De Quervain's thyroiditis natural history, complications, and prognosis
De Quervain's thyroiditis Microchapters
Differentiating De Quervain's thyroiditis from other Diseases
Editor-In-Chief: C. Michael Gibson, M.S., M.D. ; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S
De Quervain's thyroiditis develops after a viral prodrome and presents as painful thyroid gland with symptoms of thyrotoxicosis. It further leads to a euthyroid phase and eventually hypothyroid phase before the complete resolution of the disease. Complications include hypothyroidism and rarely, esophageal or tracheal compression.
Natural history, complications, and prognosis
De Quervain's thyroiditis develops after a viral prodrome and presents as painful thyroid gland with symptoms of thyrotoxicosis. It further leads to a euthyroid phase and eventually hypothyroid phase before the complete resolution of the disease.
1. Prodromal stage
- Low-grade fever and viral flu-like symptoms, such as sore throat, myalgia, arthralgia, and malaise.
- High-grade fever and neck pain with a tender and diffuse thyroid gland enlargement follow flu-like symptoms.
2. Hyperthyroid stage
It follows the prodromal stage and includes the symptoms of thyrotoxicosis such as:
- Tachycardia and tremors
- Irritability and nervousness
3. Euthyroid stage
Thyrotoxic stage is followed by a 1–3-week period of euthyroid phase.
4. Hypothyroid stage
The transient hypothyroid stage lasts for 6-12 months.
- Rarely, the hypothyroid stage may persist for a longer duration.
Complications that can develop as a result of de Quervain's thyroiditis are:
- Tracheal compression
- Esophageal compression
Prognosis of de Quervain's thyroiditis is usually good.
- ↑ 1.0 1.1 "Thyroiditis — NEJM".
- ↑ 2.0 2.1 Engkakul P, Mahachoklertwattana P, Poomthavorn P (2011). "Eponym : de Quervain thyroiditis". Eur. J. Pediatr. 170 (4): 427–31. doi:10.1007/s00431-010-1306-4. PMID 20886353.
- ↑ 3.0 3.1 Leibovitch G, Maaravi Y, Shalev O (1989). "Severe facial oedema and glossitis associated with mianserin". Lancet. 2 (8667): 871–2. PMID 2571803.