ATP2A3: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Sarcoplasmic/endoplasmic reticulum calcium ATPase 3''' is an [[enzyme]] that in [[human]]s is encoded by the ''ATP2A3'' [[gene]].<ref name="pmid8809064">{{cite journal | vauthors = Dode L, Wuytack F, Kools PF, Baba-Aissa F, Raeymaekers L, Brike F, van de Ven WJ, Casteels R | title = cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca<sup>2+</sup>-ATPase 3 gene | journal = Biochem J | volume = 318 | issue = 2| pages = 689–99 |date=Nov 1996 | pmid = 8809064 | pmc = 1217674 | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATP2A3 ATPase, Ca++ transporting, ubiquitous| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=489| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = ATPase, Ca++ transporting, ubiquitous
| HGNCid = 813
| Symbol = ATP2A3
| AltSymbols =; SERCA3
| OMIM = 601929
| ECnumber = 
| Homologene = 69131
| MGIid = 1194503
| GeneAtlas_image1 = PBB_GE_ATP2A3_207522_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ATP2A3_207521_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_ATP2A3_213036_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0005388 |text = calcium-transporting ATPase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0015662 |text = ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016820 |text = hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016529 |text = sarcoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006812 |text = cation transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0015992 |text = proton transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 489
    | Hs_Ensembl = ENSG00000074370
    | Hs_RefseqProtein = NP_005164
    | Hs_RefseqmRNA = NM_005173
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 3773918
    | Hs_GenLoc_end = 3814485
    | Hs_Uniprot = Q93084
    | Mm_EntrezGene = 53313
    | Mm_Ensembl = ENSMUSG00000020788
    | Mm_RefseqmRNA = NM_016745
    | Mm_RefseqProtein = NP_058025
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 72777450
    | Mm_GenLoc_end = 72809234
    | Mm_Uniprot = Q3U1K2
  }}
}}
'''ATPase, Ca++ transporting, ubiquitous''', also known as '''ATP2A3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ATP2A3 ATPase, Ca++ transporting, ubiquitous| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=489| accessdate = }}</ref>
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: ATP2A3 ATPase, Ca++ transporting, ubiquitous| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=489| accessdate = }}</ref>
| summary_text = This gene encodes one of the SERCA Ca<sup>2+</sup>-ATPases, which are intracellular pumps located in the [[sarcoplasmic reticulum|sarcoplasmic]] or [[endoplasmic reticula]] of cells. SERCA3 expression was originally described as non-muscular, but was recently observed in [[cardiomyocyte]]. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of [[calcium]] from the [[cytosol]] to the sarcoplasmic reticulum [[Lumen (anatomy)|lumen]], and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in 6 transcript variants encoding different isoforms named SERCA3a to SERCA3f.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ATP2A3}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Wuytack F, Papp B, Verboomen H, ''et al.'' |title=A sarco/endoplasmic reticulum Ca(2+)-ATPase 3-type Ca2+ pump is expressed in platelets, in lymphoid cells, and in mast cells. |journal=J. Biol. Chem. |volume=269 |issue= 2 |pages= 1410-6 |year= 1994 |pmid= 8288608 |doi= }}
*{{cite journal | vauthors=Wuytack F, Papp B, Verboomen H |title=A sarco/endoplasmic reticulum Ca<sup>2+</sup>-ATPase 3-type Ca<sup>2+</sup> pump is expressed in platelets, in lymphoid cells, and in mast cells |journal=J. Biol. Chem. |volume=269 |issue= 2 |pages= 1410–6 |year= 1994 |pmid= 8288608 |doi= |display-authors=etal}}
*{{cite journal | author=Dode L, Wuytack F, Kools PF, ''et al.'' |title=cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca(2+)-ATPase 3 gene. |journal=Biochem. J. |volume=318 ( Pt 2) |issue= |pages= 689-99 |year= 1996 |pmid= 8809064 |doi= }}
*{{cite journal | vauthors=Dode L, De Greef C, Mountian I |title=Structure of the human sarco/endoplasmic reticulum Ca<sup>2+</sup>-ATPase 3 gene. Promoter analysis and alternative splicing of the SERCA3 pre-mRNA |journal=J. Biol. Chem. |volume=273 |issue= 22 |pages= 13982–94 |year= 1998 |pmid= 9593748 |doi=10.1074/jbc.273.22.13982 |display-authors=etal}}
*{{cite journal | author=Dode L, De Greef C, Mountian I, ''et al.'' |title=Structure of the human sarco/endoplasmic reticulum Ca2+-ATPase 3 gene. Promoter analysis and alternative splicing of the SERCA3 pre-mRNA. |journal=J. Biol. Chem. |volume=273 |issue= 22 |pages= 13982-94 |year= 1998 |pmid= 9593748 |doi= }}
*{{cite journal | vauthors=Poch E, Leach S, Snape S |title=Functional characterization of alternatively spliced human SERCA3 transcripts |journal=Am. J. Physiol. |volume=275 |issue= 6 Pt 1 |pages= C1449–58 |year= 1999 |pmid= 9843705 |doi= |display-authors=etal}}
*{{cite journal | author=Poch E, Leach S, Snape S, ''et al.'' |title=Functional characterization of alternatively spliced human SERCA3 transcripts. |journal=Am. J. Physiol. |volume=275 |issue= 6 Pt 1 |pages= C1449-58 |year= 1999 |pmid= 9843705 |doi= }}
*{{cite journal | vauthors=Martin V, Bredoux R, Corvazier E |title=Three novel sarco/endoplasmic reticulum Ca<sup>2+</sup>-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24442–52 |year= 2002 |pmid= 11956212 |doi= 10.1074/jbc.M202011200 |display-authors=etal}}
*{{cite journal | author=Martin V, Bredoux R, Corvazier E, ''et al.'' |title=Three novel sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family. |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24442-52 |year= 2002 |pmid= 11956212 |doi= 10.1074/jbc.M202011200 }}
*{{cite journal | vauthors=Gélébart P, Kovács T, Brouland JP |title=Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26310–20 |year= 2002 |pmid= 11986315 |doi= 10.1074/jbc.M201747200 |display-authors=etal}}
*{{cite journal | author=Gélébart P, Kovács T, Brouland JP, ''et al.'' |title=Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26310-20 |year= 2002 |pmid= 11986315 |doi= 10.1074/jbc.M201747200 }}
*{{cite journal | vauthors=Dode L, Vilsen B, Van Baelen K |title=Dissection of the functional differences between sarco(endo)plasmic reticulum Ca<sup>2+</sup>-ATPase (SERCA) 1 and 3 isoforms by steady-state and transient kinetic analyses |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45579–91 |year= 2003 |pmid= 12207029 |doi= 10.1074/jbc.M207778200 |display-authors=etal}}
*{{cite journal | author=Dode L, Vilsen B, Van Baelen K, ''et al.'' |title=Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 3 isoforms by steady-state and transient kinetic analyses. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45579-91 |year= 2003 |pmid= 12207029 |doi= 10.1074/jbc.M207778200 }}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Houston R |title=Longitudinal sections of unfixed muscle |journal=Biotechnic & Histochemistry |volume=77 |issue= 4 |pages= 229–30 |year= 2003 |pmid= 12503734 |doi= }}
*{{cite journal | author=Houston R |title=Longitudinal sections of unfixed muscle. |journal=Biotechnic & histochemistry : official publication of the Biological Stain Commission |volume=77 |issue= 4 |pages= 229-30 |year= 2003 |pmid= 12503734 |doi= }}
*{{cite journal | vauthors=Borge PD, Wolf BA |title=Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11359–68 |year= 2003 |pmid= 12524443 |doi= 10.1074/jbc.M209521200 }}
*{{cite journal | author=Borge PD, Wolf BA |title=Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11359-68 |year= 2003 |pmid= 12524443 |doi= 10.1074/jbc.M209521200 }}
*{{cite journal | vauthors=Chandrasekera CP, Lytton J |title=Inhibition of human SERCA3 by PL/IM430. Molecular analysis of the interaction |journal=J. Biol. Chem. |volume=278 |issue= 14 |pages= 12482–8 |year= 2003 |pmid= 12540840 |doi= 10.1074/jbc.M212745200 }}
*{{cite journal | author=Chandrasekera CP, Lytton J |title=Inhibition of human SERCA3 by PL/IM430. Molecular analysis of the interaction. |journal=J. Biol. Chem. |volume=278 |issue= 14 |pages= 12482-8 |year= 2003 |pmid= 12540840 |doi= 10.1074/jbc.M212745200 }}
*{{cite journal | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal | vauthors=Bobe R, Bredoux R, Corvazier E |title=Identification, expression, function, and localization of a novel (sixth) isoform of the human sarco/endoplasmic reticulum Ca<sup>2+</sup>ATPase 3 gene |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24297–306 |year= 2004 |pmid= 15028735 |doi= 10.1074/jbc.M314286200 |display-authors=etal}}
*{{cite journal | author=Bobe R, Bredoux R, Corvazier E, ''et al.'' |title=Identification, expression, function, and localization of a novel (sixth) isoform of the human sarco/endoplasmic reticulum Ca2+ATPase 3 gene. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24297-306 |year= 2004 |pmid= 15028735 |doi= 10.1074/jbc.M314286200 }}
*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | vauthors=Brouland JP, Gélébart P, Kovàcs T |title=The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis |journal=Am. J. Pathol. |volume=167 |issue= 1 |pages= 233–42 |year= 2005 |pmid= 15972967 |doi= 10.1016/S0002-9440(10)62968-9| pmc=1603437 |display-authors=etal}}
*{{cite journal | author=Brouland JP, Gélébart P, Kovàcs T, ''et al.'' |title=The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis. |journal=Am. J. Pathol. |volume=167 |issue= 1 |pages= 233-42 |year= 2005 |pmid= 15972967 |doi= }}
*{{cite journal | vauthors=Hadri L, Pavoine C, Lipskaia L |title=Transcription of the sarcoplasmic/endoplasmic reticulum Ca<sup>2+</sup>-ATPase type 3 gene, ATP2A3, is regulated by the calcineurin/NFAT pathway in endothelial cells |journal=Biochem. J. |volume=394 |issue= Pt 1 |pages= 27–33 |year= 2006 |pmid= 16250893 |doi= 10.1042/BJ20051387 | pmc=1385999 |display-authors=etal}}
*{{cite journal | author=Hadri L, Pavoine C, Lipskaia L, ''et al.'' |title=Transcription of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase type 3 gene, ATP2A3, is regulated by the calcineurin/NFAT pathway in endothelial cells. |journal=Biochem. J. |volume=394 |issue= Pt 1 |pages= 27-33 |year= 2006 |pmid= 16250893 |doi= 10.1042/BJ20051387 }}
*{{cite journal | vauthors=Wootton LL, Michelangeli F |title=The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca<sup>2+</sup> ATPase (SERCA) Ca<sup>2+</sup> pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors |journal=J. Biol. Chem. |volume=281 |issue= 11 |pages= 6970–6 |year= 2006 |pmid= 16410239 |doi= 10.1074/jbc.M510978200 }}
*{{cite journal | author=Wootton LL, Michelangeli F |title=The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors. |journal=J. Biol. Chem. |volume=281 |issue= 11 |pages= 6970-6 |year= 2006 |pmid= 16410239 |doi= 10.1074/jbc.M510978200 }}
*{{cite journal | vauthors=Chaâbane C, Corvazier E, Bredoux R |title=Sarco/endoplasmic reticulum Ca<sup>2+</sup>ATPase type 3 isoforms (SERCA3b and SERCA3f): distinct roles in cell adhesion and ER stress |journal=Biochem. Biophys. Res. Commun. |volume=345 |issue= 4 |pages= 1377–85 |year= 2006 |pmid= 16725111 |doi= 10.1016/j.bbrc.2006.05.054 |display-authors=etal}}
*{{cite journal | author=Chaâbane C, Corvazier E, Bredoux R, ''et al.'' |title=Sarco/endoplasmic reticulum Ca2+ATPase type 3 isoforms (SERCA3b and SERCA3f): distinct roles in cell adhesion and ER stress. |journal=Biochem. Biophys. Res. Commun. |volume=345 |issue= 4 |pages= 1377-85 |year= 2006 |pmid= 16725111 |doi= 10.1016/j.bbrc.2006.05.054 }}
*{{cite journal | vauthors=Bredoux R, Corvazier E, Dally S |title=Human platelet Ca<sup>2+</sup>-ATPases: new markers of cell differentiation as illustrated in idiopathic scoliosis |journal=Platelets |volume=17 |issue= 6 |pages= 421–33 |year= 2006 |pmid= 16973504 |doi= 10.1080/09537100600758719 |display-authors=etal}}
*{{cite journal | author=Bredoux R, Corvazier E, Dally S, ''et al.'' |title=Human platelet Ca2+-ATPases: new markers of cell differentiation as illustrated in idiopathic scoliosis. |journal=Platelets |volume=17 |issue= 6 |pages= 421-33 |year= 2006 |pmid= 16973504 |doi= 10.1080/09537100600758719 }}
*{{cite journal | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{ATPases}}
{{WikiDoc Sources}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
 
{{gene-17-stub}}

Latest revision as of 18:24, 29 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is an enzyme that in humans is encoded by the ATP2A3 gene.[1][2]

This gene encodes one of the SERCA Ca2+-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of cells. SERCA3 expression was originally described as non-muscular, but was recently observed in cardiomyocyte. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in 6 transcript variants encoding different isoforms named SERCA3a to SERCA3f.[2]

References

  1. ↑ Dode L, Wuytack F, Kools PF, Baba-Aissa F, Raeymaekers L, Brike F, van de Ven WJ, Casteels R (Nov 1996). "cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca2+-ATPase 3 gene". Biochem J. 318 (2): 689–99. PMC 1217674. PMID 8809064.
  2. ↑ 2.0 2.1 "Entrez Gene: ATP2A3 ATPase, Ca++ transporting, ubiquitous".

External links

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=ATP2A3&oldid=1417947"