Chondrosarcoma pathophysiology: Difference between revisions
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{{CMG}};{{AE}}{{SM}} | {{CMG}};{{AE}}{{SM}} | ||
==Overview== | |||
==Pathophysiology== | ==Pathophysiology== | ||
===Microscopic Pathology=== | ===Microscopic Pathology=== | ||
Each chondrosarcoma subtype has specific characteristics: | |||
====Myxoid chondrosarcoma==== | |||
*[[Myxoid]] background. | |||
*small cells with eosinophilic cytoplasm. | |||
====Clear cell chondrosarcoma==== | |||
*Lobules of uniform to polymorphic densely-packed large cells. | |||
*Well defined pushing borders. | |||
*Clear to intensively acidophilic granular cytoplasm with vacuoles. | |||
*Central nuclei with occasional prominent nucleoli. | |||
*Low mitotic rate. | |||
*Clear cell areas lack production of hyaline chondroid matrix. | |||
*Areas with osteoclast-type giant cells mixed with small trabeculae of reactive bone. | |||
*May contain conventional low-grade chondrosarcoma. | |||
*May have secondary aneurysmal bone cyst changes. | |||
====Extraskeletal myxoid chondrosarcoma==== | |||
Shown below is a micrograph of chondrosarcoma.(H&E stain) | Shown below is a micrograph of chondrosarcoma.(H&E stain) | ||
Revision as of 14:36, 27 August 2015
Chondrosarcoma Microchapters |
Diagnosis |
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Treatment |
Case Studies |
Chondrosarcoma pathophysiology On the Web |
American Roentgen Ray Society Images of Chondrosarcoma pathophysiology |
Risk calculators and risk factors for Chondrosarcoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Shivali Marketkar, M.B.B.S. [2]
Overview
Pathophysiology
Microscopic Pathology
Each chondrosarcoma subtype has specific characteristics:
Myxoid chondrosarcoma
- Myxoid background.
- small cells with eosinophilic cytoplasm.
Clear cell chondrosarcoma
- Lobules of uniform to polymorphic densely-packed large cells.
- Well defined pushing borders.
- Clear to intensively acidophilic granular cytoplasm with vacuoles.
- Central nuclei with occasional prominent nucleoli.
- Low mitotic rate.
- Clear cell areas lack production of hyaline chondroid matrix.
- Areas with osteoclast-type giant cells mixed with small trabeculae of reactive bone.
- May contain conventional low-grade chondrosarcoma.
- May have secondary aneurysmal bone cyst changes.
Extraskeletal myxoid chondrosarcoma
Shown below is a micrograph of chondrosarcoma.(H&E stain)
Video
Below is a video of Extraskeletal Myxoid chondrosarcoma {{#ev:youtube|DxljkFd9xew}}