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'''Desmocollin-1''' is a [[protein]] that in humans is encoded by the ''DSC1'' [[gene]].<ref name="pmid8486729">{{cite journal | vauthors = Buxton RS, Cowin P, Franke WW, Garrod DR, Green KJ, King IA, Koch PJ, Magee AI, Rees DA, Stanley JR | title = Nomenclature of the desmosomal cadherins | journal = J Cell Biol | volume = 121 | issue = 3 | pages = 481–3 |date=Jun 1993 | pmid = 8486729 | pmc = 2119574 | doi =10.1083/jcb.121.3.481 |display-authors=etal}}</ref><ref name="entrez"/> | |||
}} | |||
'''Desmocollin 1''' | |||
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| summary_text = The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: DSC1 desmocollin 1| url = | | summary_text = The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: DSC1 desmocollin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1823| accessdate = }}</ref> | ||
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==Interactions== | |||
DSC1 has been shown to [[Protein-protein interaction|interact]] with [[Desmoglein 2]].<ref name=pmid9214392>{{cite journal |last=Chitaev |first=N A |author2=Troyanovsky S M |date=Jul 1997 |title=Direct Ca2+-dependent Heterophilic Interaction between Desmosomal Cadherins, Desmoglein and Desmocollin, Contributes to Cell–Cell Adhesion |journal=J. Cell Biol. |volume=138 |issue=1 |pages=193–201 |publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 9214392 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1083/jcb.138.1.193 |pmc=2139935 }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Garrod DR, Merritt AJ, Nie Z |title=Desmosomal cadherins |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 537–45 |year= 2003 |pmid= 12231347 |doi=10.1016/S0955-0674(02)00366-6 }} | ||
*{{cite journal | vauthors=King IA, Magee AI, Rees DA, Buxton RS |title=Keratinization is associated with the expression of a new protein related to the desmosomal cadherins DGII/III |journal=FEBS Lett. |volume=286 |issue= 1–2 |pages= 9–12 |year= 1991 |pmid= 1713860 |doi=10.1016/0014-5793(91)80929-W }} | |||
*{{cite journal | | *{{cite journal | vauthors=King IA, Sullivan KH, Bennett R, Buxton RS |title=The desmocollins of human foreskin epidermis: identification and chromosomal assignment of a third gene and expression patterns of the three isoforms |journal=J. Invest. Dermatol. |volume=105 |issue= 3 |pages= 314–21 |year= 1995 |pmid= 7665906 |doi=10.1111/1523-1747.ep12319935 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Troyanovsky SM, Eshkind LG, Troyanovsky RB |title=Contributions of cytoplasmic domains of desmosomal cadherins to desmosome assembly and intermediate filament anchorage |journal=Cell |volume=72 |issue= 4 |pages= 561–74 |year= 1993 |pmid= 7679953 |doi=10.1016/0092-8674(93)90075-2 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Troyanovsky SM, Troyanovsky RB, Eshkind LG |title=Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 23 |pages= 10790–4 |year= 1994 |pmid= 7971964 |doi=10.1073/pnas.91.23.10790 | pmc=45111 |display-authors=etal|bibcode=1994PNAS...9110790T}} | ||
*{{cite journal | | *{{cite journal | vauthors=King IA, Arnemann J, Spurr NK, Buxton RS |title=Cloning of the cDNA (DSC1) coding for human type 1 desmocollin and its assignment to chromosome 18 |journal=Genomics |volume=18 |issue= 2 |pages= 185–94 |year= 1994 |pmid= 8288219 |doi= 10.1006/geno.1993.1453 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Theis DG, Koch PJ, Franke WW |title=Differential synthesis of type 1 and type 2 desmocollin mRNAs in human stratified epithelia |journal=Int. J. Dev. Biol. |volume=37 |issue= 1 |pages= 101–10 |year= 1993 |pmid= 8507556 |doi= }} | ||
*{{cite journal | | *{{cite journal | vauthors=Nuber UA, Schäfer S, Stehr S |title=Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells |journal=Eur. J. Cell Biol. |volume=71 |issue= 1 |pages= 1–13 |year= 1997 |pmid= 8884173 |doi= |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Cowley CM, Simrak D, Marsden MD |title=A YAC contig joining the desmocollin and desmoglein loci on human chromosome 18 and ordering of the desmocollin genes |journal=Genomics |volume=42 |issue= 2 |pages= 208–16 |year= 1997 |pmid= 9192840 |doi= 10.1006/geno.1997.4718 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Chitaev NA, Troyanovsky SM |title=Direct Ca2+-dependent Heterophilic Interaction between Desmosomal Cadherins, Desmoglein and Desmocollin, Contributes to Cell–Cell Adhesion |journal=J. Cell Biol. |volume=138 |issue= 1 |pages= 193–201 |year= 1997 |pmid= 9214392 |doi=10.1083/jcb.138.1.193 | pmc=2139935 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Smith EA, Fuchs E |title=Defining the Interactions Between Intermediate Filaments and Desmosomes |journal=J. Cell Biol. |volume=141 |issue= 5 |pages= 1229–41 |year= 1998 |pmid= 9606214 |doi=10.1083/jcb.141.5.1229 | pmc=2137181 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Kurzen H, Moll I, Moll R |title=Compositionally different desmosomes in the various compartments of the human hair follicle |journal=Differentiation |volume=63 |issue= 5 |pages= 295–304 |year= 1998 |pmid= 9810708 |doi=10.1046/j.1432-0436.1998.6350295.x |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Hunt DM, Sahota VK, Taylor K |title=Clustered cadherin genes: a sequence-ready contig for the desmosomal cadherin locus on human chromosome 18 |journal=Genomics |volume=62 |issue= 3 |pages= 445–55 |year= 2000 |pmid= 10644442 |doi= 10.1006/geno.1999.6036 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Whittock NV, Hunt DM, Rickman L |title=Genomic organization and amplification of the human desmosomal cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3 |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 2 |pages= 454–60 |year= 2000 |pmid= 11027496 |doi= 10.1006/bbrc.2000.3500 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Ishii K, Norvell SM, Bannon LJ |title=Assembly of desmosomal cadherins into desmosomes is isoform dependent |journal=J. Invest. Dermatol. |volume=117 |issue= 1 |pages= 26–35 |year= 2001 |pmid= 11442746 |doi= 10.1046/j.0022-202x.2001.01400.x |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Chen X, Bonne S, Hatzfeld M |title=Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10512–22 |year= 2002 |pmid= 11790773 |doi= 10.1074/jbc.M108765200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Bonné S, Gilbert B, Hatzfeld M |title=Defining desmosomal plakophilin-3 interactions |journal=J. Cell Biol. |volume=161 |issue= 2 |pages= 403–16 |year= 2003 |pmid= 12707304 |doi= 10.1083/jcb.200303036 | pmc=2172904 |display-authors=etal}} | ||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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{{Cell adhesion molecules}} | |||
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Desmocollin-1 is a protein that in humans is encoded by the DSC1 gene.[1][2]
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.[2]
Interactions
DSC1 has been shown to interact with Desmoglein 2.[3]
References
- ↑ Buxton RS, Cowin P, Franke WW, Garrod DR, Green KJ, King IA, Koch PJ, Magee AI, Rees DA, Stanley JR, et al. (Jun 1993). "Nomenclature of the desmosomal cadherins". J Cell Biol. 121 (3): 481–3. doi:10.1083/jcb.121.3.481. PMC 2119574. PMID 8486729.
- ↑ 2.0 2.1 "Entrez Gene: DSC1 desmocollin 1".
- ↑ Chitaev, N A; Troyanovsky S M (Jul 1997). "Direct Ca2+-dependent Heterophilic Interaction between Desmosomal Cadherins, Desmoglein and Desmocollin, Contributes to Cell–Cell Adhesion". J. Cell Biol. UNITED STATES. 138 (1): 193–201. doi:10.1083/jcb.138.1.193. ISSN 0021-9525. PMC 2139935. PMID 9214392.
Further reading
- Garrod DR, Merritt AJ, Nie Z (2003). "Desmosomal cadherins". Curr. Opin. Cell Biol. 14 (5): 537–45. doi:10.1016/S0955-0674(02)00366-6. PMID 12231347.
- King IA, Magee AI, Rees DA, Buxton RS (1991). "Keratinization is associated with the expression of a new protein related to the desmosomal cadherins DGII/III". FEBS Lett. 286 (1–2): 9–12. doi:10.1016/0014-5793(91)80929-W. PMID 1713860.
- King IA, Sullivan KH, Bennett R, Buxton RS (1995). "The desmocollins of human foreskin epidermis: identification and chromosomal assignment of a third gene and expression patterns of the three isoforms". J. Invest. Dermatol. 105 (3): 314–21. doi:10.1111/1523-1747.ep12319935. PMID 7665906.
- Troyanovsky SM, Eshkind LG, Troyanovsky RB, et al. (1993). "Contributions of cytoplasmic domains of desmosomal cadherins to desmosome assembly and intermediate filament anchorage". Cell. 72 (4): 561–74. doi:10.1016/0092-8674(93)90075-2. PMID 7679953.
- Troyanovsky SM, Troyanovsky RB, Eshkind LG, et al. (1994). "Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 10790–4. Bibcode:1994PNAS...9110790T. doi:10.1073/pnas.91.23.10790. PMC 45111. PMID 7971964.
- King IA, Arnemann J, Spurr NK, Buxton RS (1994). "Cloning of the cDNA (DSC1) coding for human type 1 desmocollin and its assignment to chromosome 18". Genomics. 18 (2): 185–94. doi:10.1006/geno.1993.1453. PMID 8288219.
- Theis DG, Koch PJ, Franke WW (1993). "Differential synthesis of type 1 and type 2 desmocollin mRNAs in human stratified epithelia". Int. J. Dev. Biol. 37 (1): 101–10. PMID 8507556.
- Nuber UA, Schäfer S, Stehr S, et al. (1997). "Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells". Eur. J. Cell Biol. 71 (1): 1–13. PMID 8884173.
- Cowley CM, Simrak D, Marsden MD, et al. (1997). "A YAC contig joining the desmocollin and desmoglein loci on human chromosome 18 and ordering of the desmocollin genes". Genomics. 42 (2): 208–16. doi:10.1006/geno.1997.4718. PMID 9192840.
- Chitaev NA, Troyanovsky SM (1997). "Direct Ca2+-dependent Heterophilic Interaction between Desmosomal Cadherins, Desmoglein and Desmocollin, Contributes to Cell–Cell Adhesion". J. Cell Biol. 138 (1): 193–201. doi:10.1083/jcb.138.1.193. PMC 2139935. PMID 9214392.
- Smith EA, Fuchs E (1998). "Defining the Interactions Between Intermediate Filaments and Desmosomes". J. Cell Biol. 141 (5): 1229–41. doi:10.1083/jcb.141.5.1229. PMC 2137181. PMID 9606214.
- Kurzen H, Moll I, Moll R, et al. (1998). "Compositionally different desmosomes in the various compartments of the human hair follicle". Differentiation. 63 (5): 295–304. doi:10.1046/j.1432-0436.1998.6350295.x. PMID 9810708.
- Hunt DM, Sahota VK, Taylor K, et al. (2000). "Clustered cadherin genes: a sequence-ready contig for the desmosomal cadherin locus on human chromosome 18". Genomics. 62 (3): 445–55. doi:10.1006/geno.1999.6036. PMID 10644442.
- Whittock NV, Hunt DM, Rickman L, et al. (2000). "Genomic organization and amplification of the human desmosomal cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3". Biochem. Biophys. Res. Commun. 276 (2): 454–60. doi:10.1006/bbrc.2000.3500. PMID 11027496.
- Ishii K, Norvell SM, Bannon LJ, et al. (2001). "Assembly of desmosomal cadherins into desmosomes is isoform dependent". J. Invest. Dermatol. 117 (1): 26–35. doi:10.1046/j.0022-202x.2001.01400.x. PMID 11442746.
- Chen X, Bonne S, Hatzfeld M, et al. (2002). "Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling". J. Biol. Chem. 277 (12): 10512–22. doi:10.1074/jbc.M108765200. PMID 11790773.
- Bonné S, Gilbert B, Hatzfeld M, et al. (2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904. PMID 12707304.
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