Aplastic anemia laboratory findings

Aplastic anemia Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Aplastic anemia from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Aplastic anemia laboratory findings On the Web
Most recent articles
cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Aplastic anemia laboratory findings All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Aplastic anemia laboratory findings
CDC on Aplastic anemia laboratory findings
Aplastic anemia laboratory findings in the news
Blogs on Aplastic anemia laboratory findings
Directions to Hospitals Treating Aplastic anemia
Risk calculators and risk factors for Aplastic anemia laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2]

Overview

Patients with aplastic anemia have a hypoplastic bone marrow (<20% cellularity), pancytopenia (transfusion-dependent anemia, thrombocytopenia, and severe neutropenia), a low reticulocyte count, and with normal maturation of all cell lines.

Laboratory Findings

Complete Blood Count

• Decreased hemoglobin
• Decreased hematocrit
• Pancytopenia (anemia, thrombocytopenia, and severe neutropenia)
• Mean corpuscular volume

Reticulocyte Count

• Low reticulocyte levels.

Bone Marrow Tests (Aspiration and biopsy)

• Bone marrow aspiration might be done to find out if and why bone marrow isn't making enough blood cells. For this test, a small amount of bone marrow fluid is aspirated through a needle. The sample is looked at under a microscope to check for faulty cells.
• A bone marrow biopsy might be done at the same time as an aspiration or afterward. For this test, your doctor removes a small amount of bone marrow tissue through a needle. The tissue is checked for the number and types of cells in the bone marrow. In aplastic anemia, the bone marrow has a lower than normal number of all three types of blood cells.
• Bone marrow biopsy (hypoplastic bone marrow (<20% cellularity), and with normal maturation of all cell lines.

Other tests

• Renal function
• Basic metabolic panel
• Liver enzymes
• Thyroid function tests
• Viral studies
• vitamin B12 and folic acid levels.