Doxycycline hyclate: Difference between revisions

Revision as of 01:54, 9 January 2014

Doxycycline hyclate
DOXY 100^® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Overdosage
Dosage and Administration
How Supplied
Labels and Packages

For patient information, click here.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]

Overview

US Brand Names

DOXY 100 '^®

FDA Package Insert

Mechanism of Action

Doxycycline is primarily bacteriostatic and thought to exert its antimicrobial effect by the inhibition of protein synthesis. Doxycycline is active against a wide range of gram-positive and gram-negative organisms.^[1]

References

↑ "DOXY 100 (DOXYCYCLINE) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [APP PHARMACEUTICALS, LLC]". Text " accessdate" ignored (help)

[dailymed.nlm.nih.gov-1] "DOXY 100 (DOXYCYCLINE) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [APP PHARMACEUTICALS, LLC]". Text " accessdate" ignored (help)

[1]

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 ==Mechanism of Action==
-As with related tetracycline antibiotics, demeclocycline acts by binding to the [[30S]] and [[50S]] ribosomal subunits, which impairs [[protein synthesis]] by bacteria. It is [[bacteriostatic]] (it impairs bacterial growth, but does not kill bacteria directly).
+Doxycycline is primarily bacteriostatic and thought to exert its antimicrobial effect by the inhibition of protein synthesis.  Doxycycline is active against a wide range of gram-positive and gram-negative organisms.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = DOXY 100 (DOXYCYCLINE) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [APP PHARMACEUTICALS, LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b0894010-39bd-459f-8563-cf83343105ee | publisher =  | date =  | accessdate}}</ref>
-It is not completely understood why demeclocycline impairs the action of [[antidiuretic hormone]], but is thought to block the binding of the hormone from its [[receptor (biochemistry)|receptor]].<ref>{{cite journal |doi=10.1056/NEJM197510302931809 |author=De Troyer A, Demanet JC |title=Correction of antidiuresis by demeclocycline |journal=N Engl J Med |volume=293 |issue=18 |pages=915–8 |year=1975 |pmid=170519}}</ref>
 ==References==