WBR0446
| Author | [[PageAuthor::Rim Halaby, M.D. [1] (Reviewed by Alison Leibowitz)]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Pathology |
| Sub Category | SubCategory::Endocrine |
| Prompt | [[Prompt::A 45-year-old female who presents to the physician’s office with complaints of severe diarrhea of several days duration. The patient’s medical history is significant for recurrent kidney stones and parathyroidectomy. Her fasting gastrin level is elevated and endoscopy reveals multiple ulcers in the stomach, duodenum, and jejunum. Which of the following findings is the most likely present in this patient?]] |
| Answer A | AnswerA::Oral ganglioneuroma |
| Answer A Explanation | AnswerAExp::Oral ganglioneuromatosis frequently occurs in patients with MEN2B syndrome. |
| Answer B | AnswerB::Pheochromocytoma |
| Answer B Explanation | AnswerBExp::Pheochromocytoma frequently occurs in MEN 2A and MEN 2B syndromes. |
| Answer C | AnswerC::Medullary thyroid cancer |
| Answer C Explanation | AnswerCExp::Medullary thyroid cancer frequently occurs in MEN 2A and MEN 2B syndromes. |
| Answer D | AnswerD::Prolactinoma |
| Answer D Explanation | AnswerDExp::Prolactinoma, a pituitary tumor, frequently occurs in MEN I syndrome. |
| Answer E | AnswerE::Carcinoid tumor |
| Answer E Explanation | AnswerEExp::Carcinoid tumor is an endocrine tumor, but is not frequently associated with MEN syndrome. |
| Right Answer | RightAnswer::D |
| Explanation | [[Explanation::Men I syndrome is characterized by parathyroid tumors, pituitary tumors, which are usually prolactinoma or GH secreting tumors, and pancreatic endocrine tumors, such as gastrinoma, insulinoma, VIPoma, or glucagonoma. Educational Objective: MEN I syndrome often manifests with pituitary tumors, parathyroid tumors, or pancreatic endocrine tumors. |
| Approved | Approved::Yes |
| Keyword | WBRKeyword::Prolactinoma, WBRKeyword::pheochromocytoma, WBRKeyword::gastrinoma, WBRKeyword::neoplasia, WBRKeyword::MEN I, WBRKeyword::Wermer syndrome, WBRKeyword::diarrhea, WBRKeyword::ulcers |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |