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{{Infobox_gene}}
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'''Centromere protein F''' is a [[protein]] that in humans is encoded by the ''CENPF'' [[gene]].<ref name="pmid7904902">{{cite journal | vauthors = Rattner JB, Rao A, Fritzler MJ, Valencia DW, Yen TJ | title = CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization | journal = [[Cell Motil Cytoskeleton]] | volume = 26 | issue = 3 | pages = 214–26 |date=Mar 1994 | pmid = 7904902 | pmc =  | doi = 10.1002/cm.970260305 }}</ref><ref name="pmid7851898">{{cite journal | vauthors = Testa JR, Zhou JY, Bell DW, Yen TJ | title = Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24→q25 and 1q32→q41, respectively, by fluorescence in situ hybridization | journal = Genomics | volume = 23 | issue = 3 | pages = 691–3 |date=Mar 1995 | pmid = 7851898 | pmc =  | doi = 10.1006/geno.1994.1558 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CENPF centromere protein F, 350/400ka (mitosin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1063| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Centromere protein F, 350/400ka (mitosin)
| HGNCid = 1857
| Symbol = CENPF
| AltSymbols =; CENF; PRO1779; hcp-1
| OMIM = 600236
| ECnumber = 
| Homologene = 22969
| MGIid = 1313302
| Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0045502 |text = dynein binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
  | Component = {{GNF_GO|id=GO:0000776 |text = kinetochore}} {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0000922 |text = spindle pole}} {{GNF_GO|id=GO:0000940 |text = outer kinetochore of condensed chromosome}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005694 |text = chromosome}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016363 |text = nuclear matrix}}
| Process = {{GNF_GO|id=GO:0000085 |text = G2 phase of mitotic cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007094 |text = mitotic cell cycle spindle assembly checkpoint}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0016202 |text = regulation of striated muscle development}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0042493 |text = response to drug}} {{GNF_GO|id=GO:0051301 |text = cell division}} {{GNF_GO|id=GO:0051310 |text = metaphase plate congression}} {{GNF_GO|id=GO:0051382 |text = kinetochore assembly}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1063
    | Hs_Ensembl = ENSG00000117724
    | Hs_RefseqProtein = NP_057427
    | Hs_RefseqmRNA = NM_016343
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 212843161
    | Hs_GenLoc_end = 212904554
    | Hs_Uniprot =   
    | Mm_EntrezGene = 108000
    | Mm_Ensembl = ENSMUSG00000026605
    | Mm_RefseqmRNA = XM_001001047
    | Mm_RefseqProtein = XP_001001047
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 191342437
    | Mm_GenLoc_end = 191388874
    | Mm_Uniprot = 
  }}
}}
'''Centromere protein F, 350/400ka (mitosin)''', also known as '''CENPF''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CENPF centromere protein F, 350/400ka (mitosin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1063| accessdate = }}</ref>


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{{PBB_Summary
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| section_title =  
| section_title =  
| summary_text = This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.<ref name="entrez">{{cite web | title = Entrez Gene: CENPF centromere protein F, 350/400ka (mitosin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1063| accessdate = }}</ref>
| summary_text = This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CENPF}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ma L, Zhao X, Zhu X |title=Mitosin/CENP-F in mitosis, transcriptional control, and differentiation. |journal=J. Biomed. Sci. |volume=13 |issue= 2 |pages= 205-13 |year= 2006 |pmid= 16456711 |doi= 10.1007/s11373-005-9057-3 }}
*{{cite journal  | vauthors=Ma L, Zhao X, Zhu X |title=Mitosin/CENP-F in mitosis, transcriptional control, and differentiation. |journal=J. Biomed. Sci. |volume=13 |issue= 2 |pages= 205–13 |year= 2006 |pmid= 16456711 |doi= 10.1007/s11373-005-9057-3 }}
*{{cite journal  | author=Liao H, Winkfein RJ, Mack G, ''et al.'' |title=CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis. |journal=J. Cell Biol. |volume=130 |issue= 3 |pages= 507-18 |year= 1995 |pmid= 7542657 |doi=  }}
*{{cite journal  | vauthors=Liao H, Winkfein RJ, Mack G |title=CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis. |journal=J. Cell Biol. |volume=130 |issue= 3 |pages= 507–18 |year= 1995 |pmid= 7542657 |doi=10.1083/jcb.130.3.507 | pmc=2120529  |display-authors=etal}}
*{{cite journal  | author=Li Q, Ke Y, Kapp JA, ''et al.'' |title=A novel cell-cycle-dependent 350-kDa nuclear protein: C-terminal domain sufficient for nuclear localization. |journal=Biochem. Biophys. Res. Commun. |volume=212 |issue= 1 |pages= 220-8 |year= 1995 |pmid= 7612011 |doi=  }}
*{{cite journal  | vauthors=Li Q, Ke Y, Kapp JA |title=A novel cell-cycle-dependent 350-kDa nuclear protein: C-terminal domain sufficient for nuclear localization. |journal=Biochem. Biophys. Res. Commun. |volume=212 |issue= 1 |pages= 220–8 |year= 1995 |pmid= 7612011 |doi=10.1006/bbrc.1995.1959 |display-authors=etal}}
*{{cite journal  | author=Zhu X, Chang KH, He D, ''et al.'' |title=The C terminus of mitosin is essential for its nuclear localization, centromere/kinetochore targeting, and dimerization. |journal=J. Biol. Chem. |volume=270 |issue= 33 |pages= 19545-50 |year= 1995 |pmid= 7642639 |doi=  }}
*{{cite journal  | vauthors=Zhu X, Chang KH, He D |title=The C terminus of mitosin is essential for its nuclear localization, centromere/kinetochore targeting, and dimerization. |journal=J. Biol. Chem. |volume=270 |issue= 33 |pages= 19545–50 |year= 1995 |pmid= 7642639 |doi=10.1074/jbc.270.33.19545 |display-authors=etal}}
*{{cite journal  | author=Zhu X, Mancini MA, Chang KH, ''et al.'' |title=Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 5017-29 |year= 1995 |pmid= 7651420 |doi=  }}
*{{cite journal  | vauthors=Zhu X, Mancini MA, Chang KH |title=Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 5017–29 |year= 1995 |pmid= 7651420 |doi=  | pmc=230749  |display-authors=etal}}
*{{cite journal  | author=Testa JR, Zhou JY, Bell DW, Yen TJ |title=Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24-->q25 and 1q32-->q41, respectively, by fluorescence in situ hybridization. |journal=Genomics |volume=23 |issue= 3 |pages= 691-3 |year= 1995 |pmid= 7851898 |doi= 10.1006/geno.1994.1558 }}
*{{cite journal  | vauthors=Li S, Ku CY, Farmer AA |title=Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs. |journal=J. Biol. Chem. |volume=273 |issue= 11 |pages= 6183–9 |year= 1998 |pmid= 9497340 |doi=10.1074/jbc.273.11.6183  |display-authors=etal}}
*{{cite journal  | author=Rattner JB, Rao A, Fritzler MJ, ''et al.'' |title=CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization. |journal=Cell Motil. Cytoskeleton |volume=26 |issue= 3 |pages= 214-26 |year= 1994 |pmid= 7904902 |doi= 10.1002/cm.970260305 }}
*{{cite journal  | vauthors=Chan GK, Schaar BT, Yen TJ |title=Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. |journal=J. Cell Biol. |volume=143 |issue= 1 |pages= 49–63 |year= 1998 |pmid= 9763420 |doi=10.1083/jcb.143.1.49  | pmc=2132809  }}
*{{cite journal  | author=Li S, Ku CY, Farmer AA, ''et al.'' |title=Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs. |journal=J. Biol. Chem. |volume=273 |issue= 11 |pages= 6183-9 |year= 1998 |pmid= 9497340 |doi=  }}
*{{cite journal  | author=Zhu X |title=Structural requirements and dynamics of mitosin-kinetochore interaction in M phase. |journal=Mol. Cell. Biol. |volume=19 |issue= 2 |pages= 1016–24 |year= 1999 |pmid= 9891037 |doi= | pmc=116032 }}
*{{cite journal  | author=Chan GK, Schaar BT, Yen TJ |title=Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. |journal=J. Cell Biol. |volume=143 |issue= 1 |pages= 49-63 |year= 1998 |pmid= 9763420 |doi=  }}
*{{cite journal  | vauthors=Erlanson M, Casiano CA, Tan EM |title=Immunohistochemical analysis of the proliferation associated nuclear antigen CENP-F in non-Hodgkin's lymphoma. |journal=Mod. Pathol. |volume=12 |issue= 1 |pages= 69–74 |year= 1999 |pmid= 9950165 |doi=  |display-authors=etal}}
*{{cite journal  | author=Zhu X |title=Structural requirements and dynamics of mitosin-kinetochore interaction in M phase. |journal=Mol. Cell. Biol. |volume=19 |issue= 2 |pages= 1016-24 |year= 1999 |pmid= 9891037 |doi=  }}
*{{cite journal  | vauthors=Goodwin RL, Pabón-Peña LM, Foster GC, Bader D |title=The cloning and analysis of LEK1 identifies variations in the LEK/centromere protein F/mitosin gene family. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18597–604 |year= 1999 |pmid= 10373470 |doi=10.1074/jbc.274.26.18597 }}
*{{cite journal  | author=Erlanson M, Casiano CA, Tan EM, ''et al.'' |title=Immunohistochemical analysis of the proliferation associated nuclear antigen CENP-F in non-Hodgkin's lymphoma. |journal=Mod. Pathol. |volume=12 |issue= 1 |pages= 69-74 |year= 1999 |pmid= 9950165 |doi= }}
*{{cite journal  | vauthors=Ashar HR, James L, Gray K |title=Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30451–7 |year= 2000 |pmid= 10852915 |doi= 10.1074/jbc.M003469200 |display-authors=etal}}
*{{cite journal  | author=Goodwin RL, Pabón-Peña LM, Foster GC, Bader D |title=The cloning and analysis of LEK1 identifies variations in the LEK/centromere protein F/mitosin gene family. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18597-604 |year= 1999 |pmid= 10373470 |doi= }}
*{{cite journal  | vauthors=Kobayashi M, Hanai R |title=M phase-specific association of human topoisomerase IIIbeta with chromosomes. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 1 |pages= 282–7 |year= 2001 |pmid= 11549288 |doi= 10.1006/bbrc.2001.5580 }}
*{{cite journal  | author=Ashar HR, James L, Gray K, ''et al.'' |title=Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30451-7 |year= 2000 |pmid= 10852915 |doi= 10.1074/jbc.M003469200 }}
*{{cite journal  | vauthors=Hussein D, Taylor SS |title=Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis. |journal=J. Cell Sci. |volume=115 |issue= Pt 17 |pages= 3403–14 |year= 2003 |pmid= 12154071 |doi= }}
*{{cite journal  | author=Kobayashi M, Hanai R |title=M phase-specific association of human topoisomerase IIIbeta with chromosomes. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 1 |pages= 282-7 |year= 2001 |pmid= 11549288 |doi= 10.1006/bbrc.2001.5580 }}
*{{cite journal  | vauthors=Holstein SA, Hohl RJ |title=Synergistic interaction of lovastatin and paclitaxel in human cancer cells. |journal=Mol. Cancer Ther. |volume=1 |issue= 2 |pages= 141–9 |year= 2003 |pmid= 12467231 |doi= }}
*{{cite journal  | author=Hussein D, Taylor SS |title=Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis. |journal=J. Cell. Sci. |volume=115 |issue= Pt 17 |pages= 3403-14 |year= 2003 |pmid= 12154071 |doi=  }}
*{{cite journal  | vauthors=Konstantinidou AE, Korkolopoulou P, Kavantzas N |title=Mitosin, a novel marker of cell proliferation and early recurrence in intracranial meningiomas. |journal=Histol. Histopathol. |volume=18 |issue= 1 |pages= 67–74 |year= 2003 |pmid= 12507285 |doi=  |display-authors=etal}}
*{{cite journal  | author=Holstein SA, Hohl RJ |title=Synergistic interaction of lovastatin and paclitaxel in human cancer cells. |journal=Mol. Cancer Ther. |volume=1 |issue= 2 |pages= 141-9 |year= 2003 |pmid= 12467231 |doi= }}
*{{cite journal  | vauthors=Yang ZY, Guo J, Li N |title=Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. |journal=Cell Res. |volume=13 |issue= 4 |pages= 275–83 |year= 2004 |pmid= 12974617 |doi= 10.1038/sj.cr.7290172 |display-authors=etal}}
*{{cite journal  | author=Konstantinidou AE, Korkolopoulou P, Kavantzas N, ''et al.'' |title=Mitosin, a novel marker of cell proliferation and early recurrence in intracranial meningiomas. |journal=Histol. Histopathol. |volume=18 |issue= 1 |pages= 67-74 |year= 2003 |pmid= 12507285 |doi= }}
*{{cite journal  | vauthors=Laoukili J, Kooistra MR, Brás A |title=FoxM1 is required for execution of the mitotic programme and chromosome stability. |journal=Nat. Cell Biol. |volume=7 |issue= 2 |pages= 126–36 |year= 2005 |pmid= 15654331 |doi= 10.1038/ncb1217 |display-authors=etal}}
*{{cite journal  | author=Yang ZY, Guo J, Li N, ''et al.'' |title=Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. |journal=Cell Res. |volume=13 |issue= 4 |pages= 275-83 |year= 2004 |pmid= 12974617 |doi= 10.1038/sj.cr.7290172 }}
*{{cite journal  | vauthors=Zhou X, Wang R, Fan L |title=Mitosin/CENP-F as a negative regulator of activating transcription factor-4. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13973–7 |year= 2005 |pmid= 15677469 |doi= 10.1074/jbc.M414310200 |display-authors=etal}}
*{{cite journal  | author=Laoukili J, Kooistra MR, Brás A, ''et al.'' |title=FoxM1 is required for execution of the mitotic programme and chromosome stability. |journal=Nat. Cell Biol. |volume=7 |issue= 2 |pages= 126-36 |year= 2005 |pmid= 15654331 |doi= 10.1038/ncb1217 }}
*{{cite journal  | author=Zhou X, Wang R, Fan L, ''et al.'' |title=Mitosin/CENP-F as a negative regulator of activating transcription factor-4. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13973-7 |year= 2005 |pmid= 15677469 |doi= 10.1074/jbc.M414310200 }}
}}
}}
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{{refend}}


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Latest revision as of 19:32, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Centromere protein F is a protein that in humans is encoded by the CENPF gene.[1][2][3]

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.[3]

References

  1. ↑ Rattner JB, Rao A, Fritzler MJ, Valencia DW, Yen TJ (Mar 1994). "CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization". Cell Motil Cytoskeleton. 26 (3): 214–26. doi:10.1002/cm.970260305. PMID 7904902.
  2. ↑ Testa JR, Zhou JY, Bell DW, Yen TJ (Mar 1995). "Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24→q25 and 1q32→q41, respectively, by fluorescence in situ hybridization". Genomics. 23 (3): 691–3. doi:10.1006/geno.1994.1558. PMID 7851898.
  3. ↑ 3.0 3.1 "Entrez Gene: CENPF centromere protein F, 350/400ka (mitosin)".

External links

Further reading



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