CEBPE
| CCAAT/enhancer binding protein (C/EBP), epsilon | |||||||||||
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| Symbols | CEBPE ; C/EBP-epsilon; CRP1 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 1367 | ||||||||||
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| Species | Human | Mouse | |||||||||
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CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CHOP, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene.[1]. It is proapoptotic.
The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.[1]
References
Further reading
- Sladek FM, Darnell JE (1992). "Mechanisms of liver-specific gene expression". Curr. Opin. Genet. Dev. 2 (2): 256–9. PMID 1638120.
- Gombart AF, Koeffler HP (2002). "Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon)". Curr. Opin. Hematol. 9 (1): 36–42. PMID 11753076.
- Williams SC, Cantwell CA, Johnson PF (1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes Dev. 5 (9): 1553–67. PMID 1884998.
- Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics. 35 (1): 30–8. PMID 8661101.
- Chumakov AM, Grillier I, Chumakova E; et al. (1997). "Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor". Mol. Cell. Biol. 17 (3): 1375–86. PMID 9032264.
- Yamanaka R, Kim GD, Radomska HS; et al. (1997). "CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing". Proc. Natl. Acad. Sci. U.S.A. 94 (12): 6462–7. PMID 9177240.
- Verbeek W, Gombart AF, Chumakov AM; et al. (1999). "C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters". Blood. 93 (10): 3327–37. PMID 10233885.
- Lekstrom-Himes JA, Dorman SE, Kopar P; et al. (1999). "Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon". J. Exp. Med. 189 (11): 1847–52. PMID 10359588.
- Tavor S, Vuong PT, Park DJ; et al. (2002). "Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice". Blood. 99 (5): 1794–801. PMID 11861297.
- Zhang P, Nelson E, Radomska HS; et al. (2002). "Induction of granulocytic differentiation by 2 pathways". Blood. 99 (12): 4406–12. PMID 12036869.
- Kim J, Cantwell CA, Johnson PF; et al. (2002). "Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation". J. Biol. Chem. 277 (41): 38037–44. doi:10.1074/jbc.M207235200. PMID 12161447.
- Du J, Stankiewicz MJ, Liu Y; et al. (2003). "Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein". J. Biol. Chem. 277 (45): 43481–94. doi:10.1074/jbc.M204777200. PMID 12202480.
- Truong BT, Lee YJ, Lodie TA; et al. (2003). "CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia". Blood. 101 (3): 1141–8. doi:10.1182/blood-2002-05-1374. PMID 12393450.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Gombart AF, Kwok SH, Anderson KL; et al. (2003). "Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1". Blood. 101 (8): 3265–73. doi:10.1182/blood-2002-04-1039. PMID 12515729.
- Khanna-Gupta A, Zibello T, Sun H; et al. (2003). "Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBP alpha and C/EBP epsilon ) and CDP/cut in myeloid maturation-induced lactoferrin gene expression". Blood. 101 (9): 3460–8. doi:10.1182/blood-2002-09-2767. PMID 12522000.
- Gery S, Gombart AF, Fung YK, Koeffler HP (2004). "C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis". Blood. 103 (3): 828–35. doi:10.1182/blood-2003-01-0159. PMID 12947005.
- Gery S, Park DJ, Vuong PT; et al. (2005). "Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes". Blood. 104 (13): 3911–7. doi:10.1182/blood-2003-10-3688. PMID 15308577.
External links
- CEBPE+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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