Ciclopirox

Ciclopirox
	File:Ciclopirox.svg
Clinical data
Routes of; administration	Topical (applied as a nail lacquer)
ATC code	D01AE14 (WHO) G01AX12 (WHO);
Legal status
Legal status	US: ℞-only ; OTC(CA);
Pharmacokinetic data
Bioavailability	<5% with prolonged use
Protein binding	94 to 97%
Elimination half-life	1.7 hours
Identifiers
	IUPAC name 6-cyclohexyl-1-hydroxy-4-methyl-pyridin-2-one;
CAS Number	29342-05-0;
PubChem CID	2749;
DrugBank	APRD00871;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C12H17NO2
Molar mass	207.269 g/mol

Ciclopirox olamine (also called Loprox®, Penlac® and Stieprox®) is a synthetic antifungal agent for topical dermatologic use. It acts by inhibiting the membrane transfer system by interrupting the Na⁺ K⁺ ATPase.^[1]

References

↑ Niewerth M, Kunze D, Seibold M, Schaller M, Korting HC, Hube B (2003). "Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors". Antimicrob. Agents Chemother. 47 (6): 1805–17. PMID 12760852.

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[pmid12760852-1] Niewerth M, Kunze D, Seibold M, Schaller M, Korting HC, Hube B (2003). "Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors". Antimicrob. Agents Chemother. 47 (6): 1805–17. PMID 12760852.

[1]

v t e Antifungals (D01 and J02)
Antibiotics	Griseofulvin • polyene antimycotics (Natamycin, Nystatin)
Topical azoles	imidazoles (Bifonazole, Clomidazole, Clotrimazole, Econazole, Fenticonazole, Ketoconazole, Isoconazole, Miconazole, Oxiconazole, Sertaconazole, Sulconazole, Tioconazole) • triazoles (Fluconazole) • benzimidazole (Thiabendazole)
Other topicals	Ciclopirox • Ethylparaben • Flucytosine • Salicylic acid • Selenium sulfide • Tolnaftate • Undecylenic acid • allylamines (Amorolfine, Butenafine, Naftifine, Terbinafine)
For systemic use	Griseofulvin • allylamine (Terbinafine) • polyene antimycotic (Amphotericin B) • triazoles (Itraconazole, Posaconazole, Voriconazole) • echinocandins (Anidulafungin, Caspofungin, Micafungin)
Other	Tea tree oil • citronella oil • lemon grass • orange oil • patchouli • lemon myrtle

v t e Gynecological anti-infectives and antiseptics (G01)
Antibiotics	polyene antimycotic (Nystatin, Natamycin, Amphotericin B) - Candicidin - Chloramphenicol - Hachimycin - Oxytetracycline - Carfecillin - Mepartricin - Clindamycin - Pentamycin
Arsenic compounds	Acetarsol
Quinoline derivatives	Diiodohydroxyquinoline - Clioquinol - Chlorquinaldol - Dequalinium - Broxyquinoline - Oxyquinoline
Organic acids	Lactic acid - Acetic acid - Ascorbic acid
Sulfonamides	Sulfatolamide
Imidazole derivatives	Metronidazole - Clotrimazole - Miconazole - Econazole - Ornidazole - Isoconazole - Tioconazole - Ketoconazole - Fenticonazole - Azanidazole - Propenidazole - Butoconazole - Omoconazole - Oxiconazole - Flutrimazole
Triazole derivatives	Terconazole
Other	Clodantoin - Inosine - Policresulen - Nifuratel - Furazolidone - Methylrosaniline - Povidone-iodine - Ciclopirox - Protiofate - Lactobacillus fermentum - Copper usnate

Clinical data
File:Ciclopirox.svg
Routes of administration	Topical (applied as a nail lacquer)
ATC code	D01AE14 (WHO) G01AX12 (WHO)
Legal status
Legal status	US: ℞-only OTC(CA)
Pharmacokinetic data
Bioavailability	<5% with prolonged use
Protein binding	94 to 97%
Elimination half-life	1.7 hours
Identifiers
IUPAC name 6-cyclohexyl-1-hydroxy-4-methyl-pyridin-2-one
CAS Number	29342-05-0
PubChem CID	2749
DrugBank	APRD00871
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₂H₁₇NO₂
Molar mass	207.269 g/mol

Ciclopirox

References

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