EIF3B: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Eukaryotic translation initiation factor 3 subunit B''' ('''eIF3b''') is a [[protein]] that in humans is encoded by the ''EIF3B'' [[gene]].<ref name="pmid8995410">{{cite journal | vauthors = Méthot N, Rom E, Olsen H, Sonenberg N | title = The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170 | journal = J. Biol. Chem. | volume = 272 | issue = 2 | pages = 1110–6  | date = February 1997 | pmid = 8995410 | pmc =  | doi = 10.1074/jbc.272.2.1110 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EIF3S9 eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8662| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_EIF3S9_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2nlw.
| PDB = {{PDB2|2nlw}}
| Name = Eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa
| HGNCid = 3280
| Symbol = EIF3S9
| AltSymbols =; EIF3-ETA; EIF3-P110; EIF3-P116; MGC104664; MGC131875; PRT1; eIF3b
| OMIM = 603917
| ECnumber = 
| Homologene = 2780
| MGIid = 106478
| GeneAtlas_image1 = PBB_GE_EIF3S9_211501_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_EIF3S9_203462_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_EIF3S9_208688_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}}
| Component = {{GNF_GO|id=GO:0005852 |text = eukaryotic translation initiation factor 3 complex}}
| Process = {{GNF_GO|id=GO:0006413 |text = translational initiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8662
    | Hs_Ensembl = ENSG00000106263
    | Hs_RefseqProtein = NP_001032360
    | Hs_RefseqmRNA = NM_001037283
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 2361027
    | Hs_GenLoc_end = 2386904
    | Hs_Uniprot = P55884
    | Mm_EntrezGene = 27979
    | Mm_Ensembl = ENSMUSG00000056076
    | Mm_RefseqmRNA = NM_133916
    | Mm_RefseqProtein = NP_598677
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 140671779
    | Mm_GenLoc_end = 140695834
    | Mm_Uniprot = Q8JZQ9
  }}
}}
'''Eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa''', also known as '''EIF3S9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF3S9 eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8662| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
EIF3B has been shown to [[Protein-protein interaction|interact]] with [[P70-S6 Kinase 1]]<ref name=pmid16286006>{{cite journal | vauthors = Holz MK, Ballif BA, Gygi SP, Blenis J | title = mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events | journal = Cell | volume = 123 | issue = 4 | pages = 569–80  | date = November 2005 | pmid = 16286006 | doi = 10.1016/j.cell.2005.10.024 }}</ref> and [[EIF3A]].<ref name=pmid8995410 /><ref name=pmid14519125>{{cite journal | vauthors = Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW | title = Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 | journal = Eur. J. Biochem. | volume = 270 | issue = 20 | pages = 4133–9  | date = October 2003 | pmid = 14519125 | doi = 10.1046/j.1432-1033.2003.03807.x }}</ref><ref name=pmid16541103>{{cite journal | vauthors = Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC | title = mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin | journal = EMBO J. | volume = 25 | issue = 8 | pages = 1659–68 | date = April 2006 | pmid = 16541103 | pmc = 1440840 | doi = 10.1038/sj.emboj.7601047 }}</ref><ref name=pmid9822659>{{cite journal | vauthors = Block KL, Vornlocher HP, Hershey JW | title = Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 | journal = J. Biol. Chem. | volume = 273 | issue = 48 | pages = 31901–8  | date = November 1998 | pmid = 9822659 | doi = 10.1074/jbc.273.48.31901 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== See also ==
{{reflist|2}}
*[[Eukaryotic initiation factor 3|Eukaryotic initiation factor 3 (eIF3)]]
==Further reading==
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kirken RA, Rui H, Evans GA, Farrar WL | title = Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit | journal = J. Biol. Chem. | volume = 268 | issue = 30 | pages = 22765–70 | year = 1993 | pmid = 7693677 | doi =  }}
| citations =
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Kirken RA, Rui H, Evans GA, Farrar WL |title=Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit. |journal=J. Biol. Chem. |volume=268 |issue= 30 |pages= 22765-70 |year= 1993 |pmid= 7693677 |doi=  }}
* {{cite journal | vauthors = Asano K, Kinzy TG, Merrick WC, Hershey JW | title = Conservation and diversity of eukaryotic translation initiation factor eIF3 | journal = J. Biol. Chem. | volume = 272 | issue = 2 | pages = 1101–9 | year = 1997 | pmid = 8995409 | doi = 10.1074/jbc.272.2.1101 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Chaudhuri J, Chakrabarti A, Maitra U | title = Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1 | journal = J. Biol. Chem. | volume = 272 | issue = 49 | pages = 30975–83 | year = 1997 | pmid = 9388245 | doi = 10.1074/jbc.272.49.30975 }}
*{{cite journal | author=Asano K, Kinzy TG, Merrick WC, Hershey JW |title=Conservation and diversity of eukaryotic translation initiation factor eIF3. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1101-9 |year= 1997 |pmid= 8995409 |doi= }}
* {{cite journal | vauthors = Block KL, Vornlocher HP, Hershey JW | title = Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 | journal = J. Biol. Chem. | volume = 273 | issue = 48 | pages = 31901–8 | year = 1998 | pmid = 9822659 | doi = 10.1074/jbc.273.48.31901 }}
*{{cite journal  | author=Méthot N, Rom E, Olsen H, Sonenberg N |title=The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1110-6 |year= 1997 |pmid= 8995410 |doi=  }}
* {{cite journal | vauthors = | title = Toward a complete human genome sequence | journal = Genome Res. | volume = 8 | issue = 11 | pages = 1097–108 | year = 1998 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 }}
*{{cite journal | author=Chaudhuri J, Chakrabarti A, Maitra U |title=Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1. |journal=J. Biol. Chem. |volume=272 |issue= 49 |pages= 30975-83 |year= 1998 |pmid= 9388245 |doi= }}
* {{cite journal | vauthors = Lin L, Holbro T, Alonso G, Gerosa D, Burger MM | title = Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7 | journal = J. Cell. Biochem. | volume = 80 | issue = 4 | pages = 483–90 | year = 2001 | pmid = 11169732 | doi = 10.1002/1097-4644(20010315)80:4<483::AID-JCB1002>3.0.CO;2-B }}
*{{cite journal | author=Block KL, Vornlocher HP, Hershey JW |title=Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3. |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 31901-8 |year= 1998 |pmid= 9822659 |doi= }}
* {{cite journal | vauthors = Asano K, Shalev A, Phan L, Nielsen K, Clayton J, Valásek L, Donahue TF, Hinnebusch AG | title = Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation | journal = EMBO J. | volume = 20 | issue = 9 | pages = 2326–37 | year = 2001 | pmid = 11331597 | pmc = 125443 | doi = 10.1093/emboj/20.9.2326 }}
*{{cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi= }}
* {{cite journal | vauthors = Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW | title = Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 | journal = Eur. J. Biochem. | volume = 270 | issue = 20 | pages = 4133–9 | year = 2003 | pmid = 14519125 | doi = 10.1046/j.1432-1033.2003.03807.x }}
*{{cite journal | author=Lin L, Holbro T, Alonso G, ''et al.'' |title=Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. |journal=J. Cell. Biochem. |volume=80 |issue= 4 |pages= 483-90 |year= 2001 |pmid= 11169732 |doi= }}
* {{cite journal | vauthors = Fraser CS, Lee JY, Mayeur GL, Bushell M, Doudna JA, Hershey JW | title = The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro | journal = J. Biol. Chem. | volume = 279 | issue = 10 | pages = 8946–56 | year = 2004 | pmid = 14688252 | doi = 10.1074/jbc.M312745200 }}
*{{cite journal | author=Asano K, Shalev A, Phan L, ''et al.'' |title=Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2326-37 |year= 2001 |pmid= 11331597 |doi= 10.1093/emboj/20.9.2326 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nat. Biotechnol. | volume = 23 | issue = 1 | pages = 94–101 | year = 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 }}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Mayeur GL, Fraser CS, Peiretti F, ''et al.'' |title=Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3. |journal=Eur. J. Biochem. |volume=270 |issue= 20 |pages= 4133-9 |year= 2003 |pmid= 14519125 |doi= }}
* {{cite journal | vauthors = ElAntak L, Tzakos AG, Locker N, Lukavsky PJ | title = Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit | journal = J. Biol. Chem. | volume = 282 | issue = 11 | pages = 8165–74 | year = 2007 | pmid = 17190833 | doi = 10.1074/jbc.M610860200 }}
*{{cite journal | author=Fraser CS, Lee JY, Mayeur GL, ''et al.'' |title=The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. |journal=J. Biol. Chem. |volume=279 |issue= 10 |pages= 8946-56 |year= 2004 |pmid= 14688252 |doi= 10.1074/jbc.M312745200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=ElAntak L, Tzakos AG, Locker N, Lukavsky PJ |title=Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit. |journal=J. Biol. Chem. |volume=282 |issue= 11 |pages= 8165-74 |year= 2007 |pmid= 17190833 |doi= 10.1074/jbc.M610860200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=8662}}
{{WikiDoc Sources}}
 
{{Initiation factors}}
 
 
{{gene-7-stub}}

Latest revision as of 03:40, 3 January 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Eukaryotic translation initiation factor 3 subunit B (eIF3b) is a protein that in humans is encoded by the EIF3B gene.[1][2]

Interactions

EIF3B has been shown to interact with P70-S6 Kinase 1[3] and EIF3A.[1][4][5][6]

See also

References

  1. ↑ 1.0 1.1 Méthot N, Rom E, Olsen H, Sonenberg N (February 1997). "The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J. Biol. Chem. 272 (2): 1110–6. doi:10.1074/jbc.272.2.1110. PMID 8995410.
  2. ↑ "Entrez Gene: EIF3S9 eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa".
  3. ↑ Holz MK, Ballif BA, Gygi SP, Blenis J (November 2005). "mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events". Cell. 123 (4): 569–80. doi:10.1016/j.cell.2005.10.024. PMID 16286006.
  4. ↑ Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (October 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
  5. ↑ Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC (April 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO J. 25 (8): 1659–68. doi:10.1038/sj.emboj.7601047. PMC 1440840. PMID 16541103.
  6. ↑ Block KL, Vornlocher HP, Hershey JW (November 1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. 273 (48): 31901–8. doi:10.1074/jbc.273.48.31901. PMID 9822659.

Further reading


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