Mantle cell lymphoma other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
Overview
Other Diagnostic Studies
FISH
Diagnosis generally requires stained slides of a surgically removed part of a lymph node. Other methods are also commonly used, including cytogenetics and fluorescence in situ hybridization (FISH).
PCR
Polymerase chain reaction (PCR) and CER3 clonotypic primers are additional methods, but are less often used.
Immunophenotype
The immunophenotype profile consists of CD5+ (in about 80%)[1], CD10-/+, CD20+, CD23+/-, CD23-/+ (though plus in rare cases). Generally cyclin D1 is expressed but it may not be required. The workup for Mantle cell lymphoma is similar to the workup for many indolent lymphomas and certain aggressive lymphomas.
Bone Marrow Aspiration
Mantle cell lymphoma is a systemic disease with frequent involvement of the bone marrow and gastrointestinal tract (generally showingpolyposis in the lining). There is also a not-uncommon leukemic phase, marked by presence in the blood. For this reason, both the peripheral blood and bone marrow are evaluated for the presence of malignant cells.
Lumbar Puncture
In some patients with the blastic variant, lumbar puncture is done to evaluate the spinal fluid for involvement.