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(/* Diagnosis and management of aplastic anemia {{cite journal| author=Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC et al.| title=Guidelines for the diagnosis and management of aplastic anaemia. | journal=Br J Haematol | ye...) |
(/* Diagnosis and management of aplastic anemia {{cite journal| author=Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC et al.| title=Guidelines for the diagnosis and management of aplastic anaemia. | journal=Br J Haematol | ye...) |
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===Diagnosis and Evaluation of aplastic anemia=== | ===Diagnosis and Evaluation of aplastic anemia=== | ||
* Careful history and clinical examination | |||
* Detailed drug and occupational exposure history | |||
Careful history and clinical examination | * Patients presenting with aplastic anaemia should be assessed to: | ||
Detailed drug and occupational exposure history | ** Confirm the diagnosis and exclude other possible causes of pancytopenia with hypocellular bone marrow | ||
Patients presenting with aplastic anaemia should be assessed to: | ** Classify the disease severity using standard blood and bone marrow criteria | ||
Confirm the diagnosis and exclude other possible causes of pancytopenia with hypocellular bone marrow | ** Document the presence of associated paroxysmal nocturnal haemoglobinuria (PNH) and cytogenetic clones | ||
Classify the disease severity using standard blood and bone marrow criteria | ** Exclude a possible late onset inherited bone marrow failure disorder | ||
Document the presence of associated paroxysmal nocturnal haemoglobinuria (PNH) and cytogenetic clones | * Multidisciplinary approach | ||
Exclude a possible late onset inherited bone marrow failure disorder | * Referral to specialist if necessary | ||
Multidisciplinary approach | |||
Referral to specialist if necessary | |||
}} | }} | ||
Revision as of 14:26, 23 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Aplastic anemia is seen as a result of hypoplastic bone marrow causing pancytopenia (anemia, neutropenia, thrombocytopenia). The history and symptoms seen are secondary to these abnormalities.
Symptoms
- Malaise, fatigue, and pallor (Anemia)
- Increased risk of hemorrhage, bruising, and menorrhagia (thrombocytopenia).
- Increased risk of infection (leukopenia)
Diagnosis and management of aplastic anemia [1] (DONOT EDIT)
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Diagnosis and Evaluation of aplastic anemia
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References
- ↑ Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC; et al. (2009). "Guidelines for the diagnosis and management of aplastic anaemia". Br J Haematol. 147 (1): 43–70. doi:10.1111/j.1365-2141.2009.07842.x. PMID 19673883.