Chondrosarcoma differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Rohan A. Bhimani, M.B.B.S., D.N.B., M.Ch.[2]

Overview

Chondrosarcoma must be differentiated from other diseases such as chondroma, enchondroma, osteochondroma, and osteosarcoma.

Chondrosarcoma must be differentiated from following bone disorders:^[1]^[2]^[3]^[4]

Disease	Malignant lesion in patients > 40 years	chondrogenic Histology	Sacral lesions in elderly	Treatment is wide resection alone
Chondrosarcoma	+	+	+	+
Metastic disease	+	-	+	-
Lymphoma	+	-	+	-
Myeloma	+	-	+	-
Malignant Fibrous Histiocytoma	+	-	+	-
Secondary sarcoma	+	-	-	-
Enchondroma	-	+	-	-
Periosteal chondroma	-	+	-	-
Osteochondroma	-	+	-	-
Parosteal osteosarcoma	-	-	-	+
Adamantinoma	-	-	-	+
Chordoma	-	-	-	+
Squamous cell carcinoma	-	-	-	+

↑ Peabody, Terrance (2014). Orthopaedic oncology : primary and metastatic tumors of the skeletal system. Cham: Springer. ISBN 9783319073224.
↑ Czerniak, Bogdan (2016). Dorfman and Czerniak's bone tumors. Philadelphia, PA: Elsevier/Saunders. ISBN 9780323023962.
↑ Frassica FJ, Unni KK, Beabout JW, Sim FH (1986). "Dedifferentiated chondrosarcoma. A report of the clinicopathological features and treatment of seventy-eight cases". J Bone Joint Surg Am. 68 (8): 1197–205. PMID 3021775.
↑ Björnsson J, McLeod RA, Unni KK, Ilstrup DM, Pritchard DJ (1998). "Primary chondrosarcoma of long bones and limb girdles". Cancer. 83 (10): 2105–19. PMID 9827715.