70% of fibroadenomas present as a single mass, and 10%–25% of fibroadenomas present as multiple masses.[3]
Complications
- Fibroadenoma is a benign tumor that rarely develops any complications.[1]
Prognosis
- The prognosis is generally excellent, and the 5-year survival rate of patients with fibroadenoma is almost equal to the normal population.[1]
- In adolescents, the mass regresses completely between 10 and 40% of the time.[4]
- Though not yet quantifiable, patients with fibroadenoma may be at increased risk of developing invasive breast cancer later in life. This risk is increased in women with complex fibroadenomas (fibroadenomas with cysts, sclerosing adenosis, epithelial calcifications, papillary apocrine changes, or more than 3mm in diameter), proliferative disease, or a family history of breast cancer.[4][5]
References
- ↑ 1.0 1.1 1.2 Fibroadenoma. Radiopaedia (2015) http://radiopaedia.org/articles/fibroadenoma-of-the-breast-1 Accessed on January, 29 2016
- ↑ 2.0 2.1 2.2 Greenberg R, Skornick Y, Kaplan O (September 1998). "Management of breast fibroadenomas". J Gen Intern Med. 13 (9): 640–5. PMC 1497021. PMID 9754521.
- ↑ 3.0 3.1 Lee M, Soltanian HT (2015). "Breast fibroadenomas in adolescents: current perspectives". Adolesc Health Med Ther. 6: 159–63. doi:10.2147/AHMT.S55833. PMC 4562655. PMID 26366109.
- ↑ 4.0 4.1 Cerrato F, Labow BI (February 2013). "Diagnosis and management of fibroadenomas in the adolescent breast". Semin Plast Surg. 27 (1): 23–5. doi:10.1055/s-0033-1343992. PMC 3706050. PMID 24872735.
- ↑ Dupont WD, Page DL, Parl FF, Vnencak-Jones CL, Plummer WD, Rados MS, Schuyler PA (July 1994). "Long-term risk of breast cancer in women with fibroadenoma". N. Engl. J. Med. 331 (1): 10–5. doi:10.1056/NEJM199407073310103. PMID 8202095.