HSF1

Heat shock transcription factor 1
Identifiers
Symbols	HSF1 ; HSTF1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74556
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Heat shock transcription factor 1, also known as HSF1, is a human gene.

The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene.

See also

• Heat shock factor

Further reading

• Voellmy R (1996). "Sensing stress and responding to stress". EXS. 77: 121–37. PMID 8856972.
• Abravaya K, Myers MP, Murphy SP, Morimoto RI (1992). "The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression". Genes Dev. 6 (7): 1153–64. PMID 1628823.CS1 maint: Multiple names: authors list (link)
• Rabindran SK, Giorgi G, Clos J, Wu C (1991). "Molecular cloning and expression of a human heat shock factor, HSF1". Proc. Natl. Acad. Sci. U.S.A. 88 (16): 6906–10. PMID 1871105.CS1 maint: Multiple names: authors list (link)
• Schuetz TJ, Gallo GJ, Sheldon L; et al. (1991). "Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans". Proc. Natl. Acad. Sci. U.S.A. 88 (16): 6911–5. PMID 1871106.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nunes SL, Calderwood SK (1995). "Heat shock factor-1 and the heat shock cognate 70 protein associate in high molecular weight complexes in the cytoplasm of NIH-3T3 cells". Biochem. Biophys. Res. Commun. 213 (1): 1–6. doi:10.1006/bbrc.1995.2090. PMID 7639722.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Chu B, Soncin F, Price BD; et al. (1997). "Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1". J. Biol. Chem. 271 (48): 30847–57. PMID 8940068.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukunaga R, Hunter T (1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates". EMBO J. 16 (8): 1921–33. doi:10.1093/emboj/16.8.1921. PMID 9155018.
• Nair SC, Toran EJ, Rimerman RA; et al. (1997). "A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor". Cell Stress Chaperones. 1 (4): 237–50. PMID 9222609.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang J, Nueda A, Yoo S, Dynan WS (1997). "Heat shock transcription factor 1 binds selectively in vitro to Ku protein and the catalytic subunit of the DNA-dependent protein kinase". J. Biol. Chem. 272 (41): 26009–16. PMID 9325337.CS1 maint: Multiple names: authors list (link)
• Cotto J, Fox S, Morimoto R (1998). "HSF1 granules: a novel stress-induced nuclear compartment of human cells". J. Cell. Sci. 110 ( Pt 23): 2925–34. PMID 9359875.CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shi Y, Mosser DD, Morimoto RI (1998). "Molecular chaperones as HSF1-specific transcriptional repressors". Genes Dev. 12 (5): 654–66. PMID 9499401.CS1 maint: Multiple names: authors list (link)
• Satyal SH, Chen D, Fox SG; et al. (1998). "Negative regulation of the heat shock transcriptional response by HSBP1". Genes Dev. 12 (13): 1962–74. PMID 9649501.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou X, Tron VA, Li G, Trotter MJ (1998). "Heat shock transcription factor-1 regulates heat shock protein-72 expression in human keratinocytes exposed to ultraviolet B light". J. Invest. Dermatol. 111 (2): 194–8. doi:10.1046/j.1523-1747.1998.00266.x. PMID 9699716.CS1 maint: Multiple names: authors list (link)
• Zou J, Guo Y, Guettouche T; et al. (1998). "Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1". Cell. 94 (4): 471–80. PMID 9727490.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stephanou A, Isenberg DA, Nakajima K, Latchman DS (1999). "Signal transducer and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and Hsp-90beta gene promoters". J. Biol. Chem. 274 (3): 1723–8. PMID 9880553.CS1 maint: Multiple names: authors list (link)
• Dai R, Frejtag W, He B; et al. (2000). "c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity". J. Biol. Chem. 275 (24): 18210–8. doi:10.1074/jbc.M000958200. PMID 10747973.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Choi Y, Asada S, Uesugi M (2000). "Divergent hTAFII31-binding motifs hidden in activation domains". J. Biol. Chem. 275 (21): 15912–6. PMID 10821850.CS1 maint: Multiple names: authors list (link)

External links

• HES1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.