FABP7: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Fatty acid binding protein 7, brain''' ('''FABP7'''; also '''brain lipid binding protein''', '''BLBP'''), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FABP7 fatty acid binding protein 7, brain| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2173| accessdate = }}</ref>
| update_page = yes
 
| require_manual_inspection = no
== Function ==
| update_protein_box = yes
 
| update_summary = yes
The protein encoded by this gene is a brain fatty acid binding protein. [[Fatty acid binding protein]]s (FABPs) are a [[Protein family|family]] of small, highly conserved, [[cytoplasm]]ic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in [[fatty acid]] uptake, transport, and metabolism.<ref name="entrez"/>
| update_citations = yes
 
}}
FABP7 is expressed, during development, in [[radial glia]] by the activation of [[Notch protein|Notch]] receptors.<!--
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 
{{GNF_Protein_box
--><ref name="pmid15879553">{{cite journal | vauthors = Anthony TE, Mason HA, Gridley T, Fishell G, Heintz N | title = Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells | journal = Genes & Development | volume = 19 | issue = 9 | pages = 1028–33 | date = May 2005 | pmid = 15879553 | pmc = 1091737 | doi = 10.1101/gad.1302105 | url = http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=15879553 }}</ref><!--
| image = PBB_Protein_FABP7_image.jpg
 
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fdq.
--> [[Reelin]] was shown to induce FABP7 expression in neural [[progenitor cell]]s via [[Notch-1]] activation.<!--
| PDB = {{PDB2|1fdq}}, {{PDB2|1fe3}}, {{PDB2|1jjx}}
 
| Name = Fatty acid binding protein 7, brain
--><ref name="pmid18593473">{{cite journal | vauthors = Keilani S, Sugaya K | title = Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1 | journal = BMC Developmental Biology | volume = 8 | issue = 1 | pages = 69 | date = July 2008 | pmid = 18593473 | pmc = 2447831 | doi = 10.1186/1471-213X-8-69 | url = http://www.biomedcentral.com/1471-213X/8/69 }}</ref>
| HGNCid = 3562
 
| Symbol = FABP7
According to one study, FABP7 binds [[docosahexaenoic acid|DHA]] with the highest [[Affinity (pharmacology)|affinity]] among all of the FABPs.<!--
| AltSymbols =; B-FABP; BLBP; DKFZp547J2313; FABPB; MRG
 
| OMIM = 602965
--><ref name="pmid8798739">{{cite journal | vauthors = Xu LZ, Sánchez R, Sali A, Heintz N | title = Ligand specificity of brain lipid-binding protein | journal = The Journal of Biological Chemistry | volume = 271 | issue = 40 | pages = 24711–9 | date = Oct 1996 | pmid = 8798739 | doi = 10.1074/jbc.271.40.24711 | url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=8798739 }}</ref>
| ECnumber = 
 
| Homologene = 37880
[[Image:Fabp7expression.jpg|left|Expression of Fabp7 protein in mouse brains at embryonic day 16 (left) and postnatal day 0 (right). At both stages, Fabp7 is strongly expressed in the ventricular zone and [[radial glia]], where [[neurogenesis]] is prominent.|thumb]]
| MGIid = 101916
 
| GeneAtlas_image1 = PBB_GE_FABP7_205030_at_tn.png
==Role in pathology==
| GeneAtlas_image2 = PBB_GE_FABP7_205029_s_at_tn.png
FABP7 maps onto human chromosome 6q22.31, a schizophrenia [[genetic linkage|linkage]] region corroborated by a meta-analysis.<!--
| GeneAtlas_image3 = PBB_GE_FABP7_216192_at_tn.png
 
| Function = {{GNF_GO|id=GO:0005478 |text = transporter activity}} {{GNF_GO|id=GO:0008289 |text = lipid binding}}
--><ref name="pmid12802786">{{cite journal | vauthors = Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, Williams NM, Schwab SG, Pulver AE, Faraone SV, Brzustowicz LM, Kaufmann CA, Garver DL, Gurling HM, Lindholm E, Coon H, Moises HW, Byerley W, Shaw SH, Mesen A, Sherrington R, O'Neill FA, Walsh D, Kendler KS, Ekelund J, Paunio T, Lönnqvist J, Peltonen L, O'Donovan MC, Owen MJ, Wildenauer DB, Maier W, Nestadt G, Blouin JL, Antonarakis SE, Mowry BJ, Silverman JM, Crowe RR, Cloninger CR, Tsuang MT, Malaspina D, Harkavy-Friedman JM, Svrakic DM, Bassett AS, Holcomb J, Kalsi G, McQuillin A, Brynjolfson J, Sigmundsson T, Petursson H, Jazin E, Zoëga T, Helgason T | title = Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia | journal = American Journal of Human Genetics | volume = 73 | issue = 1 | pages = 34–48 | date = Jul 2003 | pmid = 12802786 | pmc = 1180588 | doi = 10.1086/376549 | url = http://linkinghub.elsevier.com/retrieve/pii/AJHG024834 }}</ref>
| Component =
 
| Process = {{GNF_GO|id=GO:0006631 |text = fatty acid metabolic process}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
As of 2008, two studies have been conducted into FABP7 as a possible risk gene for [[schizophrenia]],<!--
| Orthologs = {{GNF_Ortholog_box
 
    | Hs_EntrezGene = 2173
--><ref name="SZGeneDB">[http://www.schizophreniaforum.org/res/sczgene/geneoverview.asp?geneID=594 Gene Overview of All Published Schizophrenia-Association Studies for FABP7]{{dead link|date=September 2017 |bot=InternetArchiveBot |fix-attempted=yes }} - SZGene database at Schizophrenia Research Forum website.</ref><!--
    | Hs_Ensembl = ENSG00000164434
 
    | Hs_RefseqProtein = NP_001437
--> with one, that tested for only one SNP, showing negative<!--
    | Hs_RefseqmRNA = NM_001446
 
    | Hs_GenLoc_db = 
--><ref name="pmid17893707">{{cite journal | vauthors = Jungerius BJ, Hoogendoorn ML, Bakker SC, Van't Slot R, Bardoel AF, Ophoff RA, Wijmenga C, Kahn RS, Sinke RJ | title = An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia | journal = Molecular Psychiatry | volume = 13 | issue = 11 | pages = 1060–8 | date = Nov 2008 | pmid = 17893707 | doi = 10.1038/sj.mp.4002080 }}</ref><!--
    | Hs_GenLoc_chr = 6
 
    | Hs_GenLoc_start = 123142319
--> and another, with seven SNPs,<!--
    | Hs_GenLoc_end = 123146918
 
    | Hs_Uniprot = O15540
--><ref name="pmid18001149">{{cite journal | vauthors = Watanabe A, Toyota T, Owada Y, Hayashi T, Iwayama Y, Matsumata M, Ishitsuka Y, Nakaya A, Maekawa M, Ohnishi T, Arai R, Sakurai K, Yamada K, Kondo H, Hashimoto K, Osumi N, Yoshikawa T | title = Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype | journal = PLoS Biology | volume = 5 | issue = 11 | pages = e297 | date = Nov 2007 | pmid = 18001149 | pmc = 2071943 | doi = 10.1371/journal.pbio.0050297 | url = http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050297 }}</ref><!--
    | Mm_EntrezGene = 12140
 
    | Mm_Ensembl = ENSMUSG00000019874
--> a positive result. The effect of the gene in the latter study was stronger in males. This study also linked FABP7 variation to weak [[prepulse inhibition]] in mice; deficit in PPI is an [[endophenotype|endophenotypic]] trait observed in schizophrenia patients and their relatives.
    | Mm_RefseqmRNA = XM_975801
 
    | Mm_RefseqProtein = XP_980895
{{Clear}}
    | Mm_GenLoc_db = 
 
    | Mm_GenLoc_chr = 10
== References ==
    | Mm_GenLoc_start = 57473338
{{reflist}}
    | Mm_GenLoc_end = 57476865
 
    | Mm_Uniprot = Q4FJK4
== Further reading ==
  }}
}}
'''Fatty acid binding protein 7, brain''', also known as '''FABP7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FABP7 fatty acid binding protein 7, brain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2173| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =  
| summary_text = The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism.<ref name="entrez">{{cite web | title = Entrez Gene: FABP7 fatty acid binding protein 7, brain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2173| accessdate = }}</ref>
}}
[[Image:Fabp7expression.jpg|left|Expression of Fabp7 protein in mouse brains at embryonic day 16 (left) and postnatal day 0 (right). At both stages, Fabp7 is strongly expressed in the ventricular zone and radial glia, where neurogenesis is prominent.|thumb]]
{{-}}
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Börchers T, Hohoff C, Buhlmann C, Spener F | title = Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation | journal = Prostaglandins, Leukotrienes, and Essential Fatty Acids | volume = 57 | issue = 1 | pages = 77–84 | date = Jul 1997 | pmid = 9250612 | doi = 10.1016/S0952-3278(97)90496-8 }}
| citations =
* {{cite journal | vauthors = Xu LZ, Sánchez R, Sali A, Heintz N | title = Ligand specificity of brain lipid-binding protein | journal = The Journal of Biological Chemistry | volume = 271 | issue = 40 | pages = 24711–9 | date = Oct 1996 | pmid = 8798739 | doi = 10.1074/jbc.271.40.24711 }}
*{{cite journal | author=Börchers T, Hohoff C, Buhlmann C, Spener F |title=Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=57 |issue= 1 |pages= 77-84 |year= 1997 |pmid= 9250612 |doi= }}
* {{cite journal | vauthors = Young JK, Baker JH, Muller T | title = Immunoreactivity for brain-fatty acid binding protein in gomori-positive astrocytes | journal = Glia | volume = 16 | issue = 3 | pages = 218–26 | date = Mar 1996 | pmid = 8833192 | doi = 10.1002/(SICI)1098-1136(199603)16:3<218::AID-GLIA4>3.0.CO;2-Y }}
*{{cite journal | author=Xu LZ, Sánchez R, Sali A, Heintz N |title=Ligand specificity of brain lipid-binding protein. |journal=J. Biol. Chem. |volume=271 |issue= 40 |pages= 24711-9 |year= 1996 |pmid= 8798739 |doi= }}
* {{cite journal | vauthors = Shi YE, Ni J, Xiao G, Liu YE, Fuchs A, Yu G, Su J, Cosgrove JM, Xing L, Zhang M, Li J, Aggarwal BB, Meager A, Gentz R | title = Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG | journal = Cancer Research | volume = 57 | issue = 15 | pages = 3084–91 | date = Aug 1997 | pmid = 9242429 | doi =  }}
*{{cite journal | author=Young JK, Baker JH, Muller T |title=Immunoreactivity for brain-fatty acid binding protein in gomori-positive astrocytes. |journal=Glia |volume=16 |issue= 3 |pages= 218-26 |year= 1997 |pmid= 8833192 |doi= 10.1002/(SICI)1098-1136(199603)16:3&lt;218::AID-GLIA4&gt;3.0.CO;2-Y }}
* {{cite journal | vauthors = Shimizu F, Watanabe TK, Shinomiya H, Nakamura Y, Fujiwara T | title = Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP) | journal = Biochimica et Biophysica Acta | volume = 1354 | issue = 1 | pages = 24–8 | date = Oct 1997 | pmid = 9375786 | doi = 10.1016/S0167-4781(97)00115-2 }}
*{{cite journal | author=Shi YE, Ni J, Xiao G, ''et al.'' |title=Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG. |journal=Cancer Res. |volume=57 |issue= 15 |pages= 3084-91 |year= 1997 |pmid= 9242429 |doi=  }}
* {{cite journal | vauthors = Godbout R, Bisgrove DA, Shkolny D, Day RS | title = Correlation of B-FABP and GFAP expression in malignant glioma | journal = Oncogene | volume = 16 | issue = 15 | pages = 1955–62 | date = Apr 1998 | pmid = 9591779 | doi = 10.1038/sj.onc.1201740 }}
*{{cite journal | author=Shimizu F, Watanabe TK, Shinomiya H, ''et al.'' |title=Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP). |journal=Biochim. Biophys. Acta |volume=1354 |issue= 1 |pages= 24-8 |year= 1997 |pmid= 9375786 |doi= }}
* {{cite journal | vauthors = Pu L, Igbavboa U, Wood WG, Roths JB, Kier AB, Spener F, Schroeder F | title = Expression of fatty acid binding proteins is altered in aged mouse brain | journal = Molecular and Cellular Biochemistry | volume = 198 | issue = 1-2 | pages = 69–78 | date = Aug 1999 | pmid = 10497880 | doi = 10.1023/A:1006946027619 }}
*{{cite journal | author=Godbout R, Bisgrove DA, Shkolny D, Day RS |title=Correlation of B-FABP and GFAP expression in malignant glioma. |journal=Oncogene |volume=16 |issue= 15 |pages= 1955-62 |year= 1998 |pmid= 9591779 |doi= 10.1038/sj.onc.1201740 }}
* {{cite journal | vauthors = Balendiran GK, Schnutgen F, Scapin G, Borchers T, Xhong N, Lim K, Godbout R, Spener F, Sacchettini JC | title = Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein | journal = The Journal of Biological Chemistry | volume = 275 | issue = 35 | pages = 27045–54 | date = Sep 2000 | pmid = 10854433 | doi = 10.1074/jbc.M003001200 }}
*{{cite journal | author=Pu L, Igbavboa U, Wood WG, ''et al.'' |title=Expression of fatty acid binding proteins is altered in aged mouse brain. |journal=Mol. Cell. Biochem. |volume=198 |issue= 1-2 |pages= 69-78 |year= 1999 |pmid= 10497880 |doi= }}
* {{cite journal | vauthors = Rademacher M, Zimmerman AW, Rüterjans H, Veerkamp JH, Lücke C | title = Solution structure of fatty acid-binding protein from human brain | journal = Molecular and Cellular Biochemistry | volume = 239 | issue = 1-2 | pages = 61–8 | date = Oct 2002 | pmid = 12479569 | doi = 10.1023/A:1020566909213 }}
*{{cite journal | author=Balendiran GK, Schnutgen F, Scapin G, ''et al.'' |title=Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27045-54 |year= 2000 |pmid= 10854433 |doi= 10.1074/jbc.M003001200 }}
* {{cite journal | vauthors = Miller SJ, Li H, Rizvi TA, Huang Y, Johansson G, Bowersock J, Sidani A, Vitullo J, Vogel K, Parysek LM, DeClue JE, Ratner N | title = Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis | journal = Molecular and Cellular Biology | volume = 23 | issue = 6 | pages = 2213–24 | date = Mar 2003 | pmid = 12612091 | pmc = 149461 | doi = 10.1128/MCB.23.6.2213-2224.2003 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Sánchez-Font MF, Bosch-Comas A, Gonzàlez-Duarte R, Marfany G | title = Overexpression of FABP7 in Down syndrome fetal brains is associated with PKNOX1 gene-dosage imbalance | journal = Nucleic Acids Research | volume = 31 | issue = 11 | pages = 2769–77 | date = Jun 2003 | pmid = 12771203 | pmc = 156729 | doi = 10.1093/nar/gkg396 }}
*{{cite journal  | author=Rademacher M, Zimmerman AW, Rüterjans H, ''et al.'' |title=Solution structure of fatty acid-binding protein from human brain. |journal=Mol. Cell. Biochem. |volume=239 |issue= 1-2 |pages= 61-8 |year= 2003 |pmid= 12479569 |doi= }}
* {{cite journal | vauthors = Wang M, Liu YE, Goldberg ID, Shi YE | title = Induction of mammary gland differentiation in transgenic mice by the fatty acid-binding protein MRG | journal = The Journal of Biological Chemistry | volume = 278 | issue = 47 | pages = 47319–25 | date = Nov 2003 | pmid = 12975368 | doi = 10.1074/jbc.M308131200 }}
*{{cite journal | author=Miller SJ, Li H, Rizvi TA, ''et al.'' |title=Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis. |journal=Mol. Cell. Biol. |volume=23 |issue= 6 |pages= 2213-24 |year= 2003 |pmid= 12612091 |doi= }}
* {{cite journal | vauthors = Liang Y, Diehn M, Watson N, Bollen AW, Aldape KD, Nicholas MK, [[Kathleen Lamborn|Lamborn KR]], Berger MS, Botstein D, Brown PO, Israel MA | title = Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 16 | pages = 5814–9 | date = Apr 2005 | pmid = 15827123 | pmc = 556127 | doi = 10.1073/pnas.0402870102 }}
*{{cite journal | author=Sánchez-Font MF, Bosch-Comas A, Gonzàlez-Duarte R, Marfany G |title=Overexpression of FABP7 in Down syndrome fetal brains is associated with PKNOX1 gene-dosage imbalance. |journal=Nucleic Acids Res. |volume=31 |issue= 11 |pages= 2769-77 |year= 2003 |pmid= 12771203 |doi= }}
* {{cite journal | vauthors = Liang Y, Bollen AW, Aldape KD, Gupta N | title = Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma | journal = BMC Cancer | volume = 6 | pages = 97 | year = 2006 | pmid = 16623952 | pmc = 1479358 | doi = 10.1186/1471-2407-6-97 }}
*{{cite journal | author=Wang M, Liu YE, Goldberg ID, Shi YE |title=Induction of mammary gland differentiation in transgenic mice by the fatty acid-binding protein MRG. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 47319-25 |year= 2004 |pmid= 12975368 |doi= 10.1074/jbc.M308131200 }}
* {{cite journal | vauthors = Kaloshi G, Mokhtari K, Carpentier C, Taillibert S, Lejeune J, Marie Y, Delattre JY, Godbout R, Sanson M | title = FABP7 expression in glioblastomas: relation to prognosis, invasion and EGFR status | journal = Journal of Neuro-Oncology | volume = 84 | issue = 3 | pages = 245–8 | date = Sep 2007 | pmid = 17415524 | doi = 10.1007/s11060-007-9377-4 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
* {{cite journal | vauthors = Takaoka N, Takayama T, Teratani T, Sugiyama T, Mugiya S, Ozono S | title = Analysis of the regulation of fatty acid binding protein 7 expression in human renal carcinoma cell lines | journal = BMC Molecular Biology | volume = 12 | issue = 1 | pages = 31 | year = 2011 | pmid = 21771320 | pmc = 3162894 | doi = 10.1186/1471-2199-12-31 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Liang Y, Diehn M, Watson N, ''et al.'' |title=Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 16 |pages= 5814-9 |year= 2005 |pmid= 15827123 |doi= 10.1073/pnas.0402870102 }}
*{{cite journal | author=Liang Y, Bollen AW, Aldape KD, Gupta N |title=Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma. |journal=BMC Cancer |volume=6 |issue=  |pages= 97 |year= 2006 |pmid= 16623952 |doi= 10.1186/1471-2407-6-97 }}
*{{cite journal | author=Kaloshi G, Mokhtari K, Carpentier C, ''et al.'' |title=FABP7 expression in glioblastomas: relation to prognosis, invasion and EGFR status. |journal=J. Neurooncol. |volume=84 |issue= 3 |pages= 245-8 |year= 2007 |pmid= 17415524 |doi= 10.1007/s11060-007-9377-4 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
*[http://www.schizophrenia.com/sznews/archives/005778.html Schizophrenia, Startled Response & Fabp7: Future Dietary Changes for At-Risk Mothers?] Schizophrenia Daily News Blog, 2007-11-07
*[http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050320 Gross L (2007) A Candidate Gene for a Biological Marker of Schizophrenia in Mice" ''PLoS Biol'' 5(11)  e320 ] {{doi|10.1371/journal.pbio.0050320}} - a synopsis for the general audience.
 
{{PDB Gallery|geneid=2173}}
{{Carrier proteins}}
 
[[Category:Biology of bipolar disorder]]

Latest revision as of 14:29, 12 August 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene.[1]

Function

The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism.[1]

FABP7 is expressed, during development, in radial glia by the activation of Notch receptors.[2] Reelin was shown to induce FABP7 expression in neural progenitor cells via Notch-1 activation.[3]

According to one study, FABP7 binds DHA with the highest affinity among all of the FABPs.[4]

Expression of Fabp7 protein in mouse brains at embryonic day 16 (left) and postnatal day 0 (right). At both stages, Fabp7 is strongly expressed in the ventricular zone and radial glia, where neurogenesis is prominent.

Role in pathology

FABP7 maps onto human chromosome 6q22.31, a schizophrenia linkage region corroborated by a meta-analysis.[5]

As of 2008, two studies have been conducted into FABP7 as a possible risk gene for schizophrenia,[6] with one, that tested for only one SNP, showing negative[7] and another, with seven SNPs,[8] a positive result. The effect of the gene in the latter study was stronger in males. This study also linked FABP7 variation to weak prepulse inhibition in mice; deficit in PPI is an endophenotypic trait observed in schizophrenia patients and their relatives.

References

  1. ↑ 1.0 1.1 "Entrez Gene: FABP7 fatty acid binding protein 7, brain".
  2. ↑ Anthony TE, Mason HA, Gridley T, Fishell G, Heintz N (May 2005). "Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells". Genes & Development. 19 (9): 1028–33. doi:10.1101/gad.1302105. PMC 1091737. PMID 15879553.
  3. ↑ Keilani S, Sugaya K (July 2008). "Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1". BMC Developmental Biology. 8 (1): 69. doi:10.1186/1471-213X-8-69. PMC 2447831. PMID 18593473.
  4. ↑ Xu LZ, Sánchez R, Sali A, Heintz N (Oct 1996). "Ligand specificity of brain lipid-binding protein". The Journal of Biological Chemistry. 271 (40): 24711–9. doi:10.1074/jbc.271.40.24711. PMID 8798739.
  5. ↑ Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, Williams NM, Schwab SG, Pulver AE, Faraone SV, Brzustowicz LM, Kaufmann CA, Garver DL, Gurling HM, Lindholm E, Coon H, Moises HW, Byerley W, Shaw SH, Mesen A, Sherrington R, O'Neill FA, Walsh D, Kendler KS, Ekelund J, Paunio T, Lönnqvist J, Peltonen L, O'Donovan MC, Owen MJ, Wildenauer DB, Maier W, Nestadt G, Blouin JL, Antonarakis SE, Mowry BJ, Silverman JM, Crowe RR, Cloninger CR, Tsuang MT, Malaspina D, Harkavy-Friedman JM, Svrakic DM, Bassett AS, Holcomb J, Kalsi G, McQuillin A, Brynjolfson J, Sigmundsson T, Petursson H, Jazin E, Zoëga T, Helgason T (Jul 2003). "Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia". American Journal of Human Genetics. 73 (1): 34–48. doi:10.1086/376549. PMC 1180588. PMID 12802786.
  6. ↑ Gene Overview of All Published Schizophrenia-Association Studies for FABP7[permanent dead link] - SZGene database at Schizophrenia Research Forum website.
  7. ↑ Jungerius BJ, Hoogendoorn ML, Bakker SC, Van't Slot R, Bardoel AF, Ophoff RA, Wijmenga C, Kahn RS, Sinke RJ (Nov 2008). "An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia". Molecular Psychiatry. 13 (11): 1060–8. doi:10.1038/sj.mp.4002080. PMID 17893707.
  8. ↑ Watanabe A, Toyota T, Owada Y, Hayashi T, Iwayama Y, Matsumata M, Ishitsuka Y, Nakaya A, Maekawa M, Ohnishi T, Arai R, Sakurai K, Yamada K, Kondo H, Hashimoto K, Osumi N, Yoshikawa T (Nov 2007). "Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype". PLoS Biology. 5 (11): e297. doi:10.1371/journal.pbio.0050297. PMC 2071943. PMID 18001149.

Further reading

External links

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