The CHI SQUARE Trial

High Density Lipoprotein Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Objective

To determine the safety and efficacy of CER-001 on atherosclerotic plaque progression and regression in patients with acute coronary syndromes.

Methods

CHI-SQUARE: Can HDL Infusions Significantly Quicken Atherosclerosis Regression? This is a phase II, multi-centered, double-blinded, ascending dose, placebo-controlled, dose-finding trial of CER-001 or placebo in subjects with acute coronary syndromes. 504 patients were grouped into: placebo, low dose, mid dose, and high dose of CER-001 groups to receive a total of 6 infusions in 5 weeks. The total coronary plaque volume is measured with intravascular ultrasound (IVUS).

Results

Pending