DSC1: Difference between revisions

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*{{cite journal  | vauthors=King IA, Sullivan KH, Bennett R, Buxton RS |title=The desmocollins of human foreskin epidermis: identification and chromosomal assignment of a third gene and expression patterns of the three isoforms |journal=J. Invest. Dermatol. |volume=105 |issue= 3 |pages= 314–21 |year= 1995 |pmid= 7665906 |doi=10.1111/1523-1747.ep12319935  }}
*{{cite journal  | vauthors=King IA, Sullivan KH, Bennett R, Buxton RS |title=The desmocollins of human foreskin epidermis: identification and chromosomal assignment of a third gene and expression patterns of the three isoforms |journal=J. Invest. Dermatol. |volume=105 |issue= 3 |pages= 314–21 |year= 1995 |pmid= 7665906 |doi=10.1111/1523-1747.ep12319935  }}
*{{cite journal  | vauthors=Troyanovsky SM, Eshkind LG, Troyanovsky RB |title=Contributions of cytoplasmic domains of desmosomal cadherins to desmosome assembly and intermediate filament anchorage |journal=Cell |volume=72 |issue= 4 |pages= 561–74 |year= 1993 |pmid= 7679953 |doi=10.1016/0092-8674(93)90075-2  |display-authors=etal}}
*{{cite journal  | vauthors=Troyanovsky SM, Eshkind LG, Troyanovsky RB |title=Contributions of cytoplasmic domains of desmosomal cadherins to desmosome assembly and intermediate filament anchorage |journal=Cell |volume=72 |issue= 4 |pages= 561–74 |year= 1993 |pmid= 7679953 |doi=10.1016/0092-8674(93)90075-2  |display-authors=etal}}
*{{cite journal  | vauthors=Troyanovsky SM, Troyanovsky RB, Eshkind LG |title=Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 23 |pages= 10790–4 |year= 1994 |pmid= 7971964 |doi=10.1073/pnas.91.23.10790  | pmc=45111  |display-authors=etal}}
*{{cite journal  | vauthors=Troyanovsky SM, Troyanovsky RB, Eshkind LG |title=Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 23 |pages= 10790–4 |year= 1994 |pmid= 7971964 |doi=10.1073/pnas.91.23.10790  | pmc=45111  |display-authors=etal|bibcode=1994PNAS...9110790T}}
*{{cite journal  | vauthors=King IA, Arnemann J, Spurr NK, Buxton RS |title=Cloning of the cDNA (DSC1) coding for human type 1 desmocollin and its assignment to chromosome 18 |journal=Genomics |volume=18 |issue= 2 |pages= 185–94 |year= 1994 |pmid= 8288219 |doi= 10.1006/geno.1993.1453 }}
*{{cite journal  | vauthors=King IA, Arnemann J, Spurr NK, Buxton RS |title=Cloning of the cDNA (DSC1) coding for human type 1 desmocollin and its assignment to chromosome 18 |journal=Genomics |volume=18 |issue= 2 |pages= 185–94 |year= 1994 |pmid= 8288219 |doi= 10.1006/geno.1993.1453 }}
*{{cite journal  | vauthors=Theis DG, Koch PJ, Franke WW |title=Differential synthesis of type 1 and type 2 desmocollin mRNAs in human stratified epithelia |journal=Int. J. Dev. Biol. |volume=37 |issue= 1 |pages= 101–10 |year= 1993 |pmid= 8507556 |doi=  }}
*{{cite journal  | vauthors=Theis DG, Koch PJ, Franke WW |title=Differential synthesis of type 1 and type 2 desmocollin mRNAs in human stratified epithelia |journal=Int. J. Dev. Biol. |volume=37 |issue= 1 |pages= 101–10 |year= 1993 |pmid= 8507556 |doi=  }}

Revision as of 07:29, 23 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (protein)

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Wikidata
View/Edit Human

Desmocollin-1 is a protein that in humans is encoded by the DSC1 gene.[1][2]

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.[2]

Interactions

DSC1 has been shown to interact with Desmoglein 2.[3]

References

  1. ↑ Buxton RS, Cowin P, Franke WW, Garrod DR, Green KJ, King IA, Koch PJ, Magee AI, Rees DA, Stanley JR, et al. (Jun 1993). "Nomenclature of the desmosomal cadherins". J Cell Biol. 121 (3): 481–3. doi:10.1083/jcb.121.3.481. PMC 2119574. PMID 8486729.
  2. ↑ 2.0 2.1 "Entrez Gene: DSC1 desmocollin 1".
  3. ↑ Chitaev, N A; Troyanovsky S M (Jul 1997). "Direct Ca2+-dependent Heterophilic Interaction between Desmosomal Cadherins, Desmoglein and Desmocollin, Contributes to Cell–Cell Adhesion". J. Cell Biol. UNITED STATES. 138 (1): 193–201. doi:10.1083/jcb.138.1.193. ISSN 0021-9525. PMC 2139935. PMID 9214392.

Further reading



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