Fibroadenoma differential diagnosis: Difference between revisions

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Fibroadenoma must be differentiated from other diseases that cause a similar clinical presentation, such as phyllodes tumor, hamartoma, and adenomyoepithelioma.><ref name="patho">Fibroadenoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Fibroadenoma Accessed on January, 29 2016</ref><ref name="patho2">Breast-nonmalignant-Fibroadenoma. PathologyOutlines (2015) http://www.pathologyoutlines.com/topic/breastfibroadenoma.html Accessed on January, 29 2016</ref>  
Fibroadenoma must be differentiated from other diseases that cause a similar clinical presentation, such as phyllodes tumor, hamartoma, and adenomyoepithelioma.><ref name="patho">Fibroadenoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Fibroadenoma Accessed on January, 29 2016</ref><ref name="patho2">Breast-nonmalignant-Fibroadenoma. PathologyOutlines (2015) http://www.pathologyoutlines.com/topic/breastfibroadenoma.html Accessed on January, 29 2016</ref>  
==Differentiating Fibroadenoma from other Diseases==
==Differentiating Fibroadenoma from other Diseases==
must be differentiated from other diseases that cause [[breast pain]] and [[swelling]] as shown below:<ref name="pmid16713771">{{cite journal| author=Greydanus DE, Matytsina L, Gains M| title=Breast disorders in children and adolescents. | journal=Prim Care | year= 2006 | volume= 33 | issue= 2 | pages= 455-502 | pmid=16713771 | doi=10.1016/j.pop.2006.02.002 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16713771  }} </ref><ref name="pmid23450563">{{cite journal| author=Jahanfar S, Ng CJ, Teng CL| title=Antibiotics for mastitis in breastfeeding women. | journal=Cochrane Database Syst Rev | year= 2013 | volume=  | issue= 2 | pages= CD005458 | pmid=23450563 | doi=10.1002/14651858.CD005458.pub3 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23450563  }} </ref> <ref name="pmid24791941">{{cite journal| author=Lam E, Chan T, Wiseman SM| title=Breast abscess: evidence based management recommendations. | journal=Expert Rev Anti Infect Ther | year= 2014 | volume= 12 | issue= 7 | pages= 753-62 | pmid=24791941 | doi=10.1586/14787210.2014.913982 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24791941  }} </ref><ref name="pmid11250736">{{cite journal| author=Kleer CG, van Golen KL, Merajver SD| title=Molecular biology of breast cancer metastasis. Inflammatory breast cancer: clinical syndrome and molecular determinants. | journal=Breast Cancer Res | year= 2000 | volume= 2 | issue= 6 | pages= 423-9 | pmid=11250736 | doi=10.1186/bcr89 | pmc=138665 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11250736  }} </ref><ref name="pmid20603440">{{cite journal| author=Dawood S, Merajver SD, Viens P, Vermeulen PB, Swain SM, Buchholz TA et al.| title=International expert panel on inflammatory breast cancer: consensus statement for standardized diagnosis and treatment. | journal=Ann Oncol | year= 2011 | volume= 22 | issue= 3 | pages= 515-23 | pmid=20603440 | doi=10.1093/annonc/mdq345 | pmc=3105293 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20603440  }} </ref><ref name="pmid1588366">{{cite journal| author=Jaiyesimi IA, Buzdar AU, Hortobagyi G| title=Inflammatory breast cancer: a review. | journal=J Clin Oncol | year= 1992 | volume= 10 | issue= 6 | pages= 1014-24 | pmid=1588366 | doi=10.1200/JCO.1992.10.6.1014 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1588366  }} </ref><ref name="pmid17126205">{{cite journal| author=Indelicato DJ, Grobmyer SR, Newlin H, Morris CG, Haigh LS, Copeland EM et al.| title=Delayed breast cellulitis: an evolving complication of breast conservation. | journal=Int J Radiat Oncol Biol Phys | year= 2006 | volume= 66 | issue= 5 | pages= 1339-46 | pmid=17126205 | doi=10.1016/j.ijrobp.2006.07.1388 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17126205  }} </ref><ref name="pmid21855258">{{cite journal| author=Belleflamme M, Penaloza A, Thoma M, Hainaut P, Thys F| title=Mondor disease: a case report in ED. | journal=Am J Emerg Med | year= 2012 | volume= 30 | issue= 7 | pages= 1325.e1-3 | pmid=21855258 | doi=10.1016/j.ajem.2011.06.031 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21855258  }} </ref><ref name="pmid11566698">{{cite journal| author=Shetty MK, Watson AB| title=Mondor's disease of the breast: sonographic and mammographic findings. | journal=AJR Am J Roentgenol | year= 2001 | volume= 177 | issue= 4 | pages= 893-6 | pmid=11566698 | doi=10.2214/ajr.177.4.1770893 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11566698  }} </ref><ref name="pmid23959419">{{cite journal| author=Kadioglu H, Yildiz S, Ersoy YE, Yücel S, Müslümanoğlu M| title=An unusual case caused by a common reason: Mondor's disease by oral contraceptives. | journal=Int J Surg Case Rep | year= 2013 | volume= 4 | issue= 10 | pages= 855-7 | pmid=23959419 | doi=10.1016/j.ijscr.2013.07.026 | pmc=3785854 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23959419  }} </ref>
Fibroadenoma must be differentiated from other diseases that cause [[breast pain]] and [[swelling]] as shown below:<ref name="pmid16713771">{{cite journal| author=Greydanus DE, Matytsina L, Gains M| title=Breast disorders in children and adolescents. | journal=Prim Care | year= 2006 | volume= 33 | issue= 2 | pages= 455-502 | pmid=16713771 | doi=10.1016/j.pop.2006.02.002 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16713771  }} </ref><ref name="pmid23450563">{{cite journal| author=Jahanfar S, Ng CJ, Teng CL| title=Antibiotics for mastitis in breastfeeding women. | journal=Cochrane Database Syst Rev | year= 2013 | volume=  | issue= 2 | pages= CD005458 | pmid=23450563 | doi=10.1002/14651858.CD005458.pub3 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23450563  }} </ref> <ref name="pmid24791941">{{cite journal| author=Lam E, Chan T, Wiseman SM| title=Breast abscess: evidence based management recommendations. | journal=Expert Rev Anti Infect Ther | year= 2014 | volume= 12 | issue= 7 | pages= 753-62 | pmid=24791941 | doi=10.1586/14787210.2014.913982 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24791941  }} </ref><ref name="pmid11250736">{{cite journal| author=Kleer CG, van Golen KL, Merajver SD| title=Molecular biology of breast cancer metastasis. Inflammatory breast cancer: clinical syndrome and molecular determinants. | journal=Breast Cancer Res | year= 2000 | volume= 2 | issue= 6 | pages= 423-9 | pmid=11250736 | doi=10.1186/bcr89 | pmc=138665 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11250736  }} </ref><ref name="pmid20603440">{{cite journal| author=Dawood S, Merajver SD, Viens P, Vermeulen PB, Swain SM, Buchholz TA et al.| title=International expert panel on inflammatory breast cancer: consensus statement for standardized diagnosis and treatment. | journal=Ann Oncol | year= 2011 | volume= 22 | issue= 3 | pages= 515-23 | pmid=20603440 | doi=10.1093/annonc/mdq345 | pmc=3105293 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20603440  }} </ref><ref name="pmid1588366">{{cite journal| author=Jaiyesimi IA, Buzdar AU, Hortobagyi G| title=Inflammatory breast cancer: a review. | journal=J Clin Oncol | year= 1992 | volume= 10 | issue= 6 | pages= 1014-24 | pmid=1588366 | doi=10.1200/JCO.1992.10.6.1014 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1588366  }} </ref><ref name="pmid17126205">{{cite journal| author=Indelicato DJ, Grobmyer SR, Newlin H, Morris CG, Haigh LS, Copeland EM et al.| title=Delayed breast cellulitis: an evolving complication of breast conservation. | journal=Int J Radiat Oncol Biol Phys | year= 2006 | volume= 66 | issue= 5 | pages= 1339-46 | pmid=17126205 | doi=10.1016/j.ijrobp.2006.07.1388 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17126205  }} </ref><ref name="pmid21855258">{{cite journal| author=Belleflamme M, Penaloza A, Thoma M, Hainaut P, Thys F| title=Mondor disease: a case report in ED. | journal=Am J Emerg Med | year= 2012 | volume= 30 | issue= 7 | pages= 1325.e1-3 | pmid=21855258 | doi=10.1016/j.ajem.2011.06.031 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21855258  }} </ref><ref name="pmid11566698">{{cite journal| author=Shetty MK, Watson AB| title=Mondor's disease of the breast: sonographic and mammographic findings. | journal=AJR Am J Roentgenol | year= 2001 | volume= 177 | issue= 4 | pages= 893-6 | pmid=11566698 | doi=10.2214/ajr.177.4.1770893 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11566698  }} </ref><ref name="pmid23959419">{{cite journal| author=Kadioglu H, Yildiz S, Ersoy YE, Yücel S, Müslümanoğlu M| title=An unusual case caused by a common reason: Mondor's disease by oral contraceptives. | journal=Int J Surg Case Rep | year= 2013 | volume= 4 | issue= 10 | pages= 855-7 | pmid=23959419 | doi=10.1016/j.ijscr.2013.07.026 | pmc=3785854 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23959419  }} </ref>


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Revision as of 18:30, 8 March 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Fibroadenoma must be differentiated from other diseases that cause a similar clinical presentation, such as phyllodes tumor, hamartoma, and adenomyoepithelioma.>[1][2]

Differentiating Fibroadenoma from other Diseases

Fibroadenoma must be differentiated from other diseases that cause breast pain and swelling as shown below:[3][4] [5][6][7][8][9][10][11][12]

Diseases Laboratory Findings Physical Examination History and Symptoms Other Findings
Breast milk culture Biopsy Breast tenderness Skin induration Cordlike vein appearance History of trauma Nipple retraction Nipple discharge Erythema Fever Warmth Lymphadenopathy Itching
Breast abscess + for bacteria
Mastitis + for bacteria
Inflammatory breast cancer *Peau d' orange appearance of the skin

*Metastasis is common.

Galactocele It is differentiated from other masses by US.
Plugged duct
Mondor's syndrome Retracted breast skin and elevation of the skin may be observed.
Cellulitis
Fibroadenoma *Peau d' orange skin apperance.

*Enlarged veins on the skin


  • Fibroadenoma must be differentiated from other diseases that cause a similar clinical presentation, such as:[1][2]
  • Phyllodes tumor
  • Fibrocystic breast changes
  • Hamartoma
  • Papillary carcinoma
  • Pseudoangiomatous stromal hyperplasia
  • Adenomyoepithelioma

References

  1. 1.0 1.1 Fibroadenoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Fibroadenoma Accessed on January, 29 2016
  2. 2.0 2.1 Breast-nonmalignant-Fibroadenoma. PathologyOutlines (2015) http://www.pathologyoutlines.com/topic/breastfibroadenoma.html Accessed on January, 29 2016
  3. Greydanus DE, Matytsina L, Gains M (2006). "Breast disorders in children and adolescents". Prim Care. 33 (2): 455–502. doi:10.1016/j.pop.2006.02.002. PMID 16713771.
  4. Jahanfar S, Ng CJ, Teng CL (2013). "Antibiotics for mastitis in breastfeeding women". Cochrane Database Syst Rev (2): CD005458. doi:10.1002/14651858.CD005458.pub3. PMID 23450563.
  5. Lam E, Chan T, Wiseman SM (2014). "Breast abscess: evidence based management recommendations". Expert Rev Anti Infect Ther. 12 (7): 753–62. doi:10.1586/14787210.2014.913982. PMID 24791941.
  6. Kleer CG, van Golen KL, Merajver SD (2000). "Molecular biology of breast cancer metastasis. Inflammatory breast cancer: clinical syndrome and molecular determinants". Breast Cancer Res. 2 (6): 423–9. doi:10.1186/bcr89. PMC 138665. PMID 11250736.
  7. Dawood S, Merajver SD, Viens P, Vermeulen PB, Swain SM, Buchholz TA; et al. (2011). "International expert panel on inflammatory breast cancer: consensus statement for standardized diagnosis and treatment". Ann Oncol. 22 (3): 515–23. doi:10.1093/annonc/mdq345. PMC 3105293. PMID 20603440.
  8. Jaiyesimi IA, Buzdar AU, Hortobagyi G (1992). "Inflammatory breast cancer: a review". J Clin Oncol. 10 (6): 1014–24. doi:10.1200/JCO.1992.10.6.1014. PMID 1588366.
  9. Indelicato DJ, Grobmyer SR, Newlin H, Morris CG, Haigh LS, Copeland EM; et al. (2006). "Delayed breast cellulitis: an evolving complication of breast conservation". Int J Radiat Oncol Biol Phys. 66 (5): 1339–46. doi:10.1016/j.ijrobp.2006.07.1388. PMID 17126205.
  10. Belleflamme M, Penaloza A, Thoma M, Hainaut P, Thys F (2012). "Mondor disease: a case report in ED". Am J Emerg Med. 30 (7): 1325.e1–3. doi:10.1016/j.ajem.2011.06.031. PMID 21855258.
  11. Shetty MK, Watson AB (2001). "Mondor's disease of the breast: sonographic and mammographic findings". AJR Am J Roentgenol. 177 (4): 893–6. doi:10.2214/ajr.177.4.1770893. PMID 11566698.
  12. Kadioglu H, Yildiz S, Ersoy YE, Yücel S, Müslümanoğlu M (2013). "An unusual case caused by a common reason: Mondor's disease by oral contraceptives". Int J Surg Case Rep. 4 (10): 855–7. doi:10.1016/j.ijscr.2013.07.026. PMC 3785854. PMID 23959419.

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