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==Natural History==
==Natural History==
===Asthma in Children===
===Asthma in Children===
Many children often develop one or more episodes of wheezing early in life. These episodes are often associated with respiratory viral infection<ref name="pmid17353039">{{cite journal| author=Kusel MM, de Klerk NH, Kebadze T, Vohma V, Holt PG, Johnston SL et al.| title=Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. | journal=J Allergy Clin Immunol | year= 2007 | volume= 119 | issue= 5 | pages= 1105-10 | pmid=17353039 | doi=10.1016/j.jaci.2006.12.669 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17353039  }} </ref>. '''Tucson Children's Respiratory Study'''which is a longitudinal birth cohort study also demonstrated that the prevalence of wheezing in presence of lower respiratory tract illness was 32%, 17% and 12% at first, second and third year of life, respectively<ref name="pmid12704342">{{cite journal| author=Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD| title=Tucson Children's Respiratory Study: 1980 to present. | journal=J Allergy Clin Immunol | year= 2003 | volume= 111 | issue= 4 | pages= 661-75; quiz 676 | pmid=12704342 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12704342  }} </ref>. [[Respiratory syncytial virus]] (RSV) followed by [[parainfluenza virus]] type 3 are the common causative agents identified<ref name="pmid448557">{{cite journal| author=Henderson FW, Clyde WA, Collier AM, Denny FW, Senior RJ, Sheaffer CI et al.| title=The etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice. | journal=J Pediatr | year= 1979 | volume= 95 | issue= 2 | pages= 183-90 | pmid=448557 | doi= | pmc= | url= }} </ref><ref name="pmid3009769">{{cite journal| author=Denny FW, Clyde WA| title=Acute lower respiratory tract infections in nonhospitalized children. | journal=J Pediatr | year= 1986 | volume= 108 | issue= 5 Pt 1 | pages= 635-46 | pmid=3009769 | doi= | pmc= | url= }} </ref><ref name="pmid12704342">{{cite journal| author=Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD| title=Tucson Children's Respiratory Study: 1980 to present. | journal=J Allergy Clin Immunol | year= 2003 | volume= 111 | issue= 4 | pages= 661-75; quiz 676 | pmid=12704342 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12704342  }} </ref>. At age of 6 years, 20% of children who had previous episodes of lower respiratory illness with wheezing during the first three years of life, had no wheezing, 13.7% of children who had wheezing before three years of age continued to have wheezing. 15% of children were reported to have new onset wheezing at 6 years of age. Majority of children with wheeze were associated with transient conditions such as viral illness which do not increase the risk  of asthma later in life<ref name="pmid7800004">{{cite journal| author=Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ| title=Asthma and wheezing in the first six years of life. The Group Health Medical Associates. | journal=N Engl J Med | year= 1995 | volume= 332 | issue= 3 | pages= 133-8 | pmid=7800004 | doi=10.1056/NEJM199501193320301 | pmc= | url= }} </ref>. Lung function values among children with persistent wheezing were not different from those who never wheezed. However, their IgE levels were elevated<ref name="pmid12704342">{{cite journal| author=Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD| title=Tucson Children's Respiratory Study: 1980 to present. | journal=J Allergy Clin Immunol | year= 2003 | volume= 111 | issue= 4 | pages= 661-75; quiz 676 | pmid=12704342 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12704342  }} </ref> suggesting allergic/asthma predisposition. The late-onset wheezing and the persistent wheezing groups had more episodes of wheezing in late childhood and adolescence<ref name="pmid8765817">{{cite journal| author=Dodge R, Martinez FD, Cline MG, Lebowitz MD, Burrows B| title=Early childhood respiratory symptoms and the subsequent diagnosis of asthma. | journal=J Allergy Clin Immunol | year= 1996 | volume= 98 | issue= 1 | pages= 48-54 | pmid=8765817 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8765817  }} </ref>.
*Many children often develop one or more episodes of wheezing early in life. These episodes are often associated with respiratory viral infection<ref name="pmid17353039">{{cite journal| author=Kusel MM, de Klerk NH, Kebadze T, Vohma V, Holt PG, Johnston SL et al.| title=Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. | journal=J Allergy Clin Immunol | year= 2007 | volume= 119 | issue= 5 | pages= 1105-10 | pmid=17353039 | doi=10.1016/j.jaci.2006.12.669 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17353039  }} </ref>. '''Tucson Children's Respiratory Study'''which is a longitudinal birth cohort study also demonstrated that the prevalence of wheezing in presence of lower respiratory tract illness was 32%, 17% and 12% at first, second and third year of life, respectively<ref name="pmid12704342">{{cite journal| author=Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD| title=Tucson Children's Respiratory Study: 1980 to present. | journal=J Allergy Clin Immunol | year= 2003 | volume= 111 | issue= 4 | pages= 661-75; quiz 676 | pmid=12704342 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12704342  }} </ref>. [[Respiratory syncytial virus]] (RSV) followed by [[parainfluenza virus]] type 3 are the common causative agents identified<ref name="pmid448557">{{cite journal| author=Henderson FW, Clyde WA, Collier AM, Denny FW, Senior RJ, Sheaffer CI et al.| title=The etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice. | journal=J Pediatr | year= 1979 | volume= 95 | issue= 2 | pages= 183-90 | pmid=448557 | doi= | pmc= | url= }} </ref><ref name="pmid3009769">{{cite journal| author=Denny FW, Clyde WA| title=Acute lower respiratory tract infections in nonhospitalized children. | journal=J Pediatr | year= 1986 | volume= 108 | issue= 5 Pt 1 | pages= 635-46 | pmid=3009769 | doi= | pmc= | url= }} </ref><ref name="pmid12704342">{{cite journal| author=Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD| title=Tucson Children's Respiratory Study: 1980 to present. | journal=J Allergy Clin Immunol | year= 2003 | volume= 111 | issue= 4 | pages= 661-75; quiz 676 | pmid=12704342 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12704342  }} </ref>. At age of 6 years, 20% of children who had previous episodes of lower respiratory illness with wheezing during the first three years of life, had no wheezing, 13.7% of children who had wheezing before three years of age continued to have wheezing. 15% of children were reported to have new onset wheezing at 6 years of age. Majority of children with wheeze were associated with transient conditions such as viral illness which do not increase the risk  of asthma later in life<ref name="pmid7800004">{{cite journal| author=Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ| title=Asthma and wheezing in the first six years of life. The Group Health Medical Associates. | journal=N Engl J Med | year= 1995 | volume= 332 | issue= 3 | pages= 133-8 | pmid=7800004 | doi=10.1056/NEJM199501193320301 | pmc= | url= }} </ref>. Lung function values among children with persistent wheezing were not different from those who never wheezed. However, their IgE levels were elevated<ref name="pmid12704342">{{cite journal| author=Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD| title=Tucson Children's Respiratory Study: 1980 to present. | journal=J Allergy Clin Immunol | year= 2003 | volume= 111 | issue= 4 | pages= 661-75; quiz 676 | pmid=12704342 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12704342  }} </ref> suggesting allergic/asthma predisposition. The late-onset wheezing and the persistent wheezing groups had more episodes of wheezing in late childhood and adolescence<ref name="pmid8765817">{{cite journal| author=Dodge R, Martinez FD, Cline MG, Lebowitz MD, Burrows B| title=Early childhood respiratory symptoms and the subsequent diagnosis of asthma. | journal=J Allergy Clin Immunol | year= 1996 | volume= 98 | issue= 1 | pages= 48-54 | pmid=8765817 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8765817  }} </ref>.


'''The Melbourne Asthma Study''' which is a longitudinal community based study (1964-1999), is considered to reflect the natural course of asthma from childhood (7 years of age) into adult life (42 years of age) as the patients were not optimally treated according to present guidelines. The study demonstrated that the children with few episodes of wheezing associated with respiratory infection had a benign course, with many becoming asymptomatic by adult life. While, those with severe asthma during childhood continued to be symptomatic during adulthood and there was a progressive loss in pulmonary function noted as the patients approached 14 years of age but did not progress in adult life. Loss of lung function was not noted in patients with milder symptoms<ref name="pmid11842286">{{cite journal| author=Phelan PD, Robertson CF, Olinsky A| title=The Melbourne Asthma Study: 1964-1999. | journal=J Allergy Clin Immunol | year= 2002 | volume= 109 | issue= 2 | pages= 189-94 | pmid=11842286 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11842286  }} </ref>.
*'''The Melbourne Asthma Study''' which is a longitudinal community based study (1964-1999), is considered to reflect the natural course of asthma from childhood (7 years of age) into adult life (42 years of age) as the patients were not optimally treated according to present guidelines. The study demonstrated that the children with few episodes of wheezing associated with respiratory infection had a benign course, with many becoming asymptomatic by adult life. While, those with severe asthma during childhood continued to be symptomatic during adulthood and there was a progressive loss in pulmonary function noted as the patients approached 14 years of age but did not progress in adult life. Loss of lung function was not noted in patients with milder symptoms<ref name="pmid11842286">{{cite journal| author=Phelan PD, Robertson CF, Olinsky A| title=The Melbourne Asthma Study: 1964-1999. | journal=J Allergy Clin Immunol | year= 2002 | volume= 109 | issue= 2 | pages= 189-94 | pmid=11842286 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11842286 }} </ref>.
 
*In another birth cohort study in Dunedin, New Zealand 613 children were followed every 2 years between 3 and 15 years of age and then at 18, 21, and 26 years of age<ref name="pmid3449120">{{cite journal| author=Jones DT, Sears MR, Holdaway MD, Hewitt CJ, Flannery EM, Herbison GP et al.| title=Childhood asthma in New Zealand. | journal=Br J Dis Chest | year= 1987 | volume= 81 | issue= 4 | pages= 332-40 | pmid=3449120 | doi= | pmc= | url= }} </ref>. By 26 years of age, approximately 50% of the cohort had reported wheezing at least once. Bronchodilator response (or a positive methacholine test) and a positive skin test result to mite or cat at 9 years of age, predicted the persistence of asthma at 26 years of age<ref name="pmid14534334">{{cite journal| author=Sears MR, Greene JM, Willan AR, Wiecek EM, Taylor DR, Flannery EM et al.| title=A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. | journal=N Engl J Med | year= 2003 | volume= 349 | issue= 15 | pages= 1414-22 | pmid=14534334 | doi=10.1056/NEJMoa022363 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14534334  }} </ref>.
 
*Similar to above mentioned studies, the Childhood Asthma Management Program ('''CAMP''') also reported decline in pulmonary function with age if the onset of asthma is early in childhood. Significant correlation between duration of asthma and decline in lung function, greater [[methacholine challenge test|methacholine responsiveness]], more asthma symptoms, and greater use of as-needed [[albuterol]] was noted from the baseline data of 1041 children. In addition it also reported that independent of baseline lung function, the airway responsiveness increased after puberty in girls, but decreased after puberty in boys<ref name="pmid17088127">{{cite journal| author=Strunk RC, Weiss ST, Yates KP, Tonascia J, Zeiger RS, Szefler SJ et al.| title=Mild to moderate asthma affects lung growth in children and adolescents. | journal=J Allergy Clin Immunol | year= 2006 | volume= 118 | issue= 5 | pages= 1040-7 | pmid=17088127 | doi=10.1016/j.jaci.2006.07.053 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17088127 }} </ref>.


==Prognosis==
==Prognosis==
Line 13: Line 17:
For those who continue to suffer from mild symptoms, corticosteroids can help most to live their lives with few disabilities. The mortality rate for asthma is low, with around 6000 deaths per year in a population of some 10 million patients in the United States. Better control of the condition may help prevent some of these deaths.
For those who continue to suffer from mild symptoms, corticosteroids can help most to live their lives with few disabilities. The mortality rate for asthma is low, with around 6000 deaths per year in a population of some 10 million patients in the United States. Better control of the condition may help prevent some of these deaths.


In a birth cohort study in Dunedin, New Zealand, bronchodilator response (or a positive methacholine test) and a positive skin test result to mite or cat at 9 years of age, predicted the persistence of asthma at 26 years of age<ref name="pmid14534334">{{cite journal| author=Sears MR, Greene JM, Willan AR, Wiecek EM, Taylor DR, Flannery EM et al.| title=A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. | journal=N Engl J Med | year= 2003 | volume= 349 | issue= 15 | pages= 1414-22 | pmid=14534334 | doi=10.1056/NEJMoa022363 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14534334  }} </ref>.
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Revision as of 15:33, 22 September 2011

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Editor(s)-in-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753; Philip Marcus, M.D., M.P.H. [2]; Associate Editor(s)-In-Chief: Varun Kumar, M.B.B.S. [3]

Natural History

Asthma in Children

  • Many children often develop one or more episodes of wheezing early in life. These episodes are often associated with respiratory viral infection[1]. Tucson Children's Respiratory Studywhich is a longitudinal birth cohort study also demonstrated that the prevalence of wheezing in presence of lower respiratory tract illness was 32%, 17% and 12% at first, second and third year of life, respectively[2]. Respiratory syncytial virus (RSV) followed by parainfluenza virus type 3 are the common causative agents identified[3][4][2]. At age of 6 years, 20% of children who had previous episodes of lower respiratory illness with wheezing during the first three years of life, had no wheezing, 13.7% of children who had wheezing before three years of age continued to have wheezing. 15% of children were reported to have new onset wheezing at 6 years of age. Majority of children with wheeze were associated with transient conditions such as viral illness which do not increase the risk of asthma later in life[5]. Lung function values among children with persistent wheezing were not different from those who never wheezed. However, their IgE levels were elevated[2] suggesting allergic/asthma predisposition. The late-onset wheezing and the persistent wheezing groups had more episodes of wheezing in late childhood and adolescence[6].
  • The Melbourne Asthma Study which is a longitudinal community based study (1964-1999), is considered to reflect the natural course of asthma from childhood (7 years of age) into adult life (42 years of age) as the patients were not optimally treated according to present guidelines. The study demonstrated that the children with few episodes of wheezing associated with respiratory infection had a benign course, with many becoming asymptomatic by adult life. While, those with severe asthma during childhood continued to be symptomatic during adulthood and there was a progressive loss in pulmonary function noted as the patients approached 14 years of age but did not progress in adult life. Loss of lung function was not noted in patients with milder symptoms[7].
  • In another birth cohort study in Dunedin, New Zealand 613 children were followed every 2 years between 3 and 15 years of age and then at 18, 21, and 26 years of age[8]. By 26 years of age, approximately 50% of the cohort had reported wheezing at least once. Bronchodilator response (or a positive methacholine test) and a positive skin test result to mite or cat at 9 years of age, predicted the persistence of asthma at 26 years of age[9].
  • Similar to above mentioned studies, the Childhood Asthma Management Program (CAMP) also reported decline in pulmonary function with age if the onset of asthma is early in childhood. Significant correlation between duration of asthma and decline in lung function, greater methacholine responsiveness, more asthma symptoms, and greater use of as-needed albuterol was noted from the baseline data of 1041 children. In addition it also reported that independent of baseline lung function, the airway responsiveness increased after puberty in girls, but decreased after puberty in boys[10].

Prognosis

The prognosis for asthmatics is good; especially for children with mild disease. For asthmatics diagnosed during childhood, 54% will no longer carry the diagnosis after a decade. The extent of permanent lung damage in asthmatics is unclear. Airway remodelling is observed, but it is unknown whether these represent harmful or beneficial changes.[11] Although conclusions from studies are mixed, most studies show that early treatment with glucocorticoids prevents or ameliorates decline in lung function as measured by several parameters.[12] For those who continue to suffer from mild symptoms, corticosteroids can help most to live their lives with few disabilities. The mortality rate for asthma is low, with around 6000 deaths per year in a population of some 10 million patients in the United States. Better control of the condition may help prevent some of these deaths.

In a birth cohort study in Dunedin, New Zealand, bronchodilator response (or a positive methacholine test) and a positive skin test result to mite or cat at 9 years of age, predicted the persistence of asthma at 26 years of age[9].

References

  1. Kusel MM, de Klerk NH, Kebadze T, Vohma V, Holt PG, Johnston SL; et al. (2007). "Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma". J Allergy Clin Immunol. 119 (5): 1105–10. doi:10.1016/j.jaci.2006.12.669. PMID 17353039.
  2. 2.0 2.1 2.2 Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD (2003). "Tucson Children's Respiratory Study: 1980 to present". J Allergy Clin Immunol. 111 (4): 661–75, quiz 676. PMID 12704342.
  3. Henderson FW, Clyde WA, Collier AM, Denny FW, Senior RJ, Sheaffer CI; et al. (1979). "The etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice". J Pediatr. 95 (2): 183–90. PMID 448557.
  4. Denny FW, Clyde WA (1986). "Acute lower respiratory tract infections in nonhospitalized children". J Pediatr. 108 (5 Pt 1): 635–46. PMID 3009769.
  5. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ (1995). "Asthma and wheezing in the first six years of life. The Group Health Medical Associates". N Engl J Med. 332 (3): 133–8. doi:10.1056/NEJM199501193320301. PMID 7800004.
  6. Dodge R, Martinez FD, Cline MG, Lebowitz MD, Burrows B (1996). "Early childhood respiratory symptoms and the subsequent diagnosis of asthma". J Allergy Clin Immunol. 98 (1): 48–54. PMID 8765817.
  7. Phelan PD, Robertson CF, Olinsky A (2002). "The Melbourne Asthma Study: 1964-1999". J Allergy Clin Immunol. 109 (2): 189–94. PMID 11842286.
  8. Jones DT, Sears MR, Holdaway MD, Hewitt CJ, Flannery EM, Herbison GP; et al. (1987). "Childhood asthma in New Zealand". Br J Dis Chest. 81 (4): 332–40. PMID 3449120.
  9. 9.0 9.1 Sears MR, Greene JM, Willan AR, Wiecek EM, Taylor DR, Flannery EM; et al. (2003). "A longitudinal, population-based, cohort study of childhood asthma followed to adulthood". N Engl J Med. 349 (15): 1414–22. doi:10.1056/NEJMoa022363. PMID 14534334.
  10. Strunk RC, Weiss ST, Yates KP, Tonascia J, Zeiger RS, Szefler SJ; et al. (2006). "Mild to moderate asthma affects lung growth in children and adolescents". J Allergy Clin Immunol. 118 (5): 1040–7. doi:10.1016/j.jaci.2006.07.053. PMID 17088127.
  11. Maddox L, Schwartz DA (2002) The pathophysiology of asthma. Annu Rev Med 53 ():477-98. DOI:10.1146/annurev.med.53.082901.103921 PMID: 11818486
  12. Beckett PA, Howarth PH. Pharmacotherapy and airway remodelling in asthma? Thorax. 2003;58(2):163-74. PMID 12554904

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