Cirrhosis (patient information)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Jinhui Wu, MD

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What is cirrhosis?

How do I know if I have cirrhosis and what are the symptoms of cirrhosis?

Early cirrhosis does not have any symptoms. However, as the disease progresses, a person may experience the following symptoms:

Other health problems may also cause these symptoms. Only a doctor can tell for sure. A person with any of these symptoms should tell the doctor so that the problems can be diagnosed and treated as early as possible.

Who is at risk for cirrhosis?

Cirrhosis can be caused by many things, some known and others unknown:

  • Chronic alcohol abuse: This is the most common cause of cirrhosis in the United States and other western countries.
  • Chronic Hepatitis B and C viruses and perhaps other viruses, can damage the liver over a prolonged time and eventually cause cirrhosis. This is the most common cause of cirrhosis in some Asian countries.
  • Autoimmune hepatitis: The body's protective antibodies injure the liver cells because they fail to recognize the liver as its own tissue.
  • Chronic bile duct blockage
  • Wilson's Disease or hemochromatosis: Tetals are present in all body cells. When abnormal amounts of them accumulate in the liver, scarring and cirrhosis may develop.
  • Cystic fibrosis and Alpha l-antitrypsin deficiency
  • Nonalcoholic fatty liver disease
  • Drugs and toxins: Studies demonstrate that prolonged exposure to certain chemicals or drugs can damage the liver.

How to know you have cirrhosis?

  • Blood tests: Blood tests such as a complete blood count, bilirubin test, coagulation study and liver function tests to determine the cause of cirrhosis, and assess liver function and coagulation function.
  • Imaging procedures and liver biopsy: Images studies such as ultrasound, computerized tomography (CT), and magnetic resonance imaging (MRI) can show the constructure of liver and organs nearby. These images tests can also be used to guide biopsy and a biopsy sample is usually removed and looked at under a microscope by a pathologist. Liver biopsy can tell valuable information about the disease.

When to seek urgent medical care?

Call your health care provider if symptoms of cirrhosis develop. If you experience either of the following symptoms, seeking urgent medical care as soon as possible:

Treatment options

The goals of treatment of cirrhosis are to slow the progression of scar tissue in the liver and prevent or treat the complications of the disease. Treatment options depend on the underling cause and whether complications are present. Hospitalization may be necessary for cirrhosis with complications.

  • Diet: Eating a nutritious diet is very important in all stages of cirrhosis. To improve nutrition, sometimes the doctor may add a liquid supplement taken by mouth or through a nasogastric tube. If ascites develops, a sodium-restricted diet is recommended.
  • Treatments on the specific causes of cirrhosis: Interferon and other antiviral drugs may be prescribed for viral hepatitis, and autoimmune hepatitis requires corticosteroids and other drugs that suppress the immune system.
  • Avoiding alcohol: The alcoholic patient must permanently stop consuming alcohol.
  • Edema and ascites: For edema and ascites, diuretics will be recommended to remove fluid from the body. Large amounts of ascitic fluid may be removed from the abdomen and checked for bacterial peritonitis.
  • Infections: Oral antibiotics may be prescribed to prevent infection. Severe infection with ascites will require intravenous antibiotics.
  • Portal hypertension: The doctor may prescribe a beta-blocker or nitrate to control portal hypertension and reduce the risk of bleeding.
  • Gastrointestinal bleeding: This severe complication requires an immediate upper endoscopy to look for esophageal varices and to compress the varices to stop the bleeding. People who have had varices in the past may need to take medicine to prevent future episodes.
  • Hepatic encephalopathy: At first, the patient may be asked to reduce dietary protein intake. Then, lactulose may be prescribed by oral or in enemas to cleanse the bowel. If necessary, antibiotics are added to the treatment.
  • Hepatorenal failure: These patients must undergo regular hemodialysis treatment to improve blood flow through the kidneys.
  • Symptomatic treatment: Medications are given to treat various symptoms of cirrhosis, such as itching and constipation.

Diseases with similar symptoms

Where to find medical care for cirrhosis?

Directions to Hospitals Treating cirrhosis

Prevention of cirrhosis

What to expect (Outook/Prognosis)?

Copyleft Sources

http://digestive.niddk.nih.gov/ddiseases/pubs/cirrhosis/index.htm

http://www.mayoclinic.com/print/cirrhosis/DS00373/DSECTION=all&METHOD=print

http://www.hepatitis.va.gov/vahep?page=cirrh-00-00

http://www.gicare.com/diseases/Cirrhosis.aspx

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