De Quervain's thyroiditis natural history, complications and prognosis
De Quervain's thyroiditis Microchapters |
Differentiating De Quervain's thyroiditis from other Diseases |
---|
Diagnosis |
Treatment |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
De Quervain's thyroiditis develops after a viral prodrome and presents as painful thyroid gland with symptoms of thyrotoxicosis. It further leads to a euthyroid phase and eventually hypothyroid phase before the complete resolution of the disease. Complications include hypothyroidism and rarely, tracheal or esophageal compression.
Natural History
De Quervain's thyroiditis develops after a viral prodrome and presents as painful thyroid gland with symptoms of thyrotoxicosis. It further leads to a euthyroid phase and eventually hypothyroid phase before the complete resolution of the disease.[1][2][3]
1.Prodromal stage
It includes:
- Low-grade fever and viral flu-like symptoms, such as sore throat, myalgia, arthralgia, and malaise.
- High-grade fever and neck pain with a tender and diffuse thyroid gland enlargement follow flu-like symptoms.
1.Hyperthyroid stage
It follows the prodromal stage and includes the symptoms of thyrotoxicosis such as:
- Tachycardia and tremors.
- Irritability and nervousness.
2.Euthyroid stage
Thyrotoxic stage is followed by a 1–3-week period of euthyroid phase.
4.Hypothyroid stage
The transient hypothyroid stage lasts for 6-12 months.
- Rarely, the hypothyroid stage may persist for a longer duration.
Complications
Complications that can develop as a result of de Quervain's thyroiditis are:[1][2][3]
- Hypothyroidism
- Tracheal compression
- Esophageal compression
Prognosis
Prognosis of de Quervain's thyroiditis is usually good.
References
- ↑ 1.0 1.1 "Thyroiditis — NEJM".
- ↑ 2.0 2.1 Engkakul P, Mahachoklertwattana P, Poomthavorn P (2011). "Eponym : de Quervain thyroiditis". Eur. J. Pediatr. 170 (4): 427–31. doi:10.1007/s00431-010-1306-4. PMID 20886353.
- ↑ 3.0 3.1 Leibovitch G, Maaravi Y, Shalev O (1989). "Severe facial oedema and glossitis associated with mianserin". Lancet. 2 (8667): 871–2. PMID 2571803.