Zinc finger and BTB domain-containing protein 16

Zinc finger and BTB domain containing 16
File:PBB Protein ZBTB16 image.jpg PDB rendering based on 1buo.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1buo​, 1cs3​
Identifiers
Symbols	ZBTB16 ; PLZF; ZNF145
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21214
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE ZBTB16 205883 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Zinc finger and BTB domain containing 16, also known as ZBTB16, is a human gene.

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized.

See also

• Zbtb7

Further reading

• Chen Z, Brand NJ, Chen A; et al. (1993). "Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia". EMBO J. 12 (3): 1161–7. PMID 8384553.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen SJ, Zelent A, Tong JH; et al. (1993). "Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia". J. Clin. Invest. 91 (5): 2260–7. PMID 8387545.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reid A, Gould A, Brand N; et al. (1996). "Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors". Blood. 86 (12): 4544–52. PMID 8541544.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dong S, Zhu J, Reid A; et al. (1996). "Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein". Proc. Natl. Acad. Sci. U.S.A. 93 (8): 3624–9. PMID 8622986.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Hong SH, David G, Wong CW; et al. (1997). "SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia". Proc. Natl. Acad. Sci. U.S.A. 94 (17): 9028–33. PMID 9256429.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koken MH, Reid A, Quignon F; et al. (1997). "Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies". Proc. Natl. Acad. Sci. U.S.A. 94 (19): 10255–60. PMID 9294197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin RJ, Nagy L, Inoue S; et al. (1998). "Role of the histone deacetylase complex in acute promyelocytic leukaemia". Nature. 391 (6669): 811–4. doi:10.1038/35895. PMID 9486654.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guidez F, Ivins S, Zhu J; et al. (1998). "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia". Blood. 91 (8): 2634–42. PMID 9531570.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• David G, Alland L, Hong SH; et al. (1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID 9627120.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ahmad KF, Engel CK, Privé GG (1998). "Crystal structure of the BTB domain from PLZF". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12123–8. PMID 9770450.CS1 maint: Multiple names: authors list (link)
• van Schothorst EM, Prins DE, Baysal BE; et al. (1999). "Genomic structure of the human PLZF gene". Gene. 236 (1): 21–4. PMID 10433962.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ball HJ, Melnick A, Shaknovich R; et al. (1999). "The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase". Nucleic Acids Res. 27 (20): 4106–13. PMID 10497277.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang T, Xiong H, Kan LX; et al. (1999). "Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11422–7. PMID 10500192.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li X, Peng H, Schultz DC; et al. (1999). "Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein". Cancer Res. 59 (20): 5275–82. PMID 10537309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoatlin ME, Zhi Y, Ball H; et al. (1999). "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood. 94 (11): 3737–47. PMID 10572087.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Melnick AM, Westendorf JJ, Polinger A; et al. (2000). "The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein". Mol. Cell. Biol. 20 (6): 2075–86. PMID 10688654.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hyman J, Chen H, Di Fiore PP; et al. (2000). "Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF)". J. Cell Biol. 149 (3): 537–46. PMID 10791968.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Melnick A, Carlile GW, McConnell MJ; et al. (2001). "AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein". Blood. 96 (12): 3939–47. PMID 11090081.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• He LZ, Bhaumik M, Tribioli C; et al. (2002). "Two critical hits for promyelocytic leukemia". Mol. Cell. 6 (5): 1131–41. PMID 11106752.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• ZBTB16+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.