FKBP1B: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Bot: HTTP→HTTPS)
imported>PeaBrainC
(Made reference to potential role in CPVT)
 
Line 1: Line 1:
{{Infobox_gene}}
{{Infobox_gene}}
'''Peptidyl-prolyl cis-trans isomerase FKBP1B''' is an [[enzyme]] that in humans is encoded by the ''FKBP1B'' [[gene]].<ref name="pmid7513996">{{cite journal |vauthors=Arakawa H, Nagase H, Hayashi N, Fujiwara T, Ogawa M, Shin S, Nakamura Y | title = Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts | journal = Biochem Biophys Res Commun | volume = 200 | issue = 2 | pages = 836–43 |date=Jun 1994 | pmid = 7513996 | pmc =  | doi =10.1006/bbrc.1994.1527 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FKBP1B FK506 binding protein 1B, 12.6 kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2281| accessdate = }}</ref>
'''Peptidyl-prolyl cis-trans isomerase FKBP1B''' is an [[enzyme]] that in humans is encoded by the ''FKBP1B'' [[gene]].<ref name="pmid7513996">{{cite journal | vauthors = Arakawa H, Nagase H, Hayashi N, Fujiwara T, Ogawa M, Shin S, Nakamura Y | title = Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts | journal = Biochemical and Biophysical Research Communications | volume = 200 | issue = 2 | pages = 836–43 | date = April 1994 | pmid = 7513996 | pmc =  | doi = 10.1006/bbrc.1994.1527 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FKBP1B FK506 binding protein 1B, 12.6 kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2281| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 ([[tacrolimus]]) and rapamycin ([[sirolimus]]). It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.<ref name="entrez" />
}}


==References==
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 ([[tacrolimus]]) and rapamycin ([[sirolimus]]). It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in [[Muscle contraction|excitation-contraction coupling]] in [[cardiac muscle]]. There are two alternatively spliced transcript variants of this gene encoding different isoforms.<ref name="entrez" />
 
== Clinical significance ==
Defective interaction between FKB1B and the [[ryanodine receptor]] is thought to be a potential mechanism underlying the [[Heart arrhythmia|arrhythmias]] seen in those with the genetic condition [[catecholaminergic polymorphic ventricular tachycardia]]. <ref>{{Cite journal|last=Venetucci|first=Luigi|last2=Denegri|first2=Marco|last3=Napolitano|first3=Carlo|last4=Priori|first4=Silvia G.|date=October 2012|title=Inherited calcium channelopathies in the pathophysiology of arrhythmias|url=https://www.ncbi.nlm.nih.gov/pubmed/22733215|journal=Nature Reviews. Cardiology|volume=9|issue=10|pages=561–575|doi=10.1038/nrcardio.2012.93|issn=1759-5010|pmid=22733215}}</ref>
 
== References ==
{{Reflist}}
{{Reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Schiene-Fischer C, Yu C | title = Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases | journal = FEBS Letters | volume = 495 | issue = 1-2 | pages = 1–6 | date = April 2001 | pmid = 11322937 | doi = 10.1016/S0014-5793(01)02326-2 }}
| citations =
* {{cite journal | vauthors = Lam E, Martin MM, Timerman AP, Sabers C, Fleischer S, Lukas T, Abraham RT, O'Keefe SJ, O'Neill EA, Wiederrecht GJ | title = A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor | journal = The Journal of Biological Chemistry | volume = 270 | issue = 44 | pages = 26511–22 | date = November 1995 | pmid = 7592869 | doi = 10.1074/jbc.270.44.26511 }}
*{{cite journal |vauthors=Schiene-Fischer C, Yu C |title=Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases. |journal=FEBS Lett. |volume=495 |issue= 1-2 |pages= 1–6 |year= 2001 |pmid= 11322937 |doi=10.1016/S0014-5793(01)02326-2 }}
* {{cite journal | vauthors = Noguchi N, Takasawa S, Nata K, Tohgo A, Kato I, Ikehata F, Yonekura H, Okamoto H | title = Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes | journal = The Journal of Biological Chemistry | volume = 272 | issue = 6 | pages = 3133–6 | date = February 1997 | pmid = 9013543 | doi = 10.1074/jbc.272.6.3133 }}
*{{cite journal |vauthors=Lam E, Martin MM, Timerman AP |title=A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26511–22 |year= 1995 |pmid= 7592869 |doi=10.1074/jbc.270.44.26511 |display-authors=etal}}
* {{cite journal | vauthors = Deivanayagam CC, Carson M, Thotakura A, Narayana SV, Chodavarapu RS | title = Structure of FKBP12.6 in complex with rapamycin | journal = Acta Crystallographica D | volume = 56 | issue = Pt 3 | pages = 266–71 | date = March 2000 | pmid = 10713512 | doi = 10.1107/S0907444999016571 }}
*{{cite journal |vauthors=Noguchi N, Takasawa S, Nata K |title=Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes. |journal=J. Biol. Chem. |volume=272 |issue= 6 |pages= 3133–6 |year= 1997 |pmid= 9013543 |doi=10.1074/jbc.272.6.3133 |display-authors=etal}}
* {{cite journal | vauthors = Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR | title = PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts | journal = Cell | volume = 101 | issue = 4 | pages = 365–76 | date = May 2000 | pmid = 10830164 | doi = 10.1016/S0092-8674(00)80847-8 }}
*{{cite journal |vauthors=Deivanayagam CC, Carson M, Thotakura A |title=Structure of FKBP12.6 in complex with rapamycin. |journal=Acta Crystallogr. D |volume=56 |issue= Pt 3 |pages= 266–71 |year= 2000 |pmid= 10713512 |doi=10.1107/S0907444999016571 |display-authors=etal}}
* {{cite journal | vauthors = Jeyakumar LH, Ballester L, Cheng DS, McIntyre JO, Chang P, Olivey HE, Rollins-Smith L, Barnett JV, Murray K, Xin HB, Fleischer S | title = FKBP binding characteristics of cardiac microsomes from diverse vertebrates | journal = Biochemical and Biophysical Research Communications | volume = 281 | issue = 4 | pages = 979–86 | date = March 2001 | pmid = 11237759 | doi = 10.1006/bbrc.2001.4444 }}
*{{cite journal |vauthors=Marx SO, Reiken S, Hisamatsu Y |title=PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. |journal=Cell |volume=101 |issue= 4 |pages= 365–76 |year= 2000 |pmid= 10830164 |doi=10.1016/S0092-8674(00)80847-8 |display-authors=etal}}
* {{cite journal | vauthors = George CH, Sorathia R, Bertrand BM, Lai FA | title = In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6 | journal = The Biochemical Journal | volume = 370 | issue = Pt 2 | pages = 579–89 | date = March 2003 | pmid = 12443530 | pmc = 1223191 | doi = 10.1042/BJ20021433 }}
*{{cite journal |vauthors=Jeyakumar LH, Ballester L, Cheng DS |title=FKBP binding characteristics of cardiac microsomes from diverse vertebrates. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 4 |pages= 979–86 |year= 2001 |pmid= 11237759 |doi= 10.1006/bbrc.2001.4444 |display-authors=etal}}
* {{cite journal | vauthors = Masumiya H, Wang R, Zhang J, Xiao B, Chen SR | title = Localization of the 12.6-kDa FK506-binding protein (FKBP12.6) binding site to the NH2-terminal domain of the cardiac Ca2+ release channel (ryanodine receptor) | journal = The Journal of Biological Chemistry | volume = 278 | issue = 6 | pages = 3786–92 | date = February 2003 | pmid = 12446682 | doi = 10.1074/jbc.M210962200 }}
*{{cite journal |vauthors=George CH, Sorathia R, Bertrand BM, Lai FA |title=In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6. |journal=Biochem. J. |volume=370 |issue= Pt 2 |pages= 579–89 |year= 2003 |pmid= 12443530 |doi= 10.1042/BJ20021433 | pmc=1223191 }}
* {{cite journal | vauthors = Tiso N, Salamon M, Bagattin A, Danieli GA, Argenton F, Bortolussi M | title = The binding of the RyR2 calcium channel to its gating protein FKBP12.6 is oppositely affected by ARVD2 and VTSIP mutations | journal = Biochemical and Biophysical Research Communications | volume = 299 | issue = 4 | pages = 594–8 | date = December 2002 | pmid = 12459180 | doi = 10.1016/S0006-291X(02)02689-X }}
*{{cite journal |vauthors=Masumiya H, Wang R, Zhang J |title=Localization of the 12.6-kDa FK506-binding protein (FKBP12.6) binding site to the NH2-terminal domain of the cardiac Ca2+ release channel (ryanodine receptor). |journal=J. Biol. Chem. |volume=278 |issue= 6 |pages= 3786–92 |year= 2003 |pmid= 12446682 |doi= 10.1074/jbc.M210962200 |display-authors=etal}}
* {{cite journal | vauthors = Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 26 | pages = 16899–903 | date = December 2002 | pmid = 12477932 | pmc = 139241 | doi = 10.1073/pnas.242603899 }}
*{{cite journal |vauthors=Tiso N, Salamon M, Bagattin A |title=The binding of the RyR2 calcium channel to its gating protein FKBP12.6 is oppositely affected by ARVD2 and VTSIP mutations. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 4 |pages= 594–8 |year= 2003 |pmid= 12459180 |doi=10.1016/S0006-291X(02)02689-X |display-authors=etal}}
* {{cite journal | vauthors = George CH, Higgs GV, Mackrill JJ, Lai FA | title = Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 31 | pages = 28856–64 | date = August 2003 | pmid = 12754204 | doi = 10.1074/jbc.M212440200 }}
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
* {{cite journal | vauthors = Nishanian TG, Waldman T | title = Interaction of the BMPR-IA tumor suppressor with a developmentally relevant splicing factor | journal = Biochemical and Biophysical Research Communications | volume = 323 | issue = 1 | pages = 91–7 | date = October 2004 | pmid = 15351706 | doi = 10.1016/j.bbrc.2004.08.060 }}
*{{cite journal  |vauthors=George CH, Higgs GV, Mackrill JJ, Lai FA |title=Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28856–64 |year= 2003 |pmid= 12754204 |doi= 10.1074/jbc.M212440200 }}
* {{cite journal | vauthors = Maalej A, Mbarki F, Rebai A, Karray F, Jouida J, Abid M, Ayadi H | title = Evidence of association between FKBP1B and thyroid autoimmune disorders in a large Tunisian family | journal = Autoimmunity | volume = 37 | issue = 3 | pages = 237–9 | date = May 2004 | pmid = 15497458 | doi = 10.1080/08916930410001702478 }}
*{{cite journal  |vauthors=Nishanian TG, Waldman T |title=Interaction of the BMPR-IA tumor suppressor with a developmentally relevant splicing factor. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 1 |pages= 91–7 |year= 2004 |pmid= 15351706 |doi= 10.1016/j.bbrc.2004.08.060 }}
* {{cite journal | vauthors = Zissimopoulos S, Lai FA | title = Interaction of FKBP12.6 with the cardiac ryanodine receptor C-terminal domain | journal = The Journal of Biological Chemistry | volume = 280 | issue = 7 | pages = 5475–85 | date = February 2005 | pmid = 15591045 | doi = 10.1074/jbc.M412954200 }}
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
* {{cite journal | vauthors = Aizawa Y, Ueda K, Komura S, Washizuka T, Chinushi M, Inagaki N, Matsumoto Y, Hayashi T, Takahashi M, Nakano N, Yasunami M, Kimura A, Hiraoka M, Aizawa Y | title = A novel mutation in FKBP12.6 binding region of the human cardiac ryanodine receptor gene (R2401H) in a Japanese patient with catecholaminergic polymorphic ventricular tachycardia | journal = International Journal of Cardiology | volume = 99 | issue = 2 | pages = 343–5 | date = March 2005 | pmid = 15749201 | doi = 10.1016/j.ijcard.2003.11.050 }}
*{{cite journal |vauthors=Maalej A, Mbarki F, Rebai A |title=Evidence of association between FKBP1B and thyroid autoimmune disorders in a large Tunisian family. |journal=Autoimmunity |volume=37 |issue= 3 |pages= 237–9 |year= 2005 |pmid= 15497458 |doi=10.1080/08916930410001702478  |display-authors=etal}}
* {{cite journal | vauthors = Wehrens XH, Lehnart SE, Reiken S, van der Nagel R, Morales R, Sun J, Cheng Z, Deng SX, de Windt LJ, Landry DW, Marks AR | title = Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 27 | pages = 9607–12 | date = July 2005 | pmid = 15972811 | pmc = 1172237 | doi = 10.1073/pnas.0500353102 }}
*{{cite journal |vauthors=Zissimopoulos S, Lai FA |title=Interaction of FKBP12.6 with the cardiac ryanodine receptor C-terminal domain. |journal=J. Biol. Chem. |volume=280 |issue= 7 |pages= 5475–85 |year= 2005 |pmid= 15591045 |doi= 10.1074/jbc.M412954200 }}
*{{cite journal |vauthors=Aizawa Y, Ueda K, Komura S |title=A novel mutation in FKBP12.6 binding region of the human cardiac ryanodine receptor gene (R2401H) in a Japanese patient with catecholaminergic polymorphic ventricular tachycardia. |journal=Int. J. Cardiol. |volume=99 |issue= 2 |pages= 343–5 |year= 2005 |pmid= 15749201 |doi= 10.1016/j.ijcard.2003.11.050 |display-authors=etal}}
*{{cite journal |vauthors=Wehrens XH, Lehnart SE, Reiken S |title=Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 27 |pages= 9607–12 |year= 2005 |pmid= 15972811 |doi= 10.1073/pnas.0500353102  | pmc=1172237 |display-authors=etal}}
*{{cite journal |vauthors=Won J, Kim M, Yi YW |title=A magnetic nanoprobe technology for detecting molecular interactions in live cells. |journal=Science |volume=309 |issue= 5731 |pages= 121–5 |year= 2005 |pmid= 15994554 |doi= 10.1126/science.1112869 |display-authors=etal}}{{Retracted paper}}
}}
{{refend}}
{{refend}}


Line 40: Line 36:
{{Enzymes}}
{{Enzymes}}
{{Portal bar|Molecular and Cellular Biology|border=no}}
{{Portal bar|Molecular and Cellular Biology|border=no}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


[[Category:EC 5.2.1]]
[[Category:EC 5.2.1]]

Latest revision as of 17:46, 18 November 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Peptidyl-prolyl cis-trans isomerase FKBP1B is an enzyme that in humans is encoded by the FKBP1B gene.[1][2]

Function

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus). It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.[2]

Clinical significance

Defective interaction between FKB1B and the ryanodine receptor is thought to be a potential mechanism underlying the arrhythmias seen in those with the genetic condition catecholaminergic polymorphic ventricular tachycardia. [3]

References

  1. ↑ Arakawa H, Nagase H, Hayashi N, Fujiwara T, Ogawa M, Shin S, Nakamura Y (April 1994). "Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts". Biochemical and Biophysical Research Communications. 200 (2): 836–43. doi:10.1006/bbrc.1994.1527. PMID 7513996.
  2. ↑ 2.0 2.1 "Entrez Gene: FKBP1B FK506 binding protein 1B, 12.6 kDa".
  3. ↑ Venetucci, Luigi; Denegri, Marco; Napolitano, Carlo; Priori, Silvia G. (October 2012). "Inherited calcium channelopathies in the pathophysiology of arrhythmias". Nature Reviews. Cardiology. 9 (10): 561–575. doi:10.1038/nrcardio.2012.93. ISSN 1759-5010. PMID 22733215.

Further reading

  • Schiene-Fischer C, Yu C (April 2001). "Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases". FEBS Letters. 495 (1–2): 1–6. doi:10.1016/S0014-5793(01)02326-2. PMID 11322937.
  • Lam E, Martin MM, Timerman AP, Sabers C, Fleischer S, Lukas T, Abraham RT, O'Keefe SJ, O'Neill EA, Wiederrecht GJ (November 1995). "A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor". The Journal of Biological Chemistry. 270 (44): 26511–22. doi:10.1074/jbc.270.44.26511. PMID 7592869.
  • Noguchi N, Takasawa S, Nata K, Tohgo A, Kato I, Ikehata F, Yonekura H, Okamoto H (February 1997). "Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes". The Journal of Biological Chemistry. 272 (6): 3133–6. doi:10.1074/jbc.272.6.3133. PMID 9013543.
  • Deivanayagam CC, Carson M, Thotakura A, Narayana SV, Chodavarapu RS (March 2000). "Structure of FKBP12.6 in complex with rapamycin". Acta Crystallographica D. 56 (Pt 3): 266–71. doi:10.1107/S0907444999016571. PMID 10713512.
  • Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell. 101 (4): 365–76. doi:10.1016/S0092-8674(00)80847-8. PMID 10830164.
  • Jeyakumar LH, Ballester L, Cheng DS, McIntyre JO, Chang P, Olivey HE, Rollins-Smith L, Barnett JV, Murray K, Xin HB, Fleischer S (March 2001). "FKBP binding characteristics of cardiac microsomes from diverse vertebrates". Biochemical and Biophysical Research Communications. 281 (4): 979–86. doi:10.1006/bbrc.2001.4444. PMID 11237759.
  • George CH, Sorathia R, Bertrand BM, Lai FA (March 2003). "In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6". The Biochemical Journal. 370 (Pt 2): 579–89. doi:10.1042/BJ20021433. PMC 1223191. PMID 12443530.
  • Masumiya H, Wang R, Zhang J, Xiao B, Chen SR (February 2003). "Localization of the 12.6-kDa FK506-binding protein (FKBP12.6) binding site to the NH2-terminal domain of the cardiac Ca2+ release channel (ryanodine receptor)". The Journal of Biological Chemistry. 278 (6): 3786–92. doi:10.1074/jbc.M210962200. PMID 12446682.
  • Tiso N, Salamon M, Bagattin A, Danieli GA, Argenton F, Bortolussi M (December 2002). "The binding of the RyR2 calcium channel to its gating protein FKBP12.6 is oppositely affected by ARVD2 and VTSIP mutations". Biochemical and Biophysical Research Communications. 299 (4): 594–8. doi:10.1016/S0006-291X(02)02689-X. PMID 12459180.
  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • George CH, Higgs GV, Mackrill JJ, Lai FA (August 2003). "Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6". The Journal of Biological Chemistry. 278 (31): 28856–64. doi:10.1074/jbc.M212440200. PMID 12754204.
  • Nishanian TG, Waldman T (October 2004). "Interaction of the BMPR-IA tumor suppressor with a developmentally relevant splicing factor". Biochemical and Biophysical Research Communications. 323 (1): 91–7. doi:10.1016/j.bbrc.2004.08.060. PMID 15351706.
  • Maalej A, Mbarki F, Rebai A, Karray F, Jouida J, Abid M, Ayadi H (May 2004). "Evidence of association between FKBP1B and thyroid autoimmune disorders in a large Tunisian family". Autoimmunity. 37 (3): 237–9. doi:10.1080/08916930410001702478. PMID 15497458.
  • Zissimopoulos S, Lai FA (February 2005). "Interaction of FKBP12.6 with the cardiac ryanodine receptor C-terminal domain". The Journal of Biological Chemistry. 280 (7): 5475–85. doi:10.1074/jbc.M412954200. PMID 15591045.
  • Aizawa Y, Ueda K, Komura S, Washizuka T, Chinushi M, Inagaki N, Matsumoto Y, Hayashi T, Takahashi M, Nakano N, Yasunami M, Kimura A, Hiraoka M, Aizawa Y (March 2005). "A novel mutation in FKBP12.6 binding region of the human cardiac ryanodine receptor gene (R2401H) in a Japanese patient with catecholaminergic polymorphic ventricular tachycardia". International Journal of Cardiology. 99 (2): 343–5. doi:10.1016/j.ijcard.2003.11.050. PMID 15749201.
  • Wehrens XH, Lehnart SE, Reiken S, van der Nagel R, Morales R, Sun J, Cheng Z, Deng SX, de Windt LJ, Landry DW, Marks AR (July 2005). "Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure". Proceedings of the National Academy of Sciences of the United States of America. 102 (27): 9607–12. doi:10.1073/pnas.0500353102. PMC 1172237. PMID 15972811.


Retrieved from "https://www.wikidoc.org/index.php?title=FKBP1B&oldid=1531607"