Anaphylaxis classification: Difference between revisions

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Revision as of 21:06, 5 February 2013

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-==Classification==
-Anaphylactic shock, the most severe type of anaphylaxis, occurs when an allergic response triggers a quick release from [[mast cell]]s of large quantities of [[immunology|immunological]] mediators ([[histamine]]s, [[prostaglandin]]s, [[leukotriene]]s) leading to systemic [[vasodilation]] (associated with a sudden drop in blood pressure) and [[edema]] of [[bronchial]] [[mucosa]] (resulting in [[bronchoconstriction]] and difficulty breathing).  Anaphylactic shock can lead to death in a matter of minutes if left untreated.
-Researchers typically distinguish between true anaphylaxis and pseudo-anaphylaxis.  The symptoms, treatment, and risk of death are identical, but "true" anaphylaxis is always caused directly by [[degranulation]] of [[mast cell]]s or basophils that is mediated by [[immunoglobulin]] E (IgE), and pseudo-anaphylaxis occurs due to all other causes.  The distinction is only important for researchers who are studying mechanisms of allergic reactions. Due to the word "pseudo", it may frustrate patients who feel they are being told that a life-threatening allergic reaction isn't "real".
 ==References==
 {{Reflist|2}}
-[[Category:Needs overview]]
+[[Category:Needs content]]
 [[Category:Emergency medicine]]
 [[Category:Cardiology]]