EIF2B1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Translation initiation factor eIF-2B subunit alpha''' is a [[protein]] that in humans is encoded by the ''EIF2B1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1967| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


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== Interactions ==
{{GNF_Protein_box
EIF2B1 has been shown to [[Protein-protein interaction|interact]] with [[EIF2B5]].<ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein–protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref><ref name=pmid10858531>{{cite journal | vauthors = Anthony TG, Fabian JR, Kimball SR, Jefferson LS | title = Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation | journal = Biochim. Biophys. Acta | volume = 1492 | issue = 1 | pages = 56–62 | date = June 2000 | pmid = 10858531 | doi = 10.1016/S0167-4781(00)00062-2 }}</ref>
| image =
| image_source =
| PDB =  
| Name = Eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
| HGNCid = 3257
| Symbol = EIF2B1
| AltSymbols =; EIF-2B; EIF-2Balpha; EIF2B; EIF2BA; MGC117409; MGC125868; MGC125869
| OMIM = 606686
| ECnumber = 
| Homologene = 1080
| MGIid = 2384802
| GeneAtlas_image1 = PBB_GE_EIF2B1_201632_at_tn.png
| Function = {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005851 |text = eukaryotic translation initiation factor 2B complex}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0006413 |text = translational initiation}} {{GNF_GO|id=GO:0009408 |text = response to heat}} {{GNF_GO|id=GO:0009749 |text = response to glucose stimulus}} {{GNF_GO|id=GO:0014003 |text = oligodendrocyte development}} {{GNF_GO|id=GO:0043434 |text = response to peptide hormone stimulus}} {{GNF_GO|id=GO:0044237 |text = cellular metabolic process}} {{GNF_GO|id=GO:0051716 |text = cellular response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1967
    | Hs_Ensembl = ENSG00000111361
    | Hs_RefseqProtein = NP_001405
    | Hs_RefseqmRNA = NM_001414
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 122672256
    | Hs_GenLoc_end = 122684200
    | Hs_Uniprot = Q14232
    | Mm_EntrezGene = 209354
    | Mm_Ensembl = ENSMUSG00000029388
    | Mm_RefseqmRNA = NM_145371
    | Mm_RefseqProtein = NP_663346
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 124831808
    | Mm_GenLoc_end = 124839157
    | Mm_Uniprot = Q3UZR8
  }}
}}
'''Eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa''', also known as '''EIF2B1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1967| accessdate = }}</ref>


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== References ==
{{PBB_Summary
{{reflist}}
| section_title =
| summary_text =
}}


==References==
== Further reading ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hershey JW | title = Translational control in mammalian cells | journal = Annu. Rev. Biochem. | volume = 60 | issue =  | pages = 717–55 | year = 1991 | pmid = 1883206 | doi = 10.1146/annurev.bi.60.070191.003441 }}
| citations =
* {{cite journal | vauthors = Flowers KM, Mellor H, Kimball SR, Jefferson LS | title = Structure and sequence of the gene encoding the alpha-subunit of rat translation initiation factor-2B | journal = Biochim. Biophys. Acta | volume = 1264 | issue = 2 | pages = 163–7 | year = 1996 | pmid = 7495858 | doi = 10.1016/0167-4781(95)00160-i }}
*{{cite journal | author=Hershey JW |title=Translational control in mammalian cells. |journal=Annu. Rev. Biochem. |volume=60 |issue=  |pages= 717-55 |year= 1991 |pmid= 1883206 |doi= 10.1146/annurev.bi.60.070191.003441 }}
* {{cite journal | vauthors = Welsh GI, Miyamoto S, Price NT, Safer B, Proud CG | title = T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3 | journal = J. Biol. Chem. | volume = 271 | issue = 19 | pages = 11410–3 | year = 1996 | pmid = 8626696 | doi = 10.1074/jbc.271.19.11410 }}
*{{cite journal | author=Flowers KM, Mellor H, Kimball SR, Jefferson LS |title=Structure and sequence of the gene encoding the alpha-subunit of rat translation initiation factor-2B. |journal=Biochim. Biophys. Acta |volume=1264 |issue= 2 |pages= 163-7 |year= 1996 |pmid= 7495858 |doi= }}
* {{cite journal | vauthors = Yang W, Hinnebusch AG | title = Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2 | journal = Mol. Cell. Biol. | volume = 16 | issue = 11 | pages = 6603–16 | year = 1996 | pmid = 8887689 | pmc = 231662 | doi =  }}
*{{cite journal | author=Welsh GI, Miyamoto S, Price NT, ''et al.'' |title=T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3. |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11410-3 |year= 1996 |pmid= 8626696 |doi= }}
* {{cite journal | vauthors = Klein U, Ramirez MT, Kobilka BK, von Zastrow M | title = A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B | journal = J. Biol. Chem. | volume = 272 | issue = 31 | pages = 19099–102 | year = 1997 | pmid = 9235896 | doi = 10.1074/jbc.272.31.19099 }}
*{{cite journal | author=Yang W, Hinnebusch AG |title=Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2. |journal=Mol. Cell. Biol. |volume=16 |issue= 11 |pages= 6603-16 |year= 1996 |pmid= 8887689 |doi=  }}
* {{cite journal | vauthors = Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS | title = Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B | journal = J. Biol. Chem. | volume = 273 | issue = 5 | pages = 3039–44 | year = 1998 | pmid = 9446619 | doi = 10.1074/jbc.273.5.3039 }}
*{{cite journal | author=Klein U, Ramirez MT, Kobilka BK, von Zastrow M |title=A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B. |journal=J. Biol. Chem. |volume=272 |issue= 31 |pages= 19099-102 |year= 1997 |pmid= 9235896 |doi= }}
* {{cite journal | vauthors = Gomez E, Pavitt GD | title = Identification of Domains and Residues within the ɛ Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2Bɛ) Required for Guanine Nucleotide Exchange Reveals a Novel Activation Function Promoted by eIF2B Complex Formation | journal = Mol. Cell. Biol. | volume = 20 | issue = 11 | pages = 3965–76 | year = 2000 | pmid = 10805739 | pmc = 85753 | doi = 10.1128/MCB.20.11.3965-3976.2000 }}
*{{cite journal | author=Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS |title=Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B. |journal=J. Biol. Chem. |volume=273 |issue= 5 |pages= 3039-44 |year= 1998 |pmid= 9446619 |doi= }}
* {{cite journal | vauthors = Anthony TG, Fabian JR, Kimball SR, Jefferson LS | title = Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation | journal = Biochim. Biophys. Acta | volume = 1492 | issue = 1 | pages = 56–62 | year = 2000 | pmid = 10858531 | doi = 10.1016/S0167-4781(00)00062-2 }}
*{{cite journal | author=Gomez E, Pavitt GD |title=Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation. |journal=Mol. Cell. Biol. |volume=20 |issue= 11 |pages= 3965-76 |year= 2000 |pmid= 10805739 |doi= }}
* {{cite journal | vauthors = Williams DD, Price NT, Loughlin AJ, Proud CG | title = Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein | journal = J. Biol. Chem. | volume = 276 | issue = 27 | pages = 24697–703 | year = 2001 | pmid = 11323413 | doi = 10.1074/jbc.M011788200 }}
*{{cite journal | author=Anthony TG, Fabian JR, Kimball SR, Jefferson LS |title=Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation. |journal=Biochim. Biophys. Acta |volume=1492 |issue= 1 |pages= 56-62 |year= 2000 |pmid= 10858531 |doi= }}
* {{cite journal | vauthors = van der Knaap MS, Leegwater PA, Könst AA, Visser A, Naidu S, Oudejans CB, Schutgens RB, Pronk JC | title = Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter | journal = Ann. Neurol. | volume = 51 | issue = 2 | pages = 264–70 | year = 2002 | pmid = 11835386 | doi = 10.1002/ana.10112 }}
*{{cite journal | author=Williams DD, Price NT, Loughlin AJ, Proud CG |title=Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 24697-703 |year= 2001 |pmid= 11323413 |doi= 10.1074/jbc.M011788200 }}
* {{cite journal | vauthors = Fogli A, Dionisi-Vici C, Deodato F, Bartuli A, Boespflug-Tanguy O, Bertini E | title = A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation | journal = Neurology | volume = 59 | issue = 12 | pages = 1966–8 | year = 2003 | pmid = 12499492 | doi = 10.1212/01.wnl.0000041666.76863.47 }}
*{{cite journal | author=van der Knaap MS, Leegwater PA, Könst AA, ''et al.'' |title=Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter. |journal=Ann. Neurol. |volume=51 |issue= 2 |pages= 264-70 |year= 2002 |pmid= 11835386 |doi=  }}
* {{cite journal | vauthors = Fogli A, Rodriguez D, Eymard-Pierre E, Bouhour F, Labauge P, Meaney BF, Zeesman S, Kaneski CR, Schiffmann R, Boespflug-Tanguy O | title = Ovarian Failure Related to Eukaryotic Initiation Factor 2B Mutations | journal = Am. J. Hum. Genet. | volume = 72 | issue = 6 | pages = 1544–50 | year = 2003 | pmid = 12707859 | pmc = 1180314 | doi = 10.1086/375404 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = van der Knaap MS, van Berkel CG, Herms J, van Coster R, Baethmann M, Naidu S, Boltshauser E, Willemsen MA, Plecko B, Hoffmann GF, Proud CG, Scheper GC, Pronk JC | title = eIF2B-Related Disorders: Antenatal Onset and Involvement of Multiple Organs | journal = Am. J. Hum. Genet. | volume = 73 | issue = 5 | pages = 1199–207 | year = 2004 | pmid = 14566705 | pmc = 1180499 | doi = 10.1086/379524 }}
*{{cite journal | author=Fogli A, Dionisi-Vici C, Deodato F, ''et al.'' |title=A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation. |journal=Neurology |volume=59 |issue= 12 |pages= 1966-8 |year= 2003 |pmid= 12499492 |doi= }}
* {{cite journal | vauthors = Richardson JP, Mohammad SS, Pavitt GD | title = Mutations Causing Childhood Ataxia with Central Nervous System Hypomyelination Reduce Eukaryotic Initiation Factor 2B Complex Formation and Activity | journal = Mol. Cell. Biol. | volume = 24 | issue = 6 | pages = 2352–63 | year = 2004 | pmid = 14993275 | pmc = 355856 | doi = 10.1128/MCB.24.6.2352-2363.2004 }}
*{{cite journal | author=Fogli A, Rodriguez D, Eymard-Pierre E, ''et al.'' |title=Ovarian failure related to eukaryotic initiation factor 2B mutations. |journal=Am. J. Hum. Genet. |volume=72 |issue= 6 |pages= 1544-50 |year= 2003 |pmid= 12707859 |doi= }}
* {{cite journal | vauthors = Li W, Wang X, Van Der Knaap MS, Proud CG | title = Mutations Linked to Leukoencephalopathy with Vanishing White Matter Impair the Function of the Eukaryotic Initiation Factor 2B Complex in Diverse Ways | journal = Mol. Cell. Biol. | volume = 24 | issue = 8 | pages = 3295–306 | year = 2004 | pmid = 15060152 | pmc = 381664 | doi = 10.1128/MCB.24.8.3295-3306.2004 }}
*{{cite journal | author=van der Knaap MS, van Berkel CG, Herms J, ''et al.'' |title=eIF2B-related disorders: antenatal onset and involvement of multiple organs. |journal=Am. J. Hum. Genet. |volume=73 |issue= 5 |pages= 1199-207 |year= 2004 |pmid= 14566705 |doi= }}
* {{cite journal | vauthors = Van Haren K, van der Voorn JP, Peterson DR, van der Knaap MS, Powers JM | title = The life and death of oligodendrocytes in vanishing white matter disease | journal = J. Neuropathol. Exp. Neurol. | volume = 63 | issue = 6 | pages = 618–30 | year = 2004 | pmid = 15217090 | doi =  }}
*{{cite journal | author=Richardson JP, Mohammad SS, Pavitt GD |title=Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity. |journal=Mol. Cell. Biol. |volume=24 |issue= 6 |pages= 2352-63 |year= 2004 |pmid= 14993275 |doi= }}
* {{cite journal | vauthors = Yin X, Warner DR, Roberts EA, Pisano MM, Greene RM | title = Identification of novel CBP interacting proteins in embryonic orofacial tissue | journal = Biochem. Biophys. Res. Commun. | volume = 329 | issue = 3 | pages = 1010–7 | year = 2005 | pmid = 15752756 | doi = 10.1016/j.bbrc.2005.02.075 }}
*{{cite journal | author=Li W, Wang X, Van Der Knaap MS, Proud CG |title=Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways. |journal=Mol. Cell. Biol. |volume=24 |issue= 8 |pages= 3295-306 |year= 2004 |pmid= 15060152 |doi= }}
*{{cite journal | author=Van Haren K, van der Voorn JP, Peterson DR, ''et al.'' |title=The life and death of oligodendrocytes in vanishing white matter disease. |journal=J. Neuropathol. Exp. Neurol. |volume=63 |issue= 6 |pages= 618-30 |year= 2004 |pmid= 15217090 |doi=  }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Yin X, Warner DR, Roberts EA, ''et al.'' |title=Identification of novel CBP interacting proteins in embryonic orofacial tissue. |journal=Biochem. Biophys. Res. Commun. |volume=329 |issue= 3 |pages= 1010-7 |year= 2005 |pmid= 15752756 |doi= 10.1016/j.bbrc.2005.02.075 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Genetic translation}}
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{{gene-12-stub}}

Latest revision as of 00:23, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Translation initiation factor eIF-2B subunit alpha is a protein that in humans is encoded by the EIF2B1 gene.[1]

Interactions

EIF2B1 has been shown to interact with EIF2B5.[2][3]

References

  1. ↑ "Entrez Gene: EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa".
  2. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  3. ↑ Anthony TG, Fabian JR, Kimball SR, Jefferson LS (June 2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta. 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID 10858531.

Further reading


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