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__NOTOC__
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{{Anaphylaxis}}
{{Anaphylaxis}}
{{CMG}}, {{AE}} [[User:Dushka|Dushka Riaz, MD]]


{{CMG}}
==Overview==
Common complications of [[anaphylaxis]] include [[airway]] blockage, [[cardiac arrest]], [[respiratory arrest]], and [[shock]]. [[Prognosis]] is generally good with prompt [[diagnosis]] and [[treatment]]. It is important to follow up with an [[allergist]] to determine the exact cause of the [[anaphylaxis]] and advise the patient to avoid it in the future. <ref name="pmid25577624">{{cite journal| author=Campbell RL, Park MA, Kueber MA, Lee S, Hagan JB| title=Outcomes of allergy/immunology follow-up after an emergency department evaluation for anaphylaxis. | journal=J Allergy Clin Immunol Pract | year= 2015 | volume= 3 | issue= 1 | pages= 88-93 | pmid=25577624 | doi=10.1016/j.jaip.2014.07.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25577624  }} </ref> The main cause of [[mortality]] is [[Cardiovascular disease|cardiovascular]] compromise or [[Airway obstruction|airway]] compromise and is more common in patients with [[asthma]]. <ref name="pmid28800865">{{cite journal| author=LoVerde D, Iweala OI, Eginli A, Krishnaswamy G| title=Anaphylaxis. | journal=Chest | year= 2018 | volume= 153 | issue= 2 | pages= 528-543 | pmid=28800865 | doi=10.1016/j.chest.2017.07.033 | pmc=6026262 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28800865  }} </ref>
 
==Natural History, Complications, and Prognosis==
 
===Natural History===


==Overview==
*The [[symptoms]] of [[anaphylaxis]] usually develop within seconds with rapid evolution. It usually carries an unpredictable course and can resolve as quickly as it began. If left untreated, [[anaphylaxis]] can progress to [[respiratory]] or [[cardiovascular]] compromise.  <ref name="pmid10931122">{{cite journal| author=Pumphrey RS| title=Lessons for management of anaphylaxis from a study of fatal reactions. | journal=Clin Exp Allergy | year= 2000 | volume= 30 | issue= 8 | pages= 1144-50 | pmid=10931122 | doi=10.1046/j.1365-2222.2000.00864.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10931122  }} </ref> <ref name="pmid16461138">{{cite journal| author=Simons FE| title=Anaphylaxis, killer allergy: long-term management in the community. | journal=J Allergy Clin Immunol | year= 2006 | volume= 117 | issue= 2 | pages= 367-77 | pmid=16461138 | doi=10.1016/j.jaci.2005.12.002 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16461138  }} </ref>


==Complications==
===Complications===


Possible complications include:
Possible [[complications]] include: <ref name="pmid29489197">{{cite journal| author=| title=StatPearls | journal= | year= 2021 | volume=  | issue=  | pages=  | pmid=29489197 | doi= | pmc= | url= }} </ref>


*Airway blockage
*[[Airway blockage]]
*[[Cardiac arrest]] (no effective heartbeat)
*[[Cardiac arrest]] (no effective heartbeat)
*[[Respiratory arrest]] (no breathing)
*[[Respiratory arrest]] (no breathing)
*[[Shock]]
*[[Shock]]


==Prognosis==
===Prognosis===


Anaphylaxis is a severe disorder that can be life-threatening without prompt treatment. However, symptoms usually get better with the right therapy, so it is important to act right away.
[[Anaphylaxis]] can be fatal without prompt [[treatment]]. [[Symptom|symptoms]] generally resolve quickly with prompt treatment. Depending on the availability of [[Epinephrine (patient information)|epinephrine]] treatment, the [[prognosis]] may vary. <ref name="pmid29489197">{{cite journal| author=| title=StatPearls | journal= | year= 2021 | volume=  | issue=  | pages=  | pmid=29489197 | doi= | pmc= | url= }} </ref>


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
{{WH}}
{{WS}}
[[CME Category::Cardiology]]
[[Category:Emergency medicine]]
[[Category:Cardiology]]
[[Category:Allergology]]
[[Category:Pulmonology]]
[[Category:Immunology]]
[[Category:Needs content]]
[[Category:Needs overview]]

Latest revision as of 09:38, 15 April 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Dushka Riaz, MD

Overview

Common complications of anaphylaxis include airway blockage, cardiac arrest, respiratory arrest, and shock. Prognosis is generally good with prompt diagnosis and treatment. It is important to follow up with an allergist to determine the exact cause of the anaphylaxis and advise the patient to avoid it in the future. [1] The main cause of mortality is cardiovascular compromise or airway compromise and is more common in patients with asthma. [2]

Natural History, Complications, and Prognosis

Natural History

Complications

Possible complications include: [5]

Prognosis

Anaphylaxis can be fatal without prompt treatment. symptoms generally resolve quickly with prompt treatment. Depending on the availability of epinephrine treatment, the prognosis may vary. [5]

References

  1. ↑ Campbell RL, Park MA, Kueber MA, Lee S, Hagan JB (2015). "Outcomes of allergy/immunology follow-up after an emergency department evaluation for anaphylaxis". J Allergy Clin Immunol Pract. 3 (1): 88–93. doi:10.1016/j.jaip.2014.07.011. PMID 25577624.
  2. ↑ LoVerde D, Iweala OI, Eginli A, Krishnaswamy G (2018). "Anaphylaxis". Chest. 153 (2): 528–543. doi:10.1016/j.chest.2017.07.033. PMC 6026262. PMID 28800865.
  3. ↑ Pumphrey RS (2000). "Lessons for management of anaphylaxis from a study of fatal reactions". Clin Exp Allergy. 30 (8): 1144–50. doi:10.1046/j.1365-2222.2000.00864.x. PMID 10931122.
  4. ↑ Simons FE (2006). "Anaphylaxis, killer allergy: long-term management in the community". J Allergy Clin Immunol. 117 (2): 367–77. doi:10.1016/j.jaci.2005.12.002. PMID 16461138.
  5. ↑ 5.0 5.1 "StatPearls". 2021. PMID 29489197.

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