Asthma exhaled nitric oxide
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S. [2]
Overview
Measurement of fractional nitric oxide concentration in exhaled breath (FeNO)is a non-invasive method of assessing underlying airway inflammation.[1][2] However, due to technical complexities associated with the procedure, it is not routinely used.[3]
Exhaled Nitric Oxide Breath Test
- Asthma is a chronic inflammatory disease with hyper-responsive airways. As a part of the inflammatory process, there is an associated up-regulation in the nitric oxide synthase observed in the respiratory mucosal epithelium, which contributes to the increased concentrations of nitric oxide released in exhaled breath.
References
- ↑ Silkoff PE, Carlson M, Bourke T, Katial R, Ogren E, Szefler SJ (2004) The Aerocrine exhaled nitric oxide monitoring system NIOX is cleared by the US Food and Drug Administration for monitoring therapy in asthma. J Allergy Clin Immunol 114 (5):1241-56. DOI:10.1016/j.jaci.2004.08.042 PMID: 15536442
- ↑ Sippel JM, Holden WE, Tilles SA, O'Hollaren M, Cook J, Thukkani N et al. (2000) Exhaled nitric oxide levels correlate with measures of disease control in asthma. J Allergy Clin Immunol 106 (4):645-50. DOI:10.1067/mai.2000.109618 PMID: 11031334
- ↑ Bates CA, Silkoff PE (2003) Exhaled nitric oxide in asthma: from bench to bedside. J Allergy Clin Immunol 111 (2):256-62. PMID: 12589342