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{{Familial adenomatous polyposis}}
{{Familial adenomatous polyposis}}


{{CMG}} {{AE}} {{MJK}}
{{CMG}} {{AE}} {{SSH}}, {{MJK}}


==Overview==
==Overview==
Laboratory findings that may present with familial adenomatous polyposis include [[anemia]] due to [[melena]] and abnormal [[liver function tests]] due to colon cancer metastasis.
Laboratory findings that may present with familial adenomatous polyposis include [[anemia]] due to [[gastrointestinal bleeding]] and abnormal [[liver function tests]] due to [[Colorectal cancer|colon cancer]] metastasis.  
==Laboratory Findings==
==Laboratory Findings==
Common laboratory findings that may present with familial adenomatous polyposis are:
Common laboratory findings that may present with familial adenomatous polyposis are:<ref name="pmid11446392">{{cite journal |vauthors=Beech D, Pontius A, Muni N, Long WP |title=Familial adenomatous polyposis: a case report and review of the literature |journal=J Natl Med Assoc |volume=93 |issue=6 |pages=208–13 |year=2001 |pmid=11446392 |pmc=2594024 |doi= |url=}}</ref><ref name="pmid20301519">{{cite journal |vauthors=Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, Jasperson KW, Patel SG, Ahnen DJ |title=APC-Associated Polyposis Conditions. |journal= |volume= |issue= |pages= |year= |pmid=20301519 |doi= |url=}}</ref><ref name="HalfBercovich2009">{{cite journal|last1=Half|first1=Elizabeth|last2=Bercovich|first2=Dani|last3=Rozen|first3=Paul|title=Familial adenomatous polyposis|journal=Orphanet Journal of Rare Diseases|volume=4|issue=1|year=2009|pages=22|issn=1750-1172|doi=10.1186/1750-1172-4-22}}</ref>
 
*'''[[Complete blood count]]:'''
*[[Anemia]] due to [[melena]]
**Low [[hemoglobin]] due to [[gastrointestinal bleeding]] (normal - 12.1 to 15.1 g/dl for women and 13.8 to 17.2 g/dl for men)
*Elevated [[liver function tests|liver function]] due to colon cancer [[metastasis]]
**Elevated [[Platelet|platelet count]] (normal - 150,000 to 450,000 mcL)
*[[Genetic testing]] is helpful to diagnose familial adenomatous polyposis in 95% of the patients
*[[Liver function tests|'''Liver function test''']] :
**The liver function tests may be deranged due to colon cancer [[metastasis]]. The findings may include:
***High [[Aspartate transaminase|aspartate aminotransferase]] ([[Aspartate transaminase|AST]]) (normal -  8 to 48 U/L)
***High [[Alanine transaminase|alanine aminotransferase]] ([[Alanine transaminase|ALT]]) (normal -  7 to 55 units per liter U/L)


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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Latest revision as of 21:43, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2], Mohamad Alkateb, MBBCh [3]

Overview

Laboratory findings that may present with familial adenomatous polyposis include anemia due to gastrointestinal bleeding and abnormal liver function tests due to colon cancer metastasis.

Laboratory Findings

Common laboratory findings that may present with familial adenomatous polyposis are:[1][2][3]

References

  1. Beech D, Pontius A, Muni N, Long WP (2001). "Familial adenomatous polyposis: a case report and review of the literature". J Natl Med Assoc. 93 (6): 208–13. PMC 2594024. PMID 11446392.
  2. Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean L, Stephens K, Amemiya A, Jasperson KW, Patel SG, Ahnen DJ. "APC-Associated Polyposis Conditions". PMID 20301519. Vancouver style error: initials (help)
  3. Half, Elizabeth; Bercovich, Dani; Rozen, Paul (2009). "Familial adenomatous polyposis". Orphanet Journal of Rare Diseases. 4 (1): 22. doi:10.1186/1750-1172-4-22. ISSN 1750-1172.

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