Autoimmune lymphoproliferative syndrome history and symptoms: Difference between revisions
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'''Editor-In-Chief:''' David Teachey, MD [mailto:TEACHEYD@email.chop.edu] | '''Editor-In-Chief:''' David Teachey, MD [mailto:TEACHEYD@email.chop.edu] | ||
==Overview== | ==Overview== | ||
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==History and Symptoms== | ==History and Symptoms== | ||
Common [[symptoms]] include: | |||
* [[Fatigue]]<ref name="Rieux-LaucatMagérus-Chatinet2018">{{cite journal|last1=Rieux-Laucat|first1=Frédéric|last2=Magérus-Chatinet|first2=Aude|last3=Neven|first3=Bénédicte|title=The Autoimmune Lymphoproliferative Syndrome with Defective FAS or FAS-Ligand Functions|journal=Journal of Clinical Immunology|volume=38|issue=5|year=2018|pages=558–568|issn=0271-9142|doi=10.1007/s10875-018-0523-x}}</ref> | * [[Fatigue]]<ref name="Rieux-LaucatMagérus-Chatinet2018">{{cite journal|last1=Rieux-Laucat|first1=Frédéric|last2=Magérus-Chatinet|first2=Aude|last3=Neven|first3=Bénédicte|title=The Autoimmune Lymphoproliferative Syndrome with Defective FAS or FAS-Ligand Functions|journal=Journal of Clinical Immunology|volume=38|issue=5|year=2018|pages=558–568|issn=0271-9142|doi=10.1007/s10875-018-0523-x}}</ref> | ||
* Recurrent [[infections]] - due to [[neutropenia]]<ref name="MatsonYang2019">{{cite journal|last1=Matson|first1=Daniel R.|last2=Yang|first2=David T.|title=Autoimmune Lymphoproliferative Syndrome: An Overview|journal=Archives of Pathology & Laboratory Medicine|volume=144|issue=2|year=2019|pages=245–251|issn=0003-9985|doi=10.5858/arpa.2018-0190-RS}}</ref> | * Recurrent [[infections]] - due to [[neutropenia]]<ref name="MatsonYang2019">{{cite journal|last1=Matson|first1=Daniel R.|last2=Yang|first2=David T.|title=Autoimmune Lymphoproliferative Syndrome: An Overview|journal=Archives of Pathology & Laboratory Medicine|volume=144|issue=2|year=2019|pages=245–251|issn=0003-9985|doi=10.5858/arpa.2018-0190-RS}}</ref> | ||
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==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
Revision as of 02:38, 6 July 2021
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Editor-In-Chief: David Teachey, MD [1]
Overview
Autoimmune lymphoproliferative syndrome (ALPS) hard to diagnose due to expressions of different phenotypes and overlapping symptoms with other hematological disorders. The most common symptoms of ALPS are related to lymphadenopathy predominantly in cervical region, splenomegaly with or without features of hypersplenism or hepatomegaly, and autoimmune cytopenias as thrombocytopenia, hemolytic anemia or occasional neutropenia. Autoimmune cytopenia and lymphoproliferation occur simultaneously in most cases but can also happen separately or in an interval.
History and Symptoms
Common symptoms include:
- Fatigue[1]
- Recurrent infections - due to neutropenia[2]
- Abdominal pain
- Bruising
- Excessive bleeding
References
- ↑ Rieux-Laucat, Frédéric; Magérus-Chatinet, Aude; Neven, Bénédicte (2018). "The Autoimmune Lymphoproliferative Syndrome with Defective FAS or FAS-Ligand Functions". Journal of Clinical Immunology. 38 (5): 558–568. doi:10.1007/s10875-018-0523-x. ISSN 0271-9142.
- ↑ Matson, Daniel R.; Yang, David T. (2019). "Autoimmune Lymphoproliferative Syndrome: An Overview". Archives of Pathology & Laboratory Medicine. 144 (2): 245–251. doi:10.5858/arpa.2018-0190-RS. ISSN 0003-9985.