De Quervain's thyroiditis natural history, complications and prognosis: Difference between revisions

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{{CMG}}; {{AE}} {{MMF}}
{{CMG}}; {{AE}} {{MMF}}
==Overview==
==Overview==
De Quervain's thyroiditis develops after a viral prodrome and presents as painful thyroid gland with symptoms of [[thyrotoxicosis]]. It further leads to a [[euthyroid]] phase and eventually [[Hypothyroidism|hypothyroid]] phase before the complete resolution of the disease. Complications include [[hypothyroidism]] and rarely, [[tracheal compression|tracheal or esophageal compression]].
De Quervain's thyroiditis develops after a [[viral]] [[prodrome]] and presents as [[painful]] [[thyroid gland]] with symptoms of [[thyrotoxicosis]]. It further leads to a [[euthyroid]] phase and eventually [[Hypothyroidism|hypothyroid]] phase before the complete resolution of the disease. Complications include [[hypothyroidism]] and rarely, [[esophageal]] or [[tracheal compression|tracheal compression]].


==Natural History==
==Natural history, complications, and prognosis==
De Quervain's thyroiditis develops after a viral prodrome and presents as painful thyroid gland with symptoms of [[thyrotoxicosis]]. It further leads to a [[euthyroid]] phase and eventually [[Hypothyroidism|hypothyroid]] phase before the complete resolution of the disease.<ref name="urlThyroiditis — NEJM">{{cite web |url=http://www.nejm.org/doi/full/10.1056/NEJMra021194 |title=Thyroiditis — NEJM |format= |work= |accessdate=}}</ref><ref name="pmid20886353">{{cite journal |vauthors=Engkakul P, Mahachoklertwattana P, Poomthavorn P |title=Eponym : de Quervain thyroiditis |journal=Eur. J. Pediatr. |volume=170 |issue=4 |pages=427–31 |year=2011 |pmid=20886353 |doi=10.1007/s00431-010-1306-4 |url=}}</ref><ref name="pmid2571803">{{cite journal |vauthors=Leibovitch G, Maaravi Y, Shalev O |title=Severe facial oedema and glossitis associated with mianserin |journal=Lancet |volume=2 |issue=8667 |pages=871–2 |year=1989 |pmid=2571803 |doi= |url=}}</ref>
 
===1.Prodromal stage===
=== Natural history ===
De Quervain's thyroiditis develops after a [[viral]] [[prodrome]] and presents as [[painful]] [[thyroid gland]] with symptoms of [[thyrotoxicosis]]. It further leads to a [[euthyroid]] phase and eventually [[Hypothyroidism|hypothyroid]] phase before the complete resolution of the [[disease]].<ref name="urlThyroiditis — NEJM">{{cite web |url=http://www.nejm.org/doi/full/10.1056/NEJMra021194 |title=Thyroiditis — NEJM |format= |work= |accessdate=}}</ref><ref name="pmid20886353">{{cite journal |vauthors=Engkakul P, Mahachoklertwattana P, Poomthavorn P |title=Eponym : de Quervain thyroiditis |journal=Eur. J. Pediatr. |volume=170 |issue=4 |pages=427–31 |year=2011 |pmid=20886353 |doi=10.1007/s00431-010-1306-4 |url=}}</ref><ref name="pmid2571803">{{cite journal |vauthors=Leibovitch G, Maaravi Y, Shalev O |title=Severe facial oedema and glossitis associated with mianserin |journal=Lancet |volume=2 |issue=8667 |pages=871–2 |year=1989 |pmid=2571803 |doi= |url=}}</ref>
====1. Prodromal stage====
It includes:
It includes:
*[[Low-grade fever]] and viral flu-like symptoms, such as [[sore throat]], [[myalgia]], [[arthralgia]], and [[malaise]].
*[[Low-grade fever]] and viral flu-like symptoms, such as [[sore throat]], [[myalgia]], [[arthralgia]], and [[malaise]].
*[[Fever|High-grade fever]] and [[neck pain]] with a tender and diffuse thyroid gland enlargement follow flu-like symptoms.
*[[Fever|High-grade fever]] and [[neck pain]] with a tender and diffuse thyroid gland enlargement follow flu-like symptoms.


===1.Hyperthyroid stage===
====2. Hyperthyroid stage====
It follows the prodromal stage and includes the symptoms of [[thyrotoxicosis]] such as:
It follows the prodromal stage and includes the symptoms of [[thyrotoxicosis]] such as:
*[[Tachycardia]] and [[Tremor|tremors]].
*[[Tachycardia]] and [[Tremor|tremors]]
*[[Irritability]] and [[nervousness]].
*[[Irritability]] and [[nervousness]]


===2.Euthyroid stage===
====3. Euthyroid stage====
Thyrotoxic stage is followed by a 1–3-week period of [[Euthyroid|euthyroid phase]].
Thyrotoxic stage is followed by a 1–3-week period of [[Euthyroid|euthyroid phase]].


===4.Hypothyroid stage===
====4. Hypothyroid stage====
The transient hypothyroid stage lasts for 6-12 months.
The transient hypothyroid stage lasts for 6-12 months.
*Rarely, the [[hypothyroid]] stage may persist for a longer duration.
*Rarely, the [[hypothyroid]] stage may persist for a longer duration.


==Complications==
===Complications===
Complications that can develop as a result of de Quervain's thyroiditis are:<ref name="urlThyroiditis — NEJM">{{cite web |url=http://www.nejm.org/doi/full/10.1056/NEJMra021194 |title=Thyroiditis — NEJM |format= |work= |accessdate=}}</ref><ref name="pmid20886353">{{cite journal |vauthors=Engkakul P, Mahachoklertwattana P, Poomthavorn P |title=Eponym : de Quervain thyroiditis |journal=Eur. J. Pediatr. |volume=170 |issue=4 |pages=427–31 |year=2011 |pmid=20886353 |doi=10.1007/s00431-010-1306-4 |url=}}</ref><ref name="pmid2571803">{{cite journal |vauthors=Leibovitch G, Maaravi Y, Shalev O |title=Severe facial oedema and glossitis associated with mianserin |journal=Lancet |volume=2 |issue=8667 |pages=871–2 |year=1989 |pmid=2571803 |doi= |url=}}</ref>
Complications that can develop as a result of de Quervain's thyroiditis are:<ref name="urlThyroiditis — NEJM">{{cite web |url=http://www.nejm.org/doi/full/10.1056/NEJMra021194 |title=Thyroiditis — NEJM |format= |work= |accessdate=}}</ref><ref name="pmid20886353">{{cite journal |vauthors=Engkakul P, Mahachoklertwattana P, Poomthavorn P |title=Eponym : de Quervain thyroiditis |journal=Eur. J. Pediatr. |volume=170 |issue=4 |pages=427–31 |year=2011 |pmid=20886353 |doi=10.1007/s00431-010-1306-4 |url=}}</ref><ref name="pmid2571803">{{cite journal |vauthors=Leibovitch G, Maaravi Y, Shalev O |title=Severe facial oedema and glossitis associated with mianserin |journal=Lancet |volume=2 |issue=8667 |pages=871–2 |year=1989 |pmid=2571803 |doi= |url=}}</ref>
*[[Hypothyroidism]]
*[[Hypothyroidism]]
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*Esophageal compression
*Esophageal compression


==Prognosis==
===Prognosis===
Prognosis of de Quervain's thyroiditis is usually good.
Prognosis of de Quervain's thyroiditis is usually good.
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Latest revision as of 18:20, 18 August 2017

De Quervain's thyroiditis Microchapters

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Overview

Historical Perspective

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Pathophysiology

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Differentiating De Quervain's thyroiditis from other Diseases

Epidemiology and Demographics

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Natural History, Complications, and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

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Cost-Effectiveness of Therapy

Future or Investigational Therapies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]

Overview

De Quervain's thyroiditis develops after a viral prodrome and presents as painful thyroid gland with symptoms of thyrotoxicosis. It further leads to a euthyroid phase and eventually hypothyroid phase before the complete resolution of the disease. Complications include hypothyroidism and rarely, esophageal or tracheal compression.

Natural history, complications, and prognosis

Natural history

De Quervain's thyroiditis develops after a viral prodrome and presents as painful thyroid gland with symptoms of thyrotoxicosis. It further leads to a euthyroid phase and eventually hypothyroid phase before the complete resolution of the disease.[1][2][3]

1. Prodromal stage

It includes:

2. Hyperthyroid stage

It follows the prodromal stage and includes the symptoms of thyrotoxicosis such as:

3. Euthyroid stage

Thyrotoxic stage is followed by a 1–3-week period of euthyroid phase.

4. Hypothyroid stage

The transient hypothyroid stage lasts for 6-12 months.

  • Rarely, the hypothyroid stage may persist for a longer duration.

Complications

Complications that can develop as a result of de Quervain's thyroiditis are:[1][2][3]

Prognosis

Prognosis of de Quervain's thyroiditis is usually good.

References

  1. ↑ 1.0 1.1 "Thyroiditis — NEJM".
  2. ↑ 2.0 2.1 Engkakul P, Mahachoklertwattana P, Poomthavorn P (2011). "Eponym : de Quervain thyroiditis". Eur. J. Pediatr. 170 (4): 427–31. doi:10.1007/s00431-010-1306-4. PMID 20886353.
  3. ↑ 3.0 3.1 Leibovitch G, Maaravi Y, Shalev O (1989). "Severe facial oedema and glossitis associated with mianserin". Lancet. 2 (8667): 871–2. PMID 2571803.
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