DRESS syndrome natural history, complications and prognosis

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DRESS syndrome Microchapters

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Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating DRESS syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

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Treatment

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Cost-Effectiveness of Therapy

Future or Investigational Therapies

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Natural History

  • DRESS syndrome is characterized by a prolonged latency period.
  • Clinical manifestations of DRESS syndrome are usually delayed 2-8 weeks following the administration of triggering drug.
  • Initially, patients usually develop non-specific signs and symptoms, namely fever and rash.
  • Additional clinical manifestations follow, and patients may subsequently develop lymphadenopathy, visceral disease, and worsening of the skin eruption.
  • In the majority of cases, DRESS syndrome resolves following the discontinuation of triggering drug, but clinical manifestations may persist up to 3 months.

Complications

  • Organ involvement is considered the most important complication of DRESS syndrome.
  • Complications of DRESS syndrome include the following:

Prognosis

References